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基于“毒损肾络”论治ANCA相关性血管炎肾损害
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Abstract:
“毒损肾络”率先由南征针对糖尿病肾病提出，主张从毒论治糖尿病肾病，确立益肾解毒，通络导邪的治疗法则。ANCA相关性血管炎肾损害的发病与湿、热、瘀诸毒交织有关，病位在肾络，病机特点为毒损肾络，毒邪壅遏、气血凝结、瘀毒阻络、络脉不通、变证从生，进而肾络瘀阻，肾气难复，酿为此病，据此治疗上主张解毒活血通络，佐以维护肾气，在临床上运用，效果显著。
“Toxin Damages Kidney Meridians” was first proposed by Nan Zheng for diabetic nephropathy, advocating the treatment of diabetic nephropathy from the perspective of toxin, establishing the treatment principles of nourishing kidney and detoxifying, promoting blood circulation and expelling pathogenic factors. The pathogenesis of ANCA-related vascular nephritis involves the intertwining of dampness, heat, and toxins, with the pathological location being the kidney meridians. The pathogenic mechanism is characterized by toxin damage to the kidney meridians, with toxin congestion, stagnation of Qi and blood, blockage of blood vessels, impairment of the flow of Qi and blood, and the emergence of complications. Consequently, the kidney meridians become obstructed, and it is difficult to restore the kidney Qi, leading to the development of this disease. Accordingly, the treatment advocates detoxification and blood-activating dredging of meridians, with the assistance of maintaining kidney Qi. This treatment has shown significant clinical effects.
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