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胆红素与特发性膜性肾病的研究进展
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Abstract:
胆红素是血红蛋白的代谢产物，既往被认为是一种有害物质，高浓度的胆红素具有细胞毒性，近年来有研究表明，胆红素在生理浓度下可有效清除氧自由基，减少氧自由基对血管内皮细胞和平滑肌细胞的损害，减少低密度脂蛋白的氧化修饰，是抗氧化剂和细胞保护剂，同时还具备有抗炎、调节脂质代谢、抑制血管平滑肌增殖、抗血小板聚集等功能。在许多的疾病发生发展中起着重要作用，本文将胆红素与膜性肾病研究进展予以综述。
Bilirubin is a metabolite of hemoglobin, which has been regarded as a harmful substance, high concentration of bilirubin has cytotoxicity. In recent years, it has been shown that bilirubin can effectively scavenge oxygen radicals at physiological concentration, reduce the damage of oxygen radicals to vascular endothelial cells and smooth muscle cells, reduce the oxidative modification of low density lipoprotein, is an antioxidant and cellular protective agent, and also has anti-inflammatory, It is an antioxidant and cytoprotective agent, and also has the functions of anti-inflammatory, regulating lipid metabolism, inhibiting the proliferation of vascular smooth muscle, and anti-platelet aggregation. Bilirubin plays an important role in the development of many diseases. In this paper, the research progress of bilirubin and membranous nephropathy is summarized.
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