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虾青素在中毒性肝损伤中作用的研究进展
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Abstract:
中毒性肝损伤指各种药物、毒物及其代谢产物引起的肝脏损伤性病变。其病因繁多，机制复杂、病情进展迅速，病死率高，越来越受到人们的关注，寻找能够有效治疗肝脏疾病的解毒药物显得尤为重要。虾青素是一种脂溶性类胡萝卜素，广泛分布在海洋藻类、菌类和甲壳类动物中，研究表明，虾青素在抗氧化、抗炎、免疫调节、抑制细胞凋亡、抑制肝纤维化等方面对肝损伤具有显著作用，本文就虾青素在中毒性肝损伤的研究现状展开综述，以期为虾青素的进一步研究及中毒性肝损伤的新药研发提供新的思路。
Toxic liver injury refers to liver injury caused by various drugs, poisons and their metabolites. With various etiology, complex mechanism, rapid progression and high fatality rate, it has attracted more and more attention. It is particularly important to find detoxification drugs that can effectively treat liver diseases. Astaxanthin is a kind of lipid soluble carotenoid, widely distributed in Marine algae, fungi and crustaceans. Studies have shown that astaxanthin has significant effects on acute liver injury in antioxidant, anti-inflammatory, immune regulation, inhibition of apoptosis, inhibition of liver fibrosis and other aspects. This paper reviews the research status of astaxanthin in toxic liver injury, in order to provide new ideas for further study of astaxanthin and new drug development of toxic liver injury.
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