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m6A甲基转移酶ZC3H13在肿瘤中的研究进展
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Abstract:
N6-甲基腺苷(m6A) RNA修饰在肿瘤的发生发展中起着非常重要的作用。m6A的写入器、擦除器和读取器在m6A修饰中发挥重要的生物学作用。越来越多的研究证实m6A基因的异常跟癌症的发生发展密切相关。ZC3H13在多种系统肿瘤中异常表达，且与肿瘤的恶性程度密切相关。本研究就m6A甲基转移酶ZC3H13在各系统肿瘤中的研究进展进行综述。
RNA modification of N6-methyladenosine (m6A) plays a very important role in the occurrence and development of tumors. The writer, eraser and reader of m6A play an important biological role in M6A modification. More and more studies have confirmed that the abnormality of m6A gene is closely related to the occurrence and development of cancer. ZC3H13 is abnormally expressed in a variety of systemic tumors, and is closely related to the malignant degree of tumors. In this study, the research progress of m6A methyltransferase ZC3H13 in tumors of various systems was reviewed.
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