|
|
硼中子俘获治疗应用及展望
|
Abstract:
癌症的发病率和死亡率一直保持在相对比较高的水平，且有逐年上升的趋势，而现在精准放疗的概念逐渐引进现代医疗，所以一种新的癌症治疗方法——硼中子俘获疗法(boron neutron capture therapy, BNCT)值得进一步发展，尽管在该方法的研究中存在诸多问题，但BNCT的发展和临床应用前景十分广阔，并且符合现代医疗的观点。本文章介绍了新技术BNCT的原理及其发展，目前可用的硼递体的特点，以及BNCT的临床应用。
The incidence and mortality of cancer have been maintained at a relatively high level and have been increasing year by year, and now the concept of precision radiotherapy is gradually introduced into modern medicine, so a new cancer treatment method, boron neutron capture therapy (BNCT), is worthy of further development, although there are many problems in the research of this method, the development and clinical application of BNCT are very promising, and it is in line with the perspective of modern medicine. This article describes the principles and development of the new technology BNCT, the characteristics of currently available boron transmitters, and the clinical application of BNCT.
| [1] | Chadwick, J. (1932) The Existence of a Neutron. PRSL. |
| [2] | Barth, R.F., Zhang, Z. and Liu, T. (2018) A Realistic Appraisal of Boron Neutron Capture Therapy as a Cancer Treatment Modality. Cancer Communications, 38, 1-7. https://doi.org/10.1186/s40880-018-0280-5 |
| [3] | Locher, G. (1936) Biological Effects and Therapeutic Possibilities of Neutrons. The American Journal of Roentgenology Radium Therapy, 36, 1-13. |
| [4] | Farr, L.E., Sweet, W.H., Locksley, H.B. and Robertson, J.S. (1954) Neutron Capture Therapy of Gliomas Using Boron. Transactions of the American Neurological Association, 79, 110-113. |
| [5] | Hatanaka, H. (1990) Clinical Results of Boron Neutron Capture Therapy. Basic Life Sciences, 54, 15-21. https://doi.org/10.1007/978-1-4684-5802-2_2 |
| [6] | Mishima, Y., Ichihashi, M., Hatta, S., Honda, C., Yamamura, K., Nakagawa, T., et al. (1989) First Human Clinical Trial of Melanoma Neutron Capture. Diagnosis and Therapy. Strahlentherapie und Onkologie, 165, 251-254. |
| [7] | Nedunchezhian, K. (2016) Boron Neutron Capture Therapy—A Literature Review. Journal of Clinical and Diagnostic Research, 10, ZE01-ZE04. https://doi.org/10.7860/JCDR/2016/19890.9024 |
| [8] | Suzuki, M. (2019) Boron Neutron Capture Therapy (BNCT): A Unique Role in Radiotherapy with a View to Entering the Acceleratorbased BNCT Era. International Journal of Clinical Oncology, 25, 43-50. https://doi.org/10.1007/s10147-019-01480-4 |
| [9] | Kawabata, S., Miyatake, S.I., Nonoguchi, N., Hiramatsu, R., Iida, K., Miyata, S., et al. (2009) Survival Benefit from Boron Neutron Capturetherapy for the Newly Diagnosed Glioblastoma Patients. Applied Radiation and Isotopes, 67, S15-S18. https://doi.org/10.1016/j.apradiso.2009.03.015 |
| [10] | Chandra, S., Ahmad, T., Barth, R.F. and Kabalka, G.W. (2014) Quantitative Evaluation of Boron Neutron Capture Therapy (BNCT) Drugs for Boron Delivery and Retention at Subcellular-Scale Resolution in Human Glioblastoma Cells with Imaging Secondary Ion Mass Spectrometry (SIMS). Journal of Microscopy, 254, 146-156. https://doi.org/10.1111/jmi.12126 |
| [11] | Carlsson, J., Forssell-Aronsson, E., Glimelius, B. and Swedish Cancer Society Investigation Group (2002) Radiation Therapy through Activation of Stable Nuclides. Acta Oncologica, 41, 629-634. https://doi.org/10.1080/028418602321028238 |
| [12] | Taskaev, S.Y. (2012) VITA Means Life. Boron Neutron Capture Therapy of Cancer. Science First Hand, 32, N2. |
