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基于介孔聚多巴胺纳米球的光热与化学动力学协同治疗
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Abstract:
自由基是一种新型且有前景的乏氧肿瘤治疗方式。在本文中，利用介孔聚多巴胺(mPDA)纳米球结合不依赖于氧气的自由基发生器(AIPH)构建了一种纳米治疗剂mPDA@AIPH，从而实现高效的肿瘤治疗。在近红外光照射下，mPDA产生的光热效应会诱导AIPH快速分解，释放出具有细胞毒性的烷基自由基，从而导致细胞死亡。这种方式产生的自由基对诱导乏氧肿瘤细胞凋亡非常有效。
Free radicals have emerged as new-type and promising candidates for hypoxic tumor treatment. Herein, a biocompatible mesoporous polydopamine (mPDA) nanosphere is developed by combining an oxygen-independent radicals generator (AIPH) for efficient cancer therapy, denoted as mPDA@AIPH. Upon near-infrared irradiation, the photothermal effect generated by mPDA will induce rapid decomposition of AIPH to release cytotoxic alkyl radicals, leading to cancer cell death. The free radicals produced in this way are highly effective in inducing apoptosis in hypoxic cancer cells.
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