全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

代谢综合征与绝经后乳腺癌患者及相关因素研究
Metabolic Syndrome and Postmenopausal Breast Cancer Patients and Related Factors Study

DOI: 10.12677/acm.2024.1472023, PP. 365-371

Keywords: 代谢综合征,绝经后乳腺癌患者,胰岛素
Metabolic Syndrome
, Postmenopausal Breast Cancer Patients, Insulin

Full-Text   Cite this paper   Add to My Lib

Abstract:

代谢综合征是一种常见的代谢性疾病,包括肥胖、高血压、高血糖和高胆固醇。与绝经后乳腺癌患者之间存在一定的关联。越来越多的证据表明代谢综合征与绝经后乳腺癌风险增加之间存在关联。其影响机制可能涉及胰岛素、胰岛素样生长因子-1、高胰岛素血症、雌激素、脂肪因子、炎症因子等多种因子。本文就代谢综合征与绝经后乳腺癌患者的相关性研究进展做一概述,为绝经后乳腺癌的预防、治疗提供新思路。
Metabolic syndrome is a common metabolic disorder that includes obesity, high blood pressure, high blood sugar, and high cholesterol. There is an association with postmenopausal breast cancer patients. There is growing evidence of an association between metabolic syndrome and an increased risk of breast cancer after menopause. The influencing mechanism may involve a variety of factors such as insulin, insulin-like growth factor-1, hyperinsulinemia, estrogen, adiptenoid, and inflammatory factors. This article summarizes the research progress on the correlation between metabolic syndrome and postmenopausal breast cancer, and provides new ideas for the prevention and treatment of postmenopausal breast cancer.

