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用于肿瘤诊疗中的四氧化三铁(Fe3O4)纳米颗粒表面修饰
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Abstract:
近年来多功能磁性纳米颗粒及其衍生复合纳米材料引起了多模态成像及肿瘤协同治疗的关注。其中四氧化三铁(Fe3O4)纳米颗粒因其固有的特性而能够实现磁共振成像(MRI)、磁热疗(MHT)及药物递送。不同尺寸的Fe3O4纳米颗粒可以通过几种不同的方式制备，并且在其表面加以修饰可以提高生物相容性及肿瘤靶向性能，最终提高MRI成像信号及治疗效果。本文回顾了几种经典的Fe3O4纳米颗粒制备方式及几种表面修饰手段。之后阐述了其在肿瘤诊疗中的应用并且讨论了Fe3O4纳米颗粒仍然存在的问题。为读者了解多功能的Fe3O4纳米颗粒在肿瘤诊疗中的应用提供参考。
In recent years, multifunctional magnetic nanoparticles and their derived composite nanomaterials have attracted the attention of multimodal imaging and collaborative therapy of tumors. Among them, Fe3O4 nanoparticles are known for their inherent magnetic resonance imaging (MRI), magnetic hyperthermia (MHT), and drug delivery capabilities. Fe3O4 nanoparticles in different sizes can be prepared in several different methods. In addition, their surface modifications can improve biocompatibility and tumor-targeting performance, which leads to improved MRI imaging signals and therapeutic effects. In this paper, several classical preparation approaches of Fe3O4 nanoparticles and several surface modification methods are reviewed. Then, the application of Fe3O4 nanoparticles in cancer theranostics was described, and the limitations of Fe3O4 nanoparticles in nanomedicine were discussed. This paper provides a reference for readers to understand the application of multifunctional Fe3O4 nanoparticles in cancer theranostics.
| [1] | Jin, H., Qian, Y., Dai, Y., et al. (2016) Magnetic Enrichment of Dendritic Cell Vaccine in Lymph Node with Fluorescent-Magnetic Nanoparticles Enhanced Cancer Immunotherapy. Theranostics, 6, 2000-2014. https://doi.org/10.7150/thno.15102 |
| [2] | Fan, C.-H., Cheng, Y.-H., Ting, C.-Y., et al. (2016) Ultrasound/Magnetic Targeting with SPIO-DOX-Microbubble Complex for Image-Guided Drug Delivery in Brain Tumors. Theranostics, 6, 1542-1556. https://doi.org/10.7150/thno.15297 |
| [3] | Chandrasekharan, P., Tay, Z.W., Hensley, D., et al. (2020) Using Magnetic Particle Imaging Systems to Localize and Guide Magnetic Hyperthermia Treatment: Tracers, Hardware, and Future Medical Applications. Theranostics, 10, 2965-2981. https://doi.org/10.7150/thno.40858 |
| [4] | Li, S., Shang, L., Xu, B., et al. (2019) A Nanozyme with Photo-Enhanced Dual Enzyme-Like Activities for Deep Pancreatic Cancer Therapy. Angewandte Chemie International Edition, 58, 12624-12631. https://doi.org/10.1002/anie.201904751 |
| [5] | Curcio, A., Silva, A.K.A., Cabana, S., et al. (2019) Iron Oxide Nanoflowers @ CuS Hybrids for Cancer Tri-Therapy: Interplay of Photothermal Therapy, Magnetic Hyperthermia and Photodynamic Therapy. Theranostics, 9, 1288-1302. https://doi.org/10.7150/thno.30238 |
| [6] | Mukherjee, S., Sonanini, D., Maurer, A., et al. (2019) The Yin and Yang of Imaging Tumor Associated Macrophages with PET and MRI. Theranostics, 9, 7730-7748. https://doi.org/10.7150/thno.37306 |
| [7] | Karimian-Jazi, K., Münch, P., Alexander, A., et al. (2020) Monitoring Innate Immune Cell Dynamics in the Glioma Microenvironment by Magnetic Resonance Imaging and Multiphoton Microscopy (MR-MPM). Theranostics, 10, 1873-1883. https://doi.org/10.7150/thno.38659 |
