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胆固醇在肿瘤及免疫细胞中的研究进展
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Abstract:
胆固醇是细胞内重要的脂质，是细胞必不可少的膜结构的成分。细胞内的胆固醇通过摄取与细胞内合成来产生。胆固醇在癌症发展过程中所起的作用以及针对胆固醇的治疗一直是人们关注的焦点。胆固醇具有影响肿瘤微环境中肿瘤细胞及免疫细胞的功能。本文对胆固醇如何影响肿瘤微环境中肿瘤细胞及免疫细胞进行总结，并展望了通过干扰细胞胆固醇代谢的肿瘤免疫疗法。
Cholesterol is an important lipid in the cell and is an essential component of the membrane structure of the cell. Intracellular cholesterol is produced through uptake and intracellular synthesis. The role that cholesterol plays in the development of cancer and the treatments that target cholesterol have been the focus of much attention. Cholesterol can affect the function of tumor cells and immune cells in the tumor microenvironment. This article summarizes how cholesterol affects tumor cells and immune cells in the tumor microenvironment, and looks forward to tumor immunotherapy by interfering with cellular cholesterol metabolism.
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