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Pharmacy Information 2024
肝窦内皮细胞在NAFLD疾病中的作用
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Abstract:
非酒精性脂肪性肝病(Non-alcoholic fatty liver disease, NAFLD)是一种发病率较高的常见慢性肝病，其发病机制较为复杂，为药物研发带来困难。肝窦内皮细胞(liver sinusoidal endothelial cells, LSECs)位于肝血窦表面，是肝脏与血液接触的第一道防线，也是肝脏中含量最多的非实质细胞。LSECs作为肝脏内高度特化的内皮细胞，由于其独特的结构以及功能在NAFLD的发生与进展中都扮演了重要的角色，并且可以为NAFLD药物研发带来新思路。本文主要针对LSECs及其功能障碍在NAFLD中参与到的发病机制进行综述，并对以改善LSECs功能障碍为靶点的药物进行介绍。
Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease with a high incidence rate, and its pathogenesis is complex, posing challenges for drug development. Liver sinusoidal endothelial cells (LSECs) are located on the surface of the liver sinusoids, serving as the first line of defense between the liver and blood, and they are the most abundant non-parenchymal cells in the liver. LSECs, as highly specialized endothelial cells in the liver, play an important role in the occurrence and progression of NAFLD due to their unique structure and function, offering new insights for NAFLD drug development. This review focuses on the involvement of LSECs and their functional impairments in the pathogenesis of NAFLD, and introduces drugs that target improving LSECs dysfunction.
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