| [13] | Barth, R.F., Mi, P. and Yang, W. (2018) Boron Delivery Agents for Neutron Capture Therapy of Cancer. Cancer Communications, 38, 1-15. https://doi.org/10.1186/s40880-018-0299-7 |
| [14] | Barth, R.F.H., Vicente, M.G., Harling, O.K., Kiger, W., Riley, K.J., Binns, P.J., et al. (2012) Current Status of Boron Neutron Capture Therapy of High Grade Gliomas and Recurrent Head and Neck Cancer. Radiation Oncology, 7, Article No. 146. https://doi.org/10.1186/1748-717X-7-146 |
| [15] | Kato, I., Fujita, Y., Maruhashi, A., Kumada, H., Ohmae, M., Kirihata, M., et al. (2009) Effectiveness of Boron Neutron Capture Therapy for Recurrent Head and Neck Malignancies. Applied Radiation and Isotopes, 67, S37-S42. https://doi.org/10.1016/j.apradiso.2009.03.103 |
| [16] | Wongthai, P., Hagiwara, K., Miyoshi, Y., Wiriyasermkul, P., Wei, L., Ohgaki, R., et al. (2015) Boronophenylalanine, a Boron Delivery Agent for Boron Neutron Capture Therapy, Is Transported by ATB0, , LAT1 and LAT2. Cancer Science, 106, 279-286. https://doi.org/10.1111/cas.12602 |
| [17] | Hanaoka, K., Watabe, T., Naka, S., Kanai, Y., Ikeda, H., Horitsugi, G., et al. (2014) FBPA PET in Boron Neutron Capture Therapy for Cancer: Prediction of 10B Concentration in the Tumor and Normal Tissue in a Rat Xenograft Model. EJNMMI Research, 4, Article No. 70. https://doi.org/10.1186/s13550-014-0070-2 |
| [18] | Watabe, T., Hanaoka, K., Naka, S., Kanai, Y., Ikeda, H., Aoki, M., et al. (2017) Practical Calculation Method to Estimate the Absolute Boron Concentration in Tissues Using 18F-FBPA PET. Annals of Nuclear Medicine, 31, 481-485. https://doi.org/10.1007/s12149-017-1172-5 |
| [19] | Yoshimoto, M., Honda, N., Kurihara, H., Hiroi, K., Nakamura, S., Ito, M., et al. (2018) Non-Invasive Estimation of 10 B-4-BoronoL-Phenylalanine-Derived Boron Concentration in Tumors by PET Using 4-Borono-2-18 F-Fluoro-Phenylalanine. Cancer Science, 109, 1617-1626. https://doi.org/10.1111/cas.13553 |
| [20] | Yoshimoto, M., Kurihara, H., Honda, N., Kawai, K., Ohe, K., Fujii, H., et al. (2013) Predominant Contribution of L-Type Amino Acid Transporter to 4-Borono-2-18F-Fluoro-Phenylalanine Uptake in Human Glioblastoma Cells. Nuclear Medicine and Biology, 40, 625-629. https://doi.org/10.1016/j.nucmedbio.2013.02.010 |
| [21] | Farhood, B., Samadian, H., Ghorbani, M., Zakariaee, S.S. and Knaup, C. (2018) Physical, Dosimetric and Clinical Aspects and Delivery Systems in Neutron Capture Therapy. Reports of Practical Oncology & Radiotherapy, 23, 462-473. https://doi.org/10.1016/j.rpor.2018.07.002 |
| [22] | Goodman, J.H., Yang, W., Barth, R.F., Gao, Z., Boesel, C.P., Staubus, A.E., et al. (2000) Boron Neutron Capture Therapy of Brain Tumors: Biodistribution, Pharmacokinetics, and Radiation Dosimetry Sodium Borocaptate in Patients with Gliomas. Neurosurgery, 47, 608-621. https://doi.org/10.1227/00006123-200009000-00016 |
| [23] | Koivunoro, H., Hippel？inen, E., Auterinen, I., Kankaanranta, L., Kulvik, M., Laakso, J., et al. (2015) Biokinetic Analysis of Tissue Boron(10B) Concentrations of Glioma Patients Treated with BNCT in Finland. Applied Radiation and Isotopes, 106, 189-194. https://doi.org/10.1016/j.apradiso.2015.08.014 |
| [24] | Ferrari, C., Zonta, C., Cansolino, L., Clerici, A.M., Gaspari, A., Altieri, S., et al. (2009) Selective Uptake of P-Boronophenylalanine by Osteosarcoma Cells for Boron Neutron Capture Therapy. Applied Radiation and Isotopes, 67, S341-S344. https://doi.org/10.1016/j.apradiso.2009.03.059 |
