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男性与女性在乳腺癌中的对比
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Abstract:
据最新数据表明女性乳腺癌成为全球发病率第二的癌症，严重威胁女性群体的身心健康，并成为其主要死亡原因。但是乳腺癌并不是女性的专属，男性也会患有乳腺癌，由于男性乳腺癌(male breast cancer, MBC)发病率显著低于女性乳腺癌(female breast cancer, FBC)，大多数乳腺癌研究仅包括女性患者，虽然对MBC的生物学、临床表现、遗传学和治疗正在不断发展，但由于这种疾病的罕见性，与FBC相比仍然存在很大的知识差距。MBC与FBC在多个方面相似，例如高雌激素水平和家族癌症史等，所以通常将MBC与FBC相提并论。然而，近年来越来越多的研究表明MBC与FBC之间存在显著差异，应将MBC视为一种与FBC不同的疾病。本文就男性和女性在乳腺癌中不同的流行病学特征、危险因素、肿瘤特征和预后方面的研究进展综述如下。
According to the latest data, female breast cancer has become the second most common cancer in the world, seriously threatening the physical and mental health of the female community and becoming the main cause of death. However, breast cancer is not exclusive to women, and men can also suffer from breast cancer. Because the incidence of male breast cancer (MBC) is significantly lower than that of female breast cancer (FBC), most breast cancers study only includes female patients. Although the biology, clinical manifestations, genetics and treatment of MBC are constantly developing, there is still a large knowledge gap compared with FBC due to the rarity of this disease. MBC and FBC are similar in many aspects, such as high estrogen levels and family cancer history, so MBC is usually compared with FBC. However, more and more studies in recent years have shown that there are significant differences between MBC and FBC, and MBC should be regarded as a different disease from FBC. This article summarizes the research progress of different epidemiological characteristics, risk factors, tumor characteristics and prognosis of men and women in breast cancer as follows.
| [1] | Bray, F., Laversanne, M., Sung, H., Ferlay, J., Siegel, R.L., Soerjomataram, I., et al. (2024) Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 74, 229-263. https://doi.org/10.3322/caac.21834 |
| [2] | Mukherjee, A.G., Gopalakrishnan, A.V., Jayaraj, R., Renu, K., Dey, A., Vellingiri, B., et al. (2023) The Incidence of Male Breast Cancer: From Fiction to Reality—Correspondence. International Journal of Surgery, 109, 2855-2858. https://doi.org/10.1097/js9.0000000000000512 |
| [3] | Anderson, W.F., Jatoi, I., Tse, J. and Rosenberg, P.S. (2010) Male Breast Cancer: A Population-Based Comparison with Female Breast Cancer. Journal of Clinical Oncology, 28, 232-239. https://doi.org/10.1200/jco.2009.23.8162 |
| [4] | Xu, Y., Gong, M., Wang, Y., Yang, Y., Liu, S. and Zeng, Q. (2023) Global Trends and Forecasts of Breast Cancer Incidence and Deaths. Scientific Data, 10, Article No. 334. https://doi.org/10.1038/s41597-023-02253-5 |
| [5] | Leone, J.P., Freedman, R.A., Leone, J., Tolaney, S.M., Vallejo, C.T., Leone, B.A., et al. (2022) Survival in Male Breast Cancer over the Past 3 Decades. JNCI: Journal of the National Cancer Institute, 115, 421-428. https://doi.org/10.1093/jnci/djac241 |
| [6] | Giaquinto, A.N., Sung, H., Miller, K.D., Kramer, J.L., Newman, L.A., Minihan, A., et al. (2022) Breast Cancer Statistics, 2022. CA: A Cancer Journal for Clinicians, 72, 524-541. https://doi.org/10.3322/caac.21754 |
| [7] | Wang, F., Shu, X., Meszoely, I., Pal, T., Mayer, I.A., Yu, Z., et al. (2019) Overall Mortality after Diagnosis of Breast Cancer in Men vs Women. JAMA Oncology, 5, 1589-1596. https://doi.org/10.1001/jamaoncol.2019.2803 |
