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D2-40在胃癌中的研究进展及临床意义
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Abstract:
D2-40是种与癌胚抗原M2A特异性结合的单克隆抗体，仅存在于淋巴内皮细胞，可特异地标记淋巴管内皮细胞，具有很强的特异性和灵敏度。随着D2-40的应用，发现其在肺腺癌、乳腺癌、结直肠癌中可以作为独立的预后的因素。同时大量研究发现，胃癌患者预后不良的主要原因是淋巴道转移，D2-40可特异地标记淋巴管，显示胃癌中心及其周围的淋巴管密度，为胃癌的胃癌分期、淋巴结转移、组织学分型及早期治疗提供线索，有望成为胃癌的独立预后因素，为胃癌的治疗及预后提供有利线索。该文就D2-40在胃癌中的研究进展作一综述，为疾病的治疗及预后评估提供新的思路和策略。
D2-40 is a monoclonal antibody that binds specifically to carcinoembryonic antigen M2A, which is present only in lymphatic endothelial cells, and specifically labels lymphatic endothelial cells with high specificity and sensitivity. With the use of D2-40, it has been found to act as an independent prognosticator in lung adenocarcinoma, breast cancer, and colorectal cancer. Meanwhile, a large number of studies have found that the main reason for the poor prognosis of gastric cancer patients is lymphatic metastasis. D2-40 can specifically label lymphatic vessels and show the density of lymphatic vessels in the center of gastric cancer and its surroundings, which can provide clues for gastric cancer staging, lymph node metastasis, histological typing and early treatment of gastric cancer, and it is expected to become an independent prognostic factor of gastric cancer, which can provide favorable clues for the treatment and prognosis of gastric cancer. This article provides a review on the research progress of D2-40 in gastric cancer to provide new ideas and strategies for the treatment and prognostic evaluation of the disease.
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