| [8] | Reddy, L.H., Arias, J.L., Nicolas, J., et al. (2012) Magnetic Nanoparticles: Design and Characterization, Toxicity and Biocompatibility, Pharmaceutical and Biomedical Applications. Chemical Reviews, 112, 5818-5878. https://doi.org/10.1021/cr300068p |
| [9] | Shen, L., Li, B. and Qiao, Y. (2018) Fe3O4 Nanoparticles in Targeted Drug/Gene Delivery Systems. Materials, 11, Article 324. https://doi.org/10.3390/ma11020324 |
| [10] | Han, C., Zhao, D., Deng, C., et al. (2012) A Facile Hydrothermal Synthesis of Porous Magnetite Microspheres. Materials Letters, 70, 70-72. https://doi.org/10.1016/j.matlet.2011.11.115 |
| [11] | Roca, A.G., Morales, M.P., O’Grady, K., et al. (2006) Structural and Magnetic Properties of Uniform Magnetite Nanoparticles Prepared by High Temperature Decomposition of Organic Precursors. Nanotechnology, 17, 2783-2788. https://doi.org/10.1088/0957-4484/17/11/010 |
| [12] | Gu, T., Zhang, Y., Khan, S.A., et al. (2019) Continuous Flow Synthesis of Superparamagnetic Nanoparticles in Reverse Miniemulsion Systems. Colloid and Interface Science Communications, 28, 1-4. https://doi.org/10.1016/j.colcom.2018.10.005 |
| [13] | Bao, Y., Sherwood, J.A. and Sun, Z. (2018) Magnetic Iron Oxide Nanoparticles as T1 Contrast Agents for Magnetic Resonance Imaging. Journal of Materials Chemistry C, 6, 1280-1290. https://doi.org/10.1039/C7TC05854C |
| [14] | Grillo, R., Rosa, A.H. and Fraceto, L.F. (2015) Engineered Nanoparticles and Organic Matter: A Review of the State-of-the-Art. Chemosphere, 119, 608-619. https://doi.org/10.1016/j.chemosphere.2014.07.049 |
| [15] | Wang, X., Tu, Q., Zhao, B., et al. (2013) Effects of Poly(L-Lysine)-Modified Fe3O4 Nanoparticles on Endogenous Reactive Oxygen Species in Cancer Stem Cells. Biomaterials, 34, 1155-1169. https://doi.org/10.1016/j.biomaterials.2012.10.063 |
| [16] | Wang, C., Wang, Y., Xiao, W., et al. (2023) Carboxylated Superparamagnetic Fe3O4 Nanoparticles Modified with 3-Amino Propanol and Their Application in Magnetic Resonance Tumor Imaging. BMC Cancer, 23, Article No. 54. https://doi.org/10.1186/s12885-023-10514-0 |
| [17] | Zhang, Y., Ning, R., Wang, W., et al. (2022) Synthesis of Fe3O4/PDA Nanocomposites for Osteosarcoma Magnetic Resonance Imaging and Photothermal Therapy. Frontiers in Bioengineering and Biotechnology, 10, Article 844540. https://doi.org/10.3389/fbioe.2022.844540 |
| [18] | Xu, S., Yang, F., Zhou, X., et al. (2015) Uniform PEGylated PLGA Microcapsules with Embedded Fe3O4 Nanoparticles for US/MR Dual-Modality Imaging. ACS Applied Materials & Interfaces, 7, 20460-20468. https://doi.org/10.1021/acsami.5b06594 |
| [19] | Illés, E., Tombácz, E., Szekeres, M., et al. (2015) Novel Carboxylated PEG-Coating on Magnetite Nanoparticles Designed for Biomedical Applications. Journal of Magnetism and Magnetic Materials, 380, 132-139. https://doi.org/10.1016/j.jmmm.2014.10.146 |
| [20] | Bilal, M., Iqbal, H.M.N., Adil, S.F., et al. (2022) Surface-Coated Magnetic Nanostructured Materials for Robust Bio-Catalysis and Biomedical Applications—A Review. Journal of Advanced Research, 38, 157-177. https://doi.org/10.1016/j.jare.2021.09.013 |
| [21] | Li, J., Hu, Y., Yang, J., et al. (2015) Hyaluronic Acid-Modified Fe3O4@Au Core/Shell Nanostars for Multimodal Imaging and Photothermal Therapy of Tumors. Biomaterials, 38, 10-21. https://doi.org/10.1016/j.biomaterials.2014.10.065 |