References

[1]  Son, D.H., Ha, H.S., Park, H.M., et al. (2022) New Markers in Metabolic Syndrome. Advances in Clinical Chemistry, 110, 37-71.
[2]  Buono, G., Crispo, A., Giuliano, M., De Angelis, C., Schettini, F., Forestieri, V., et al. (2020) Metabolic Syndrome and Early Stage Breast Cancer Outcome: Results from a Prospective Observational Study. Breast Cancer Research and Treatment, 182, 401-409.
https://doi.org/10.1007/s10549-020-05701-7
[3]  Maiti, B., Kundranda, M.N., Spiro, T.P. and Daw, H.A. (2009) The Association of Metabolic Syndrome with Triple-Negative Breast Cancer. Breast Cancer Research and Treatment, 121, 479-483.
https://doi.org/10.1007/s10549-009-0591-y
[4]  Kabat, G.C., Kim, M., Chlebowski, R.T., Khandekar, J., Ko, M.G., McTiernan, A., et al. (2009) A Longitudinal Study of the Metabolic Syndrome and Risk of Postmenopausal Breast Cancer. Cancer Epidemiology, Biomarkers & Prevention, 18, 2046-2053.
https://doi.org/10.1158/1055-9965.epi-09-0235
[5]  Uzunlulu, M., Telci Caklili, O. and Oguz, A. (2016) Association between Metabolic Syndrome and Cancer. Annals of Nutrition and Metabolism, 68, 173-179.
https://doi.org/10.1159/000443743
[6]  Gershuni, V.M., Ahima, R.S. and Tchou, J. (2016) Obesity and Breast Cancer: A Complex Relationship. Current Surgery Reports, 4, Article No. 14.
https://doi.org/10.1007/s40137-016-0134-5
[7]  Motoki, A.H., Buttros, D.A.B., Gaspar, A.L., Almeida-Filho, B.S., Carvalho-Pessoa, E., Vespoli, H.D.L., et al. (2022) Association between Metabolic Syndrome and Immunohistochemical Profile at Breast Cancer Diagnosis in Postmenopausal Women. Clinical Breast Cancer, 22, e253-e261.
https://doi.org/10.1016/j.clbc.2021.07.009
[8]  Buttros Dde, A., Nahas, E.A., Vespoli Hde, L., Uemura, G., de Almeida Bda, R. and Nahas-Neto, J. (2013) Risk of Metabolic Syndrome in Postmenopausal Breast Cancer Survivors. Menopause, 20, 448-454.
https://doi.org/10.1097/gme.0b013e318272bd4a
[9]  Carr, M.C. (2003) The Emergence of the Metabolic Syndrome with Menopause. The Journal of Clinical Endocrinology & Metabolism, 88, 2404-2411.
https://doi.org/10.1210/jc.2003-030242
[10]  Park, Y., Zhu, S., Palaniappan, L., Heshka, S., Carnethon, M.R. and Heymsfield, S.B. (2003) The Metabolic Syndrome: Prevalence and Associated Risk Factor Findings in the US Population from the Third National Health and Nutrition Examination Survey, 1988-1994. Archives of Internal Medicine, 163, 427-436.
https://doi.org/10.1001/archinte.163.4.427
[11]  Lobo, R.A. (2008) Metabolic Syndrome after Menopause and the Role of Hormones. Maturitas, 60, 10-18.
https://doi.org/10.1016/j.maturitas.2008.02.008
[12]  Healy, L.A., Ryan, A.M., Carroll, P., Ennis, D., Crowley, V., Boyle, T., et al. (2010) Metabolic Syndrome, Central Obesity and Insulin Resistance Are Associated with Adverse Pathological Features in Postmenopausal Breast Cancer. Clinical Oncology, 22, 281-288.
https://doi.org/10.1016/j.clon.2010.02.001
[13]  Xue, F. and Michels, K.B. (2007) Diabetes, Metabolic Syndrome, and Breast Cancer: A Review of the Current Evidence. The American Journal of Clinical Nutrition, 86, 823S-835S.
https://doi.org/10.1093/ajcn/86.3.823s
[14]  Vona-Davis, L., Howard-McNatt, M. and Rose, D.P. (2007) Adiposity, Type 2 Diabetes and the Metabolic Syndrome in Breast Cancer. Obesity Reviews, 8, 395-408.
https://doi.org/10.1111/j.1467-789x.2007.00396.x
[15]  Hallajzadeh, J., Khoramdad, M., Izadi, N., Karamzad, N., Almasi-Hashiani, A., Ayubi, E., et al. (2018) Metabolic Syndrome and Its Components in Premenopausal and Postmenopausal Women: A Comprehensive Systematic Review and Meta-Analysis on Observational Studies. Menopause, 25, 1155-1164.
https://doi.org/10.1097/gme.0000000000001136
[16]  Cao, Z., Zheng, X., Yang, H., Li, S., Xu, F., Yang, X., et al. (2020) Association of Obesity Status and Metabolic Syndrome with Site-Specific Cancers: A Population-Based Cohort Study. British Journal of Cancer, 123, 1336-1344.
https://doi.org/10.1038/s41416-020-1012-6
