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早发型和晚发型精神分裂症的比较研究进展
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Abstract:
精神分裂症(Schizophrenia, SZ)是最具破坏性的精神疾病之一。从临床实践和研究角度出发，将精神分裂症分为早发型和晚发型两大类别，前者在18岁之前发病，后者在40至60岁之间出现精神分裂症症状。通过系统的文献复习，本文较全面地比较了此两类精神分裂症，包括它们的临床特征、治疗原则和预后，重点比较了它们在发病机制方面的异同。我们期望该文帮助读者深入理解精神分裂症在不同人群的表现和病程，为精神科医生针对性地制定治疗方案提供参考。
Schizophrenia (SZ) is one of the most devastating mental disorders. From the perspective of clinical practice and research, schizophrenia is categorized into the early-onset and late-onset phenotypes. The former has its first onset before the age of 18, while the latter presents the first-episode between the ages of 40 and 60. This article, following a systematic literature review, compared the two phenotypes of schizophrenia in multiple aspects, including clinical characteristics, treatment principles, prognosis, and pathogenesis in more details. It is expected to help readers deeply understand the clinical manifestations and trajectory of the two phenotypes of schizophrenia, and provide better reference for clinical psychiatrists to formulate targeted treatment plans.
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