| [22] | Neamtu, M., Nadejde, C., Hodoroaba, V.-D., et al. (2018) Functionalized Magnetic Nanoparticles: Synthesis, Characterization, Catalytic Application and Assessment of Toxicity. Scientific Reports, 8, Article No. 6278. https://doi.org/10.1038/s41598-018-24721-4 |
| [23] | Kim, J., Kim, H.S., Lee, N., et al. (2008) Multifunctional Uniform Nanoparticles Composed of a Magnetite Nanocrystal Core and a Mesoporous Silica Shell for Magnetic Resonance and Fluorescence Imaging and for Drug Delivery. Angewandte Chemie International Edition, 47, 8438-8441. https://doi.org/10.1002/anie.200802469 |
| [24] | Lin, J., Xin, P., An, L., et al. (2019) Fe3O4-ZIF-8 Assemblies as PH and Glutathione Responsive T2-T1 Switching Magnetic Resonance Imaging Contrast Agent for Sensitive Tumor Imaging in vivo. Chemical Communications, 55, 478-481. https://doi.org/10.1039/C8CC08943D |
| [25] | Thanuja, M.Y., Anupama, C. and Ranganath, S.H. (2018) Bioengineered Cellular and Cell Membrane-Derived Vehicles for Actively Targeted Drug Delivery: So Near and Yet So Far. Advanced Drug Delivery Reviews, 132, 57-80. https://doi.org/10.1016/j.addr.2018.06.012 |
| [26] | Hu, C.-M.J., Zhang, L., Aryal, S., et al. (2011) Erythrocyte Membrane-Camouflaged Polymeric Nanoparticles as a Biomimetic Delivery Platform. Proceedings of the National Academy of Sciences, 108, 10980-10985. https://doi.org/10.1073/pnas.1106634108 |
| [27] | Yao, C., Wang, W., Wang, P., et al. (2018) Near-Infrared Upconversion Mesoporous Cerium Oxide Hollow Biophotocatalyst for Concurrent PH-/H2O2-Responsive O2-Evolving Synergetic Cancer Therapy. Advanced Materials, 30, Article ID: 1704833. https://doi.org/10.1002/adma.201704833 |
| [28] | Rao, L., Bu, L.-L., Meng, Q.-F., et al. (2017) Antitumor Platelet-Mimicking Magnetic Nanoparticles. Advanced Functional Materials, 27, Article ID: 1604774. https://doi.org/10.1002/adfm.201604774 |
| [29] | Huang, J., Wang, L., Lin, R., et al. (2013) Casein-Coated Iron Oxide Nanoparticles for High MRI Contrast Enhancement and Efficient Cell Targeting. ACS Applied Materials & Interfaces, 5, 4632-4639. https://doi.org/10.1021/am400713j |
| [30] | Zhang, Y.N., Liu, L., Li, W., et al. (2023) PDGFB-Targeted Functional MRI Nanoswitch for Activatable T1-T2 Dual-Modal Ultra-Sensitive Diagnosis of Cancer. Journal of Nanobiotechnology, 21, Article No. 9. https://doi.org/10.1186/s12951-023-01769-7 |
| [31] | Leal, M.P., Rivera-Fernández, S., Franco, J.M., et al. (2015) Long-Circulating PEGylated Manganese Ferrite Nanoparticles for MRI-Based Molecular Imaging. Nanoscale, 7, 2050-2059. https://doi.org/10.1039/C4NR05781C |
| [32] | Lee, N. and Hyeon, T. (2012) Designed Synthesis of Uniformly Sized Iron Oxide Nanoparticles for Efficient Magnetic Resonance Imaging Contrast Agents. Chemical Society Reviews, 41, 2575-2589. https://doi.org/10.1039/C1CS15248C |
| [33] | Ma, D., Chen, J., Luo, Y., et al. (2017) Zwitterion-Coated Ultrasmall Iron Oxide Nanoparticles for Enhanced T1-Weighted Magnetic Resonance Imaging Applications. Journal of Materials Chemistry B, 5, 7267-7273. https://doi.org/10.1039/C7TB01588G |
| [34] | Zhao, S., Yu, X., Qian, Y., et al. (2020) Multifunctional Magnetic Iron Oxide Nanoparticles: An Advanced Platform for Cancer Theranostics. Theranostics, 10, 6278-6309. https://doi.org/10.7150/thno.42564 |