[17]  Zhao, P., Xia, N., Zhang, H. and Deng, T. (2020) The Metabolic Syndrome Is a Risk Factor for Breast Cancer: A Systematic Review and Meta-Analysis. Obesity Facts, 13, 384-396.
https://doi.org/10.1159/000507554
[18]  Mendon?a, F.M., de Sousa, F.R., Barbosa, A.L., Martins, S.C., Araújo, R.L., Soares, R., et al. (2015) Metabolic Syndrome and Risk of Cancer: Which Link? Metabolism, 64, 182-189.
https://doi.org/10.1016/j.metabol.2014.10.008
[19]  Fernandes, J.V., Cobucci, R.N.O., Jatobá, C.A.N., de Medeiros Fernandes, T.A.A., de Azevedo, J.W.V. and de Araújo, J.M.G. (2015) The Role of the Mediators of Inflammation in Cancer Development. Pathology & Oncology Research, 21, 527-534.
https://doi.org/10.1007/s12253-015-9913-z
[20]  Crespi, E., Bottai, G. and Santarpia, L. (2016) Role of Inflammation in Obesity-Related Breast Cancer. Current Opinion in Pharmacology, 31, 114-122.
https://doi.org/10.1016/j.coph.2016.11.004
[21]  Guo, M., Liu, T., Li, P., Wang, T., Zeng, C., Yang, M., et al. (2019) Association between Metabolic Syndrome and Breast Cancer Risk: An Updated Meta-Analysis of Follow-Up Studies. Frontiers in Oncology, 9, Article 1290.
https://doi.org/10.3389/fonc.2019.01290
[22]  Goldberg, J.E. and Schwertfeger, K.L. (2010) Proinflammatory Cytokines in Breast Cancer: Mechanisms of Action and Potential Targets for Therapeutics. Current Drug Targets, 11, 1133-1146.
https://doi.org/10.2174/138945010792006799
[23]  Cullen, K.J., Yee, D., Sly, W.S., et al. (1990) Insulin-Like Growth Factor Receptor Expression and Function in Human Breast Cancer. Cancer Research, 50, 48-53.
[24]  Belfiore, A., Frittitta, L., Costantino, A., Frasca, F., Pandini, G., Sciacca, L., et al. (1996) Insulin Receptors in Breast Cancer. Annals of the New York Academy of Sciences, 784, 173-188.
https://doi.org/10.1111/j.1749-6632.1996.tb16235.x
[25]  Papa, V., Pezzino, V., Costantino, A., Belfiore, A., Giuffrida, D., Frittitta, L., et al. (1990) Elevated Insulin Receptor Content in Human Breast Cancer. Journal of Clinical Investigation, 86, 1503-1510.
https://doi.org/10.1172/jci114868
[26]  Mathieu, M.C., Clark, G.M., Allred, D.C., et al. (1997) Insulin Receptor Expression and Clinical Outcome in Node-Negative Breast Cancer. Proceedings of the Association of American Physicians, 109, 565-571.
[27]  Hauner, D. and Hauner, H. (2014) Metabolic Syndrome and Breast Cancer: Is There a Link? Breast Care, 9, 277-281.
https://doi.org/10.1159/000365951
[28]  Mauro, L., Naimo, G.D., Ricchio, E., Panno, M.L. and Andò, S. (2015) Cross-talk between Adiponectin and IGF-IR in Breast Cancer. Frontiers in Oncology, 5, Article 157.
https://doi.org/10.3389/fonc.2015.00157
[29]  Xia, B., Hou, L., Kang, H., Chang, W., Liu, Y., Zhang, Y., et al. (2020) NR2F2 Plays a Major Role in Insulin-Induced Epithelial-Mesenchymal Transition in Breast Cancer Cells. BMC Cancer, 20, Article No. 626.
https://doi.org/10.1186/s12885-020-07107-6
[30]  Wairagu, P.M., Phan, A.N., Kim, M., Han, J., Kim, H., Choi, J., et al. (2015) Insulin Priming Effect on Estradiol-Induced Breast Cancer Metabolism and Growth. Cancer Biology & Therapy, 16, 484-492.
https://doi.org/10.1080/15384047.2015.1016660
[31]  Vara, J.á.F., Casado, E., de Castro, J., Cejas, P., Belda-Iniesta, C. and González-Barón, M. (2004) PI3K/Akt Signalling Pathway and Cancer. Cancer Treatment Reviews, 30, 193-204.
https://doi.org/10.1016/j.ctrv.2003.07.007
[32]  Bastarrachea, R.A., López-Alvarenga, J.C., Bolado-García, V.E., et al. (2007) [Macrophages, Inflammation, Adipose Tissue, Obesity and Insulin Resistance]. Gaceta Medica de Mexico, 143, 505-512.
[33]  Buono, G., Crispo, A., Giuliano, M., De Angelis, C., Schettini, F., Forestieri, V., et al. (2020) Metabolic Syndrome and Early Stage Breast Cancer Outcome: Results from a Prospective Observational Study. Breast Cancer Research and Treatment, 182, 401-409.
https://doi.org/10.1007/s10549-020-05701-7
[34]  Hagemann, T., Wilson, J., Kulbe, H., Li, N.F., Leinster, D.A., Charles, K., et al. (2005) Macrophages Induce Invasiveness of Epithelial Cancer Cells via NF-κB and JNK. The Journal of Immunology, 175, 1197-1205.
https://doi.org/10.4049/jimmunol.175.2.1197