| [8] | Lei, S., Zheng, R., Zhang, S., Wang, S., Chen, R., Sun, K., et al. (2021) Global Patterns of Breast Cancer Incidence and Mortality: A Population‐Based Cancer Registry Data Analysis from 2000 to 2020. Cancer Communications, 41, 1183-1194. https://doi.org/10.1002/cac2.12207 |
| [9] | Chen, Z., Xu, L., Shi, W., Zeng, F., Zhuo, R., Hao, X., et al. (2020) Trends of Female and Male Breast Cancer Incidence at the Global, Regional, and National Levels, 1990-2017. Breast Cancer Research and Treatment, 180, 481-490. https://doi.org/10.1007/s10549-020-05561-1 |
| [10] | Grabinski, V.F. and Brawley, O.W. (2022) Disparities in Breast Cancer. Obstetrics and Gynecology Clinics of North America, 49, 149-165. https://doi.org/10.1016/j.ogc.2021.11.010 |
| [11] | Ellington, T.D., Henley, S.J., Wilson, R.J. and Miller, J.W. (2020) Breast Cancer Survival among Males by Race, Ethnicity, Age, Geographic Region, and Stage—United States, 2007-2016. MMWR. Morbidity and Mortality Weekly Report, 69, 1481-1484. https://doi.org/10.15585/mmwr.mm6941a2 |
| [12] | Sarmiento, S., McColl, M., Musavi, L., Gani, F., Canner, J.K., Jacobs, L., et al. (2020) Male Breast Cancer: A Closer Look at Patient and Tumor Characteristics and Factors That Affect Survival Using the National Cancer Database. Breast Cancer Research and Treatment, 180, 471-479. https://doi.org/10.1007/s10549-020-05556-y |
| [13] | Li, N., Deng, Y., Zhou, L., Tian, T., Yang, S., Wu, Y., et al. (2019) Global Burden of Breast Cancer and Attributable Risk Factors in 195 Countries and Territories, from 1990 to 2017: Results from the Global Burden of Disease Study 2017. Journal of Hematology & Oncology, 12, Article No. 140. https://doi.org/10.1186/s13045-019-0828-0 |
| [14] | Giordano, S.H. (2018) Breast Cancer in Men. New England Journal of Medicine, 378, 2311-2320. https://doi.org/10.1056/nejmra1707939 |
| [15] | Wang, H., MacInnis, R.J. and Li, S. (2023) Family History and Breast Cancer Risk for Asian Women: A Systematic Review and Meta-Analysis. BMC Medicine, 21, Article No. 239. https://doi.org/10.1186/s12916-023-02950-3 |
| [16] | Brinton, L.A., Richesson, D.A., Gierach, G.L., Lacey, J.V., Park, Y., Hollenbeck, A.R., et al. (2008) Prospective Evaluation of Risk Factors for Male Breast Cancer. JNCI Journal of the National Cancer Institute, 100, 1477-1481. https://doi.org/10.1093/jnci/djn329 |
| [17] | Valentini, V., Bucalo, A., Conti, G., Celli, L., Porzio, V., Capalbo, C., et al. (2024) Gender-Specific Genetic Predisposition to Breast Cancer: BRCA Genes and Beyond. Cancers, 16, Article No. 579. https://doi.org/10.3390/cancers16030579 |
| [18] | Hu, C., Hart, S.N., Gnanaolivu, R., Huang, H., Lee, K.Y., Na, J., et al. (2021) A Population-Based Study of Genes Previously Implicated in Breast Cancer. New England Journal of Medicine, 384, 440-451. https://doi.org/10.1056/nejmoa2005936 |
| [19] | Li, S., Silvestri, V., Leslie, G., Rebbeck, T.R., Neuhausen, S.L., Hopper, J.L., et al. (2022) Cancer Risks Associated with brca1 and brca2 Pathogenic Variants. Journal of Clinical Oncology, 40, 1529-1541. https://doi.org/10.1200/jco.21.02112 |
