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抗肿瘤治疗所致骨髓抑制的研究与进展
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Abstract:
随着人类对肿瘤不断的攻克，化疗药物，免疫检查点抑制剂和靶向药物在治疗恶性肿瘤方面取得巨大进展，抗肿瘤药物所诱发的副作用主要有骨髓抑制、口腔炎、粘膜炎、腹泻和呕吐。其中，骨髓抑制是抗肿瘤治疗过程中最可能产生严重后果的副反应。本文将综述抗肿瘤治疗所致骨髓抑制的研究进展，明确抗肿瘤治疗后所致的骨髓抑制的病理变化，为治疗骨髓抑制的药物研发指出方向，为临床上对骨髓抑制预防性手段提供理论依据。
As humans continue to make strides in conquering tumors, significant progress has been made in the treatment of malignant tumors with chemotherapy drugs, immune checkpoint inhibitors, and targeted therapies. The side effects induced by anti-tumor drugs mainly include bone marrow suppression, oral mucositis, mucositis, diarrhea, and vomiting. Among them, bone marrow suppression is the most likely side effect to produce serious consequences during anti-tumor treatment. This article will review the research progress on bone marrow suppression induced by anti-tumor therapy, clarify the pathological changes of bone marrow suppression caused by anti-tumor treatment, point out directions for drug development to treat bone marrow suppression, and provide theoretical basis for preventive measures against bone marrow suppression in clinical practice.
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