| [25] | Diaz, A.Z. (2003) Assessment of the Results from the Phase I/II Boron Neutron Capture Therapy Trials at the Brookhaven National Laboratory from a Clinician’s Point of View. Journal of Neuro-Oncology, 62, 101-109. https://doi.org/10.1007/BF02699937 |
| [26] | Carpano, M., Perona, M., Rodriguez, C., Nievas, S., Olivera, M., Santa Cruz, G.A., et al. (2015) Experimental Studies of Boronophenylalanine (10BPA) Biodistribution for the Individual Application of Boron Neutron Capture Therapy (BNCT) for Malignant Melanoma Treatment. International Journal of Radiation Oncology, Biology, Physics, 93, 344-352. https://doi.org/10.1016/j.ijrobp.2015.05.039 |
| [27] | Fuentes, I., García-Mendiola, T., Sato, S., Pita, M., Nakamura, H., Lorenzo, E., et al. (2018) Metallacarboranes on the Road to Anticancer Therapies: Cellular Uptake, DNA Interaction, and Biological Evaluation of Cobaltabisdicarbollide [COSAN]？. Chemistry: A European Journal, 24, 17239-17254. https://doi.org/10.1002/chem.201803178 |
| [28] | Suzuki, M., Kato, I., Aihara, T., Hiratsuka, J., Yoshimura, K., Niimi, M., et al. (2014) Boron Neutron Capture Therapy Outcomes for Advanced or Recurrent Head and Neck Cancer. Journal of Radiation Research, 55, 146-153. https://doi.org/10.1093/jrr/rrt098 |
| [29] | Miyatake, S.I., Kawabata, S., Hiramatsu, R., Kuroiwa, T., Suzuki, M. and Ono, K. (2018) Boron Neutron Capture Therapy of Malignant Gliomas. In: Progress in Neurological Surgery, 48-56. https://doi.org/10.1159/000469679 |
| [30] | Wang, L.W., Liu, Y.W.H., Chou, F.I. AND Jiang, S.H. (2018) Clinical Trials for Treating Recurrent Head and Neck Cancer with Boron Neutron Capture Therapy Using the Tsing-Hua Open Pool Reactor. Cancer Communications, 38, 1-7. https://doi.org/10.1186/s40880-018-0295-y |
| [31] | Yanagie, H., Higashi, S., Seguchi, K., Ikushima, I., Fujihara, M., Nonaka, Y., et al. (2014) Pilot Clinical Study of Boron Neutron Capture Therapy for Recurrent Hepatic Cancer Involving the Intra-Arterial Injection of a 10BSH-Containing WOW Emulsion. Applied Radiation and Isotopes, 88, 32-37. https://doi.org/10.1016/j.apradiso.2014.01.014 |
| [32] | Suzuki, M., Suzuki, O., Sakurai, Y., Tanaka, H., Kondo, N., Kinashi, Y., et al. (2012) Reirradiation for Locally Recurrent Lung Cancer in the Chest Wall with Boron Neutron Capture Therapy (BNCT). International Cancer Conference Journal, 1, 235-238. https://doi.org/10.1007/s13691-012-0048-8 |
| [33] | Koivunoro, H., Kankaanranta, L., Sepp？l？, T., Haapaniemi, A., M？kitie, A. AND Joensuu, H. (2019) Boron Neutron Capture Therapy for Locally Recurrent Head and Neck Squamous Cell Carcinoma: An Analysis of Dose Response and Survival. Radiotherapy & Oncology, 137, 153-158. https://doi.org/10.1016/j.radonc.2019.04.033 |
| [34] | Hiratsuka, J., Kamitani, N., Tanaka, R., Yoden, E., Tokiya, R., Suzuki, M., et al. (2018) Boron Neutron Capture Therapy for Vulvar Melanoma and Genital Extramammary Paget’s Disease with Curative Responses. Cancer Communications, 38, 1-10. https://doi.org/10.1186/s40880-018-0297-9 |
| [35] | Komori, T. (2017) The 2016 WHO Classification of Tumours of the Central Nervous System: The Major Points of Revision. Neurologia Medico-Chirurgica, 57, 301-311. https://doi.org/10.2176/nmc.ra.2017-0010 |