| [20] | Bucalo, A., Conti, G., Valentini, V., Capalbo, C., Bruselles, A., Tartaglia, M., et al. (2023) Male Breast Cancer Risk Associated with Pathogenic Variants in Genes Other than BRCA1/2: An Italian Case-Control Study. European Journal of Cancer, 188, 183-191. https://doi.org/10.1016/j.ejca.2023.04.022 |
| [21] | Choi, Y., Terry, M.B., Daly, M.B., MacInnis, R.J., Hopper, J.L., Colonna, S., et al. (2021) Association of Risk-Reducing Salpingo-Oophorectomy with Breast Cancer Risk in Women with brca1 and brca2 Pathogenic Variants. JAMA Oncology, 7, 585-592. https://doi.org/10.1001/jamaoncol.2020.7995 |
| [22] | Sun, Y., Zhao, Z., Yang, Z., Xu, F., Lu, H., Zhu, Z., et al. (2017) Risk Factors and Preventions of Breast Cancer. International Journal of Biological Sciences, 13, 1387-1397. https://doi.org/10.7150/ijbs.21635 |
| [23] | Brinton, L.A., Cook, M.B., McCormack, V., Johnson, K.C., Olsson, H., Casagrande, J.T., et al. (2014) Anthropometric and Hormonal Risk Factors for Male Breast Cancer: Male Breast Cancer Pooling Project Results. JNCI Journal of the National Cancer Institute, 106, djt465. https://doi.org/10.1093/jnci/djt465 |
| [24] | Fox, S., Speirs, V. and Shaaban, A.M. (2021) Male Breast Cancer: An Update. Virchows Archiv, 480, 85-93. https://doi.org/10.1007/s00428-021-03190-7 |
| [25] | Swerdlow, A.J., Schoemaker, M.J., Higgins, C.D., Wright, A.F. and Jacobs, P.A. (2005) Cancer Incidence and Mortality in Men with Klinefelter Syndrome: A Cohort Study. JNCI: Journal of the National Cancer Institute, 97, 1204-1210. https://doi.org/10.1093/jnci/dji240 |
| [26] | Zaman, M., de Vale, M.L., Coultas, C., Goff, L., Mernagh-iles, A., L’Esperance, V., et al. (2023) Factors Affecting the Delivery of Community-Based Salon Interventions to Prevent Cardiovascular Disease and Breast Cancer among Ethnically Diverse Women in South London: A Concept-Mapping Approach. The Lancet, 402, S96. https://doi.org/10.1016/s0140-6736(23)02148-7 |
| [27] | Zhu, P., Zhang, Y., Chen, Q., Qiu, W., Chen, M., Xue, L., et al. (2023) The Interaction of Diet, Alcohol, Genetic Predisposition, and the Risk of Breast Cancer: A Cohort Study from the UK Biobank. European Journal of Nutrition, 63, 343-356. https://doi.org/10.1007/s00394-023-03269-8 |
| [28] | Campbell, N.J., Barton, C., Cutress, R.I. and Copson, E.R. (2022) Impact of Obesity, Lifestyle Factors and Health Interventions on Breast Cancer Survivors. Proceedings of the Nutrition Society, 82, 47-57. https://doi.org/10.1017/s0029665122002816 |
| [29] | Swerdlow, A.J., Bruce, C., Cooke, R., Coulson, P., Schoemaker, M.J. and Jones, M.E. (2022) Risk of Breast Cancer in Men in Relation to Weight Change: A National Case‐Control Study in England and Wales. International Journal of Cancer, 150, 1804-1811. https://doi.org/10.1002/ijc.33938 |
| [30] | Pedersen, J.E. and Hansen, J. (2023) Parental Occupational Exposure to Chemicals and Risk of Breast Cancer in Female Offspring. Environmental Research, 227, Article ID: 115817. https://doi.org/10.1016/j.envres.2023.115817 |
| [31] | Florez-Garcia, V., Guevara-Romero, E., Hawkins, M., Bautista, L., Jenson, T., Yu, J., et al. (2023) Cadmium Exposure and Risk of Breast Cancer: A Meta-Analysis. Environmental Research, 219, Article ID: 115109. https://doi.org/10.1016/j.envres.2022.115109 |