[35]  Tomita, Y., Yang, X., Ishida, Y., Nemoto-Sasaki, Y., Kondo, T., Oda, M., et al. (2004) Spontaneous Regression of Lung Metastasis in the Absence of Tumor Necrosis Factor Receptor P55. International Journal of Cancer, 112, 927-933.
https://doi.org/10.1002/ijc.20493
[36]  Balkwill, F. (2009) Tumour Necrosis Factor and Cancer. Nature Reviews Cancer, 9, 361-371.
https://doi.org/10.1038/nrc2628
[37]  Lu, H., Ouyang, W. and Huang, C. (2006) Inflammation, a Key Event in Cancer Development. Molecular Cancer Research, 4, 221-233.
https://doi.org/10.1158/1541-7786.mcr-05-0261
[38]  van Kruijsdijk, R.C.M., van der Wall, E. and Visseren, F.L.J. (2009) Obesity and Cancer: The Role of Dysfunctional Adipose Tissue. Cancer Epidemiology, Biomarkers & Prevention, 18, 2569-2578.
https://doi.org/10.1158/1055-9965.epi-09-0372
[39]  Trinchieri, G. (2012) Cancer and Inflammation: An Old Intuition with Rapidly Evolving New Concepts. Annual Review of Immunology, 30, 677-706.
https://doi.org/10.1146/annurev-immunol-020711-075008
[40]  Uzunlulu, M., Telci Caklili, O. and Oguz, A. (2016) Association between Metabolic Syndrome and Cancer. Annals of Nutrition and Metabolism, 68, 173-179.
https://doi.org/10.1159/000443743
[41]  Zorena, K., Jachimowicz-Duda, O., ?l?zak, D., Robakowska, M. and Mrugacz, M. (2020) Adipokines and Obesity. Potential Link to Metabolic Disorders and Chronic Complications. International Journal of Molecular Sciences, 21, Article 3570.
https://doi.org/10.3390/ijms21103570
[42]  Forte, V., Pandey, A., Abdelmessih, R., Forte, G., Whaley-Connell, A., Sowers, J.R., et al. (2012) Obesity, Diabetes, the Cardiorenal Syndrome, and Risk for Cancer. Cardiorenal Medicine, 2, 143-162.
https://doi.org/10.1159/000337314
[43]  Shen, W., Punyanitya, M., Silva, A.M., Chen, J., Gallagher, D., Sardinha, L.B., et al. (2009) Sexual Dimorphism of Adipose Tissue Distribution across the Lifespan: A Cross-Sectional Whole-Body Magnetic Resonance Imaging Study. Nutrition & Metabolism, 6, Article No. 17.
https://doi.org/10.1186/1743-7075-6-17
[44]  La Vecchia, C., Negri, E., Franceschi, S., Talamini, R., Bruzzi, P., Palli, D., et al. (1997) Body Mass Index and Post-Menopausal Breast Cancer: An Age-Specific Analysis. British Journal of Cancer, 75, 441-444.
https://doi.org/10.1038/bjc.1997.73
[45]  Key, T.J., Appleby, P.N., Reeves, G.K., et al. (2003) Body Mass Index, Serum Sex Hormones, and Breast Cancer Risk in Postmenopausal Women. JNCI Journal of the National Cancer Institute, 95, 1218-1226.
https://doi.org/10.1093/jnci/djg022
[46]  Lorincz, A.M. and Sukumar, S. (2006) Molecular Links between Obesity and Breast Cancer. Endocrine-Related Cancer, 13, 279-292.
https://doi.org/10.1677/erc.1.00729
[47]  Dibaba, D.T., Ogunsina, K., Braithwaite, D. and Akinyemiju, T. (2018) Metabolic Syndrome and Risk of Breast Cancer Mortality by Menopause, Obesity, and Subtype. Breast Cancer Research and Treatment, 174, 209-218.
https://doi.org/10.1007/s10549-018-5056-8
[48]  Lawlor, D.A., Smith, G.D. and Ebrahim, S. (2004) Hyperinsulinaemia and Increased Risk of Breast Cancer: Findings from the British Women’s Heart and Health Study. Cancer Causes & Control, 15, 267-275.
https://doi.org/10.1023/b:caco.0000024225.14618.a8
[49]  Berrino, F., Villarini, A., Traina, A., Bonanni, B., Panico, S., Mano, M.P., et al. (2014) Metabolic Syndrome and Breast Cancer Prognosis. Breast Cancer Research and Treatment, 147, 159-165.
https://doi.org/10.1007/s10549-014-3076-6
[50]  Giacosa, A., Barale, R., Bavaresco, L., Gatenby, P., Gerbi, V., Janssens, J., et al. (2013) Cancer Prevention in Europe: The Mediterranean Diet as a Protective Choice. European Journal of Cancer Prevention, 22, 90-95.
https://doi.org/10.1097/cej.0b013e328354d2d7
[51]  Wang, M., Cheng, N., Zheng, S., Wang, D., Hu, X., Ren, X., et al. (2015) Metabolic Syndrome and the Risk of Breast Cancer among Postmenopausal Women in North-West China. Climacteric, 18, 852-858.
https://doi.org/10.3109/13697137.2015.1071346

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133