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慢性阻塞性肺疾病相关性肺动脉高压的发病机制研究进展
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Abstract:
慢性阻塞性肺疾病(COPD)相关性肺动脉高压(PH)是一种影响肺血管结构和功能的慢性不可逆性病变。COPD患者长期缺氧的状态会逐渐使肺血管收缩并重构，进而形成PH，最终会导致右心衰竭，严重影响人民群众的身体健康及生活质量；在目前的研究中，COPD相关性PH的发病机制尚未完全阐明，肺血管重构、内皮损伤、肺血管收缩、炎症反应、血液高凝、遗传因素等都参与其中，本文对COPD相关性PH的发病机制研究进展进行了综述。
Pulmonary hypertension (PH) associated with chronic obstructive pulmonary disease (COPD) is a chronic irreversible disease that affects the structure and function of pulmonary blood vessels. Chronic hypoxia in COPD patients will gradually cause pulmonary blood vessels to constrict and restructure, thus forming pulmonary hypertension and eventually leading to right heart failure, which seriously affects people’s health and quality of life. In current studies, the pathogenesis of PH associated with COPD has not been fully elucidated, and pulmonary vascular remodeling, endothelial injury, pulmonary vasoconstriction, inflammatory response, blood hypercoagulability, and genetic factors are all involved. This paper reviews the progress of research on the pathogenesis of PH associated with COPD.
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