| [32] | Amadou, A., Praud, D., Coudon, T., Deygas, F., Grassot, L., Dubuis, M., et al. (2023) Long-Term Exposure to Nitrogen Dioxide Air Pollution and Breast Cancer Risk: A Nested Case-Control within the French E3N Cohort Study. Environmental Pollution, 317, Article ID: 120719. https://doi.org/10.1016/j.envpol.2022.120719 |
| [33] | Gabet, S., Lemarchand, C., Guénel, P. and Slama, R. (2021) Breast Cancer Risk in Association with Atmospheric Pollution Exposure: A Meta-Analysis of Effect Estimates Followed by a Health Impact Assessment. Environmental Health Perspectives, 129, Article No. 57012. https://doi.org/10.1289/ehp8419 |
| [34] | Guo, Q., Lu, Y., Liu, W., Lan, G. and Lan, T. (2024) The Global, Regional, and National Disease Burden of Breast Cancer Attributable to Tobacco from 1990 to 2019: A Global Burden of Disease Study. BMC Public Health, 24, Article No. 107. https://doi.org/10.1186/s12889-023-17405-w |
| [35] | Talibov, M., Hansen, J., Heikkinen, S., Martinsen, J., Sparen, P., Tryggvadottir, L., et al. (2019) Occupational Exposures and Male Breast Cancer: A Nested Case-Control Study in the Nordic Countries. The Breast, 48, 65-72. https://doi.org/10.1016/j.breast.2019.09.004 |
| [36] | Dall, G.V. and Britt, K.L. (2017) Estrogen Effects on the Mammary Gland in Early and Late Life and Breast Cancer Risk. Frontiers in Oncology, 7, Article No. 110. https://doi.org/10.3389/fonc.2017.00110 |
| [37] | Cereser, B., Yiu, A., Tabassum, N., Del Bel Belluz, L., Zagorac, S., Ancheta, K.R.Z., et al. (2023) The Mutational Landscape of the Adult Healthy Parous and Nulliparous Human Breast. Nature Communications, 14, Article No. 5136. https://doi.org/10.1038/s41467-023-40608-z |
| [38] | Nichols, H.B., Schoemaker, M.J., Cai, J., Xu, J., Wright, L.B., Brook, M.N., et al. (2018) Breast Cancer Risk after Recent Childbirth: A Pooled Analysis of 15 Prospective Studies. Annals of Internal Medicine, 170, 222-302. https://doi.org/10.7326/m18-1323 |
| [39] | Lynge, E., Vejborg, I., Lillholm, M., Nielsen, M., Napolitano, G. and von Euler‐Chelpin, M. (2022) Breast Density and Risk of Breast Cancer. International Journal of Cancer, 152, 1150-1158. https://doi.org/10.1002/ijc.34316 |
| [40] | Hartmann, L.C., Sellers, T.A., Frost, M.H., Lingle, W.L., Degnim, A.C., Ghosh, K., et al. (2005) Benign Breast Disease and the Risk of Breast Cancer. New England Journal of Medicine, 353, 229-237. https://doi.org/10.1056/nejmoa044383 |
| [41] | Coopey, S.B., Kartal, K., Li, C., Yala, A., Barzilay, R., Faulkner, H.R., et al. (2019) Atypical Ductal Hyperplasia in Men with Gynecomastia: What Is Their Breast Cancer Risk? Breast Cancer Research and Treatment, 175, 1-4. https://doi.org/10.1007/s10549-018-05117-4 |
| [42] | Yao, N., Shi, W., Liu, T., Siyin, S.T., Wang, W., Duan, N., et al. (2022) Clinicopathologic Characteristics and Prognosis for Male Breast Cancer Compared to Female Breast Cancer. Scientific Reports, 12, Article No. 220. https://doi.org/10.1038/s41598-021-04342-0 |
| [43] | ？nder, ？., Azizova, A., Durhan, G., Elibol, F.D., Akp？nar, M.G. and Demirkaz？k, F. (2020) Imaging Findings and Classification of the Common and Uncommon Male Breast Diseases. Insights into Imaging, 11, Article No. 27. https://doi.org/10.1186/s13244-019-0834-3 |
