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GDF15与女性妊娠呕吐的相关性研究进展
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Abstract:
妊娠呕吐(Nausea and Vomiting of Pregnancy, NVP)是女性在妊娠早期出现的早孕反应。症状的严重程度和持续时间根据孕妇个人体质等实际情况有所不同。少数孕妇呕吐反应比较剧烈导致体液失衡以及新陈代谢障碍，危及母婴生命安全。生长分化因子15 (Growth Differentiation Factor 15, GDF15)被发现在胎盘组织中特异性高表达，对维持妊娠和促进胎儿正常发育相当重要，且与妊娠呕吐关系密切。近年来国内外研究者从GDF15生理作用、遗传研究、动物试验、临床意义等不同角度去挖掘二者间的相关性。本文综述以上关于GDF15与妊娠呕吐的相关研究进展。
Nausea and vomiting of pregnancy (NVP) is an early pregnancy reaction that occurs in women during the first trimester of pregnancy. The severity and duration of symptoms vary according to the actual conditions of the pregnant woman, such as her personal physique. A small number of pregnant women vomiting reaction is more severe, resulting in body fluid imbalance and metabolic disorders, endangering the life safety of mothers and children. Growth differentiation factor 15 (GDF15) has been found to be specifically highly expressed in placental tissue and is important for maintaining pregnancy and promoting normal fetal development, and is closely associated with hyperemesis gravidarum. In recent years, researchers at home and abroad have explored the correlation between GDF15 and GDF15 from different perspectives such as physiological effects, genetic studies, animal tests and clinical significance. In this paper, we review the research progress of GDF15 and hyperemesis gravidarum.
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