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胆囊切除术后与NAFLD关系研究进展
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Abstract:
越来越多的证据表明，胆囊切除术后是非酒精性脂肪性肝病(non-alcoholic fatty liver disease, NAFLD)的独立危险因素。然而，胆囊切除术后与NAFLD之间的关系及潜在机制尚不清楚。胆囊切除术改变了进入肠道的胆汁流量和胆汁酸(bile acid, BA)的肠肝循环，这可能改变了胆汁酸和肠道微生物之间的相互作用，法尼醇X受体(Farnesoid X receptor, FXR)作为胆汁酸代谢和肠肝循环的关键调节因子，可在肠道和肝脏之间提供对话。本综述的目的是整合有关FXR、肠道微生物群、胆汁酸在胆囊切除术后NAFLD的相关文献进展进行概述。
There is increasing evidence that post-cholecystectomy is an independent risk factor for non-alcoholic fatty liver disease (NAFLD). However, the relationship between post-cholecystectomy and NAFLD and the underlying mechanisms are unclear. Cholecystectomy alters the flow of bile into the gut and enterohepatic circulation of bile acid (BA), which may alter the interaction between bile acids and gut microorganisms, and farnesol X receptor (FXR), a key regulator of bile acid metabolism and enterohepatic circulation, may provide a dialog between the gut and the liver. The purpose of this review is to integrate an overview of relevant literature advances regarding FXR, gut microbiota, and bile acids in post-cholecystectomy NAFLD.
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