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Applied Physics 2024
OCT评估超声介导下表皮真皮层的光学参数变化规律的研究
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Abstract:
皮肤是光学成像诊断的主要靶器官之一，但皮肤组织的高散射特性限制了光学相干层析成像技术(OCT)的成像深度和扫描精度。利用高频超声结合光学透明剂对离体皮肤组织进行实时处理，协同光学透明剂进入生物组织。实验对比两种处理模式下的离体皮肤的OCT的相关参数的变化。PVP粘性改良80%PEG-400/PEG-200结合频率为1 MHz、功率1 W/cm2的高频超声处理离体皮肤组织后，真皮层散射系数在60分钟内降低0.27，与对照组相比，同比增加了3.3倍。证明高频超声能够有效改善OCAs的皮肤组织光学清除效率，提升OCT光学成像效果。
Skin is one of the main target organs for optical imaging diagnosis, but the high scattering properties of skin tissue limit the imaging depth and scanning accuracy of optical coherence tomography (OCT). Real-time processing of isolated skin tissues using high-frequency ultrasound combined with optical hyaluronics synergizes optical hyaluronics into biological tissues to improve the optical clearance of skin tissues. The changes in the relevant parameters of OCT of isolated skin in the two treatment modes were compared in the experiment. The dermal scattering coefficient decreased by 0.27 within 60 minutes after PVP viscosity-modified 80% PEG-400/PEG-200 combined with high-frequency ultrasound at a frequency of 1 MHz and a power of 1 W/cm2 was used for the treatment of isolated skin tissues. This is a year-on-year increase of 3.3-fold when compared with that of the control group. This result demonstrates that high-frequency ultrasound can effectively improve the optical removal efficiency of skin tissues with OCAs and enhance OCT optical imaging.
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