Calcium-based biocomposite materials have a pivotal role in the biomedical field with their diverse properties and applications in combating challenging medical problems. The study states the development and characterization of Calcium-based biocomposites: Hydroxyapatite (HAP), and PVA-Gelatin-HAP films. For the preparation of Calcium-based biocomposites, an unconventional source, the waste material calcite stone, was used as calcium raw material, and by the process of calcination, calcium oxide was synthesized. From calcium oxide, HAP was prepared by chemical precipitation method, which was later added in different proportions to PVA-Gelatin solution and finally dried to form biocomposite films. Then the different properties of PVA/Gelatin/HAP composite, for instance, chemical, mechanical, thermal, and swelling properties due to the incorporation of various proportions of HAP in PVA-Gelatin solution, were investigated. The characterization of the HAP was conducted by X-ray Diffraction Analysis, and the characterization of HAP-PVA-Gelatin composites was done by Fourier Transform Infrared Spectroscopy, Thermomechanical Analysis, Tensile test, Thermogravimetric Differential Thermal Analysis, and Swelling Test. The produced biocomposite films might have applications in orthopedic implants, drug delivery, bone tissue engineering, and wound healing.
References
[1]
Ashby, M.F., Shercliff, H. and Cebon, D. (2014) Materials Engineering, Science, Processing and Design. https://ftp.idu.ac.id/wp-content/uploads/ebook/tdg/TEKNOLOGI REKAYASA MATERIAL PERTAHANAN/Materials_ Engineering, Science, Processing and Design ( PDFDrive ).pdf
[2]
(2019) What Is Material—Nuclear Power. https://www.nuclear-power.com/nuclear-engineering/materials-science/what-is-material-definition-of-materials/
[3]
Kiran, A.S.K. and Ramakrishna, S. (2021) An Introduction to Biomaterials Science and Engineering. World Scientific Publishing Company, Singapore. https://doi.org/10.1142/12038
[4]
Basak, P., Pahari, P., Das, P., Das, N., Samanta, S.K. and Roy, S. (2018) Synthesis and Characterisation of Gelatin-PVA/Hydroxyapetite (HAP) Composite for Medical Applications. 1st International Conference on Advanced Engineering Functional Materials (ICAEFM), 21-23 September 2018, GITA, Bhubaneswar, Odisha, India. https://doi.org/10.1088/1757-899X/410/1/012021
[5]
MohdPu’ad, N.A.S., Koshy, P., Abdullah, H.Z., Idris, M.I. and Lee, T.C. (2019) Syntheses of Hydroxyapatite from Natural Sources. Heliyon, 5, e01588. https://doi.org/10.1016/j.heliyon.2019.e01588
[6]
Londoño-Restrepo, S.M., Ramirez-Gutierrez, C.F., Del Real, A., Rubio-Rosas, E., and Rodriguez-García, M.E. (2016) Study of Bovine Hydroxyapatite Obtained by Calcination at Low Heating Rates and Cooled in Furnace Air. Journal of Materials Science, 51, 4431-4441. https://doi.org/10.1007/s10853-016-9755-4
[7]
Sunil, B. and Jagannatham, M. (2016) Producing Hydroxyapatite from Fish Bones by Heat Treatment. Materials Letters, 185, 411-414. https://doi.org/10.1016/j.matlet.2016.09.039
[8]
Razali, N.A.I.M., Pramanik, S., Osman, N.A.A. and Pingguan-Murphy, B. (2016) Conversion of Calcite from Cockle Shells to Bioactive Nanorod Hydroxyapatite for Biomedical Applications. Journal of Ceramic Processing Research, 17, 699-706. https://www.researchgate.net/publication/309113640_Conversion_of_calcite_from_cockle_shells_to_bioactive_nanorod_hydroxyapatite_for_biomedical_applications
[9]
Al-Mamun, A., Haque, P., Debnath, T., Rahman, M.F., Islam, J.M.M., Rahman, M.M. and Khan, M.A. (2018) γ-Irradiated Gelatin and Polyvinyl Alcohol Films as Artificial Articular Cartilage. Journal of Thermoplastic Composite Materials, 33, 614-627. https://doi.org/10.1177/0892705718808555
[10]
Qadir, Md.R., Hossan, J., Gafur, M.A. and Karim, M.M. (2014) Preparation and Characterization of Gelatin-Hydroxyapatite Composite for Bone Tissue Engineering. International Journal of Engineering & Technology Sciences, 14, 24-32. https://www.researchgate.net/publication/271392529_Preparation_and_Characterization_of_Gelatin-Hydroxyapatite_Composite_for_Bone_Tissue_Engineering
Kim, H., Hwangbo, H., Koo, Y. and Kim, G. (2020) Fabrication of Mechanically Reinforced Gelatin/Hydroxyapatite Bio-Composite Scaffolds by Core/Shell Nozzle PRINTING for Bone Tissue Engineering. International Journal of Molecular Sciences, 21, Article 3401. https://doi.org/10.3390/ijms21093401
[14]
Jipa, I., Stoica, A., Stroescu, M., Dobre, L.-M., Dobre, T., Jinga, S. and Tardei, C. (2012) Potassium Sorbate Release from Poly(vinyl Alcohol)-Bacterial Cellulose Films. Chemical Papers, 66, 138-143. https://doi.org/10.2478/s11696-011-0068-4
[15]
Bodirlau, R., Teaca, C.-A. and Spiridon, I. (2013) Influence of Natural Fillers on the Properties of Starch-Based Biocomposite Films. Composites Part B: Engineering, 44, 575-583. https://doi.org/10.1016/j.compositesb.2012.02.039
[16]
Kamieniak, J., Morgado, E.B., Foster, C.W. and Banks, C.E. (2016) High Yield Synthesis of Hydroxyapatite (HAP) and Palladium Doped HAP via a Wet Chemical Synthetic Route. Catalysts, 6, Article 119. https://www.researchgate.net/publication/305811625_High_Yield_Synthesis_of_Hydroxyapatite_HAP_and_Palladium_Doped_HAP_via_a_Wet_Chemical_Synthetic_Route https://doi.org/10.3390/catal6080119