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卟啉代谢在脂肪性肝病方面的研究进展
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Abstract:
近年来由于人口老龄化、病毒性肝炎控制的改善以及肥胖和酒精中毒的流行，脂肪肝(FLD)正在成为中国慢性肝病的主要原因。脂肪性肝病分为酒精性肝病和非酒精性脂肪性肝病，二者虽然发病机制不同，但最终都会引起线粒体功能障碍，进一步导致肝损伤。卟啉是生物体合成叶绿素、血红素、维生素B12等必不可少的前体物质，其合成代谢的重要步骤发生在肝细胞线粒体中，脂肪性肝病导致的线粒体障碍会进一步引起卟啉合成代谢紊乱，因此我们认为血卟啉检测可以作为肝脏损害检测的指标之一，并为脂肪肝治疗提供有效靶点。
Fatty liver disease (FLD) is becoming a major cause of chronic liver disease in China in recent years due to an aging population, improved control of viral hepatitis, and the prevalence of obesity and alcoholism. Fatty liver disease is divided into alcoholic liver disease and non-alcoholic fatty liver disease. Although the pathogenesis of both is different, they will eventually cause mitochondrial dysfunction and further lead to liver injury. Porphyrin is an essential precursor for the synthesis of chlorophyll, heme, vitamin B12, etc., and an important step of its anabolism occurs in mitochondria of liver cells. Mitochondrial disorders caused by fatty liver disease will further cause porphyrin anabolism disorders. Therefore, we believe that the detection of blood porphyrin can be used as one of the indicators for the detection of liver damage. And provide an effective target for the treatment of fatty liver.
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