| [36] | Blot, W.J., McLaughlin, J.K., Winn, D.M., Austin, D.F., Greenberg, R.S., Preston-Martin, S., et al. (1988) Smoking and Drinking in Relation to Oral and Pharyngeal Cancer. Cancer Research, 48, 3282-3287. |
| [37] | Leonard, B., Brand, T.M., O’Keefe, R.A., Lee, E.D., Zeng, Y., Kemmer, J.D., et al. (2018) BET Inhibition Overcomes Receptor Tyrosine Kinase-Mediated Cetuximab Resistance in HNSCC. Cancer Research, 78, 4331-4343. https://doi.org/10.1158/0008-5472.CAN-18-0459 |
| [38] | Fujita, Y., Kato, I., Iwai, S., Ono, K., Suzuki, M., Sakurai, Y., et al. (2009) Role of P53 Mutation in the Effect of Boron Neutron Capture Therapy on Oral Squamous Cell Carcinoma. Radiation Oncology, 4, Article No. 63. https://doi.org/10.1186/1748-717X-4-63 |
| [39] | Zhou, G., Liu, Z. and Myers, J.N. (2016) TP53 Mutations in Head and Neck Squamous Cell Carcinoma and Their Impact on Disease Progression and Treatment Response. Journal of Cellular Biochemistry, 117, 2682-2692. https://doi.org/10.1002/jcb.25592 |
| [40] | Aihara, T., Morita, N., Kamitani, N., Ono, K., Hiratsuka, J. and Harada, T. (2014) BNCT for Advanced or Recurrent Head and Neck Cancer. Applied Radiation and Isotopes, 88, 12-15. https://doi.org/10.1016/j.apradiso.2014.04.007 |
| [41] | Haapaniemi, A., Kankaanranta, L., Saat, R., Koivunoro, H., Saarilahti, K., M？kitie, A., et al. (2016) Boron Neutron Capture Therapy in the Treatment of Recurrent Laryngeal Cancer. International Journal of Radiation Oncology, Biology, Physics, 95, 404-410. https://doi.org/10.1016/j.ijrobp.2015.11.010 |
| [42] | Kankaanranta, L., Sepp？l？, T., Koivunoro, H., Saarilahti, K., Atula, T., Collan, J., et al. (2012) Boron Neutron Capture Therapy in the Treatment of Locally Recurred Head-And-Neck Cancer: Final Analysis of a Phase I/II Trial. International Journal of Radiation Oncology, Biology, Physics, 82, E67-E75. https://doi.org/10.1016/j.ijrobp.2010.09.057 |
| [43] | Bobos, M. (2021) Histopathologic Classification and Prognostic Factors of Melanoma: A 2021 Update. Italian Journal of Dermatology and Venereology, 156, 300-321. https://doi.org/10.23736/S2784-8671.21.06958-3 |
| [44] | Arnold, M., Singh, D., Laversanne, M., et al. (2022) Global Burden of Cutaneous Melanoma in 2020 and Projections to 2040. JAMA Dermatology, 158, 495-503. https://doi.org/10.1001/jamadermatol.2022.0160 |
| [45] | Alberti, D., Deagostino, A., Toppino, A., Protti, N., Bortolussi, S., Altieri, S., et al. (2018) An Innovative Therapeutic Approach for Malignant Mesothelioma Treatment Based on the Use of Gd/Boron Multimodal Probes for MRI Guided BNCT. Journal of Controlled Release, 280, 31-38. https://doi.org/10.1016/j.jconrel.2018.04.043 |
| [46] | Van Meerbeeck, J.P., Scherpereel, A., Surmont, V.F. and Baas, P. (2011) Malignant Pleural Mesothelioma: The Standard of Care and Challenges for Future Management. Critical Reviews in Oncology/Hematology, 78, 92-111. https://doi.org/10.1016/j.critrevonc.2010.04.004 |
| [47] | R？e, O.D. and Stella, G.M. (2015) Malignant Pleural Mesothelioma: History, Controversy and Future of a Manmade Epidemic. European Respiratory Review, 24, 115-131. https://doi.org/10.1183/09059180.00007014 |
| [48] | Lagniau, S., Lamote, K., Van Meerbeeck, J.P. and Vermaelen, K.Y. (2017) Biomarkers for Early Diagnosis of Malignant Mesothelioma: Do We Need another Moonshot? Oncotarget, 8, 53751-53762. https://doi.org/10.18632/oncotarget.17910 |
