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细胞死亡在肿瘤中的研究进展
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Abstract:
细胞死亡机制在肿瘤的发生、发展和治疗中扮演着关键角色。本文综述了细胞死亡的不同类型及其在肿瘤发病中的机制，特别关注了坏死性凋亡，细胞焦亡、铁死亡、铜死亡和双硫死亡的关键调控机制。并尝试对如何针对这些细胞死亡方式进行治疗开发做出讨论以期为癌症患者开发基于细胞死亡的新药提供思路。
Cell death mechanisms play crucial roles in the occurrence, development, and treatment of tumors. This article reviews different types of cell death and their mechanisms in tumorigenesis, with a particular focus on necroptosis, ferroptosis, pyroptosis, and apoptosis, highlighting key regulatory mechanisms. It also attempts to discuss how to develop treatments targeting these cell death pathways, aiming to provide insights for the development of new drugs based on cell death for cancer patients.
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