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循环miRNAs作为急性缺血性卒中生物标记物和脑保护机制的研究进展
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Abstract:
MicroRNAs (miRNAs)是一类非编码RNA分子，在基因转录后调节急性缺血性中风(AIS)中发挥重要作用。由于miRNAs基因高度保守且在血液中稳定，并能通过调节靶基因的表达参与脑卒中的发生和进展。因此，miRNAs有望作为缺血性脑卒中诊断和预后的生物标志物。miRNAs通过减弱炎症反应，抑制氧化应激，抑制细胞凋亡，促进血管生成等途径来发挥脑保护作用，随着对miRNAs在AIS脑保护机制不断深入研究，它们潜在的治疗靶点可能成为新的治疗途径。
MicroRNAs (miRNAs) are a class of non coding RNA molecules that play an important role in post transcriptional regulation of acute ischemic stroke (AIS). Due to the high conservation and stability of miRNAs genes in the bloodstream, they can participate in the occurrence and progression of stroke by regulating the expression of target genes. Therefore, miRNAs are expected to serve as biomarkers for the diagnosis and prognosis of ischemic stroke. MiRNAs exert neuroprotective effects by reducing inflammatory response, inhibiting oxidative stress, inhibiting cell apoptosis, and promoting angiogenesis. With further research on the neuroprotective mechanisms of miRNAs in AIS, their potential therapeutic targets may become new therapeutic approaches.
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