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2型糖尿病合并高尿酸血症患者血压变异性的研究进展
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Abstract:
2型糖尿病(type 2 diabetes mellitus, T2DM)又称为非胰岛素依赖性糖尿病，指体内胰岛素分泌相对不足，易发生血管病变，特别是微血管病变，在神经、视网膜、肾、皮肤、肌肉以及心脏等器官中出现微血管基底膜增厚或肥大，严重威胁人们的生命健康。高尿酸血症(hyperuricemia, HUA)是体温37℃时，血清中单钠尿酸盐(MSU)的饱和溶解度为404.5 μmol/L (6.8 mg/dl)，通常定义当血清尿酸水平 > 420 μmol/L (约7 mg/dl)。血压变异性(blood pressure variability, BPV)是定量评价心血管自主神经活动的无创指标，主要反映交感和迷走神经对心血管的动态调节过程。既往研究表明BPV作为独立于血压水平的危险因素，与全因死亡率、心血管疾病死亡率、冠状动脉硬化性心脏病和卒中风险相关。有研究表明，2型糖尿病与血压变异性关系密切，为此，本文总结相关文献内容，综述2型糖尿病合并高尿酸血症患者血压变异性的研究进展，为今后的研究提供参考。
Type 2 diabetes mellitus (T2DM), also known as non insulin dependent diabetes, refers to the relatively insufficient insulin secretion in the body, which is prone to vascular diseases, especially microvascular diseases. The thickening or hypertrophy of microvascular basement membrane in nerve, retina, kidney, skin, muscle, heart and other organs is a serious threat to people’s life and health. Hyperuricemia (HUA) is a condition where the saturation solubility of monosodium urate (MSU) in serum is 404.5 μmol/L (6.8 mg/dl) at a body temperature of 37？C, usually defined as serum uric acid level > 420 μmol/L (approximately 7 mg/dl). Blood pressure variability (BPV) is a non-invasive indicator for quantitatively evaluating cardiovascular autonomic activity, mainly reflecting the dynamic regulatory process of sympathetic and vagus nerves on cardiovascular system. Previous studies have shown that BPV, as an independent risk factor of blood pressure levels, is associated with all-cause mortality, cardiovascular disease mortality, coronary artery atherosclerotic heart disease, and stroke risk. Some studies have shown that type 2 diabetes is closely related to blood pressure variability. Therefore, this article summarizes the relevant literature, reviews the research progress of blood pressure variability in type 2 diabetes patients with hyperuricemia, and provides reference for future research.
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