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罗哌卡因的抗肿瘤作用机制及控释体系应用
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Abstract:
恶性肿瘤病死率逐年增高，对人类的生活造成了难以预计的影响。目前针对恶性肿瘤仍以手术切除为主，辅助以放疗、化疗等，但仍存在肿瘤复发及转移等问题。围术期手术操作及麻醉可通过多种因素对肿瘤的预后造成影响，包括改变肿瘤局部微环境变化、提升炎症及应激水平、抑制免疫等促进恶性肿瘤进展，增加术后肿瘤复发及转移风险。近年来研究发现，罗哌卡因(Ropivacaine, RVC)能够通过多种途径影响肿瘤进展，抑制肿瘤活性及转移。文中就罗哌卡因对肿瘤的影响及药物递送体系的应用予以综述，旨在探讨围手术期罗哌卡因及其控释体系在肿瘤中的作用。
The mortality rate of malignant tumors continues to rise annually, posing significant and unpredictable impacts on human life. Currently, the mainstay of treatment for malignant tumors involves surgical resection, coupled with radiotherapy, chemotherapy, and other modalities. Nonetheless, challenges such as tumor recurrence and metastasis persist. Perioperative surgical interventions and anesthesia can influence tumor prognosis through a range of factors, including alterations in the local tumor microenvironment, elevation of inflammatory and stress levels, and suppression of the immune system, all of which can contribute to the progression of malignant tumors and increase the risk of postoperative tumor recurrence and metastasis. Recent research has revealed that ropivacaine (Ropivacaine, RVC) can impact tumor progression through various pathways, inhibiting tumor activity and metastasis. This review aims to provide a comprehensive overview of the effects of ropivacaine on tumors and the application of drug delivery systems, particularly exploring the role of perioperative ropivacaine and its controlled release system in tumor management.
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