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妊娠期生殖道微生物分布特征与妊娠结局的研究现状
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Abstract:
女性生殖道菌群与宿主构成了相互制约、相互协调的微生态平衡，乳酸杆菌是女性生殖道中最重要的微生物，产生的代谢产物可以构成防止外来细菌入侵的一道生物屏障，防止炎症感染，还可以最大限度地提高女性成功妊娠率。当菌群环境失调时，则会导致各种感染，如细菌性阴道病、滴虫性阴道炎、衣原体感染等，对妊娠结局产生不良影响，如胎膜早破、早产、流产、绒毛膜羊膜炎等。本文就女性生殖道微生物在正常妊娠中的影响及常见生殖道微生物与妊娠不良结局之间的相关性进行论述，为研究不良妊娠结局发生的作用机制及治疗提供理论依据。
The female reproductive tract microflora and the host constitute a mutually restricted and coordinated microecological balance. Lactobacillus is the most important microbe in the female reproductive tract. The metabolites produced can constitute a biological barrier to prevent the invasion of foreign bacteria, prevent inflammation and infection, and also maximize the successful pregnancy rate of women. When the bacterial environment is unbalanced, it will lead to various infections, such as bacterial vaginosis, trichomoniasis vaginitis, chlamydia infection, etc., which will have adverse effects on pregnancy outcomes, such as premature rupture of membranes, premature delivery, abortion, chorionic amniotic inflammation, etc. This paper discusses the influence of female reproductive tract microbes on normal pregnancy and the correlation between common reproductive tract microbes and adverse pregnancy outcomes, providing theoretical basis for studying the mechanism of adverse pregnancy outcomes and treatment.
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