| [44] | Shaaban, A.M. (2019) Pathology of the Male Breast. Diagnostic Histopathology, 25, 138-142. https://doi.org/10.1016/j.mpdhp.2019.01.004 |
| [45] | Tan, P.H., Ellis, I., Allison, K., Brogi, E., Fox, S.B., Lakhani, S., et al. (2020) The 2019 World Health Organization Classification of Tumours of the Breast. Histopathology, 77, 181-185. https://doi.org/10.1111/his.14091 |
| [46] | Accomasso, F., Actis, S., Minella, C., Rosso, R., Granaglia, C., Ponzone, R., et al. (2023) Clinical, Pathological, and Prognostic Features of Male Breast Cancer: A Multicenter Study. Current Oncology, 30, 9860-9871. https://doi.org/10.3390/curroncol30110716 |
| [47] | Xie, J., Ying, Y., Xu, B., Li, Y., Zhang, X. and Li, C. (2019) Metastasis Pattern and Prognosis of Male Breast Cancer Patients in US: A Population-Based Study from SEER Database. Therapeutic Advances in Medical Oncology, 11, 1-12. https://doi.org/10.1177/1758835919889003 |
| [48] | Niccolai, E., Baldi, S., Nannini, G., Gensini, F., Papi, L., Vezzosi, V., et al. (2023) Breast Cancer: The First Comparative Evaluation of Oncobiome Composition between Males and Females. Biology of Sex Differences, 14, Article No. 37. https://doi.org/10.1186/s13293-023-00523-w |
| [49] | Sineshaw, H.M., Freedman, R.A., Ward, E.M., Flanders, W.D. and Jemal, A. (2015) Black/white Disparities in Receipt of Treatment and Survival among Men with Early-Stage Breast Cancer. Journal of Clinical Oncology, 33, 2337-2344. https://doi.org/10.1200/jco.2014.60.5584 |
| [50] | Miao, H., Verkooijen, H.M., Chia, K., Bouchardy, C., Pukkala, E., Lar？nningen, S., et al. (2011) Incidence and Outcome of Male Breast Cancer: An International Population-Based Study. Journal of Clinical Oncology, 29, 4381-4386. https://doi.org/10.1200/jco.2011.36.8902 |
| [51] | Konduri, S., Singh, M., Bobustuc, G., Rovin, R. and Kassam, A. (2020) Epidemiology of Male Breast Cancer. The Breast, 54, 8-14. https://doi.org/10.1016/j.breast.2020.08.010 |
| [52] | Fang, W., Huang, Y., Han, X., Peng, J. and Zheng, M. (2021) Characteristics of Metastasis and Survival between Male and Female Breast Cancer with Different Molecular Subtypes: A Population‐based Observational Study. Cancer Medicine, 11, 764-777. https://doi.org/10.1002/cam4.4469 |
| [53] | Grenader, T., Goldberg, A. and Shavit, L. (2008) Second Cancers in Patients with Male Breast Cancer: A Literature Review. Journal of Cancer Survivorship: Research and Practice, 2, 73-78. https://doi.org/10.1007/s11764-008-0042-5 |
| [54] | Kim, H., Yoon, T.I., Kim, S., Lee, S.B., Kim, J., Chung, I.Y., et al. (2023) Age-Related Incidence and Peak Occurrence of Contralateral Breast Cancer. JAMA Network Open, 6, e2347511. https://doi.org/10.1001/jamanetworkopen.2023.47511 |
| [55] | Allen, I., Hassan, H., Sofianopoulou, E., Eccles, D., Turnbull, C., Tischkowitz, M., et al. (2022) Risk of Developing a Second Primary Cancer in Male Breast Cancer Survivors: A Systematic Review and Meta-Analysis. British Journal of Cancer, 127, 1660-1669. https://doi.org/10.1038/s41416-022-01940-1 |
| [56] | Ramin, C., Veiga, L.H.S., Vo, J.B., Curtis, R.E., Bodelon, C., Aiello Bowles, E.J., et al. (2023) Risk of Second Primary Cancer among Women in the Kaiser Permanente Breast Cancer Survivors Cohort. Breast Cancer Research, 25, Article No. 50. https://doi.org/10.1186/s13058-023-01647-y |