| [35] | Kim, B.H., Lee, N., Kim, H., et al. (2011) Large-Scale Synthesis of Uniform and Extremely Small-Sized Iron Oxide Nanoparticles for High-Resolution T1 Magnetic Resonance Imaging Contrast Agents. Journal of the American Chemical Society, 133, 12624-12631. https://doi.org/10.1021/ja203340u |
| [36] | Lu, Y., Xu, Y.-J., Zhang, G.-B., et al. (2017) Iron Oxide Nanoclusters for T1 Magnetic Resonance Imaging of Non-Human Primates. Nature Biomedical Engineering, 1, 637-643. https://doi.org/10.1038/s41551-017-0116-7 |
| [37] | Sherwood, J., Rich, M., Lovas, K., et al. (2017) T1-Enhanced MRI-Visible Nanoclusters for Imaging-Guided Drug Delivery. Nanoscale, 9, 11785-11792. https://doi.org/10.1039/C7NR04181K |
| [38] | Stratton, M.R., Campbell, P.J. and Futreal, P.A. (2009) The Cancer Genome. Nature, 458, 719-724. https://doi.org/10.1038/nature07943 |
| [39] | Green, E.D., Guyer, M.S., Green, E.D., et al. (2011) Charting a Course for Genomic Medicine from Base Pairs to Bedside. Nature, 470, 204-213. https://doi.org/10.1038/nature09764 |
| [40] | Zhu, X., Li, J., Peng, P., et al. (2019) Quantitative Drug Release Monitoring in Tumors of Living Subjects by Magnetic Particle Imaging Nanocomposite. Nano Letters, 19, 6725-6733. https://doi.org/10.1021/acs.nanolett.9b01202 |
| [41] | Wang, C., Wen, H., Guo, H., et al. (2020) A Novel High Doxorubicin-Loaded Fe3O4@Void@ZnO Nanocomposite: PH-Controlled Drug Release and Targeted Antitumor Activity. Journal of Materials Science, 55, 16718-16729. https://doi.org/10.1007/s10853-020-05184-3 |
| [42] | Fang, R.H., Kroll, A.V., Gao, W., et al. (2018) Cell Membrane Coating Nanotechnology. Advanced Materials, 30, Article Id: 1706759. https://doi.org/10.1002/adma.201706759 |
| [43] | Kumar, C.S.S.R. and Mohammad, F. (2011) Magnetic Nanomaterials for Hyperthermia-Based Therapy and Controlled Drug Delivery. Advanced Drug Delivery Reviews, 63, 789-808. https://doi.org/10.1016/j.addr.2011.03.008 |
| [44] | Haemmerich, D. and Laeseke, P.F. (2005) Thermal Tumour Ablation: Devices, Clinical Applications and Future Directions. International Journal of Hyperthermia, 21, 755-760. https://doi.org/10.1080/02656730500226423 |
| [45] | Chu, K.F. and Dupuy, D.E. (2014) Thermal Ablation of Tumours: Biological Mechanisms and Advances in Therapy. Nature Reviews Cancer, 14, 199-208. https://doi.org/10.1038/nrc3672 |
| [46] | Krawczyk, P.M., Eppink, B., Essers, J., et al. (2011) Mild Hyperthermia Inhibits Homologous Recombination, Induces BRCA2 Degradation, and Sensitizes Cancer Cells to Poly (ADP-Ribose) Polymerase-1 Inhibition. Proceedings of the National Academy of Sciences, 108, 9851-9856. https://doi.org/10.1073/pnas.1101053108 |
| [47] | Liu, X., Zhang, Y., Wang, Y., et al. (2020) Comprehensive Understanding of Magnetic Hyperthermia for Improving Antitumor Therapeutic Efficacy. Theranostics, 10, 3793-3815. https://doi.org/10.7150/thno.40805 |
| [48] | Yang, Y., Liu, X., Lv, Y., et al. (2014) Orientation Mediated Enhancement on Magnetic Hyperthermia of Fe3O4 Nanodisc. Advanced Functional Materials, 25, 812-820. https://doi.org/10.1002/adfm.201402764 |
| [49] | Hayashi, K., Nakamura, M., Sakamoto, W., et al. (2013) Superparamagnetic Nanoparticle Clusters for Cancer Theranostics Combining Magnetic Resonance Imaging and Hyperthermia Treatment. Theranostics, 3, 366-376. https://doi.org/10.7150/thno.5860 |
