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脓毒症急性肾损伤的生物标记物研究进展
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Abstract:
脓毒症(sepsis)是由感染引起的全身炎症反应综合征，可导致危及生命的器官功能障碍。脓毒症急性肾损伤(SA-AKI)是危重患者的常见并发症，发病率和死亡率居高不下，早期诊断SA-AKI对临床医师指导治疗和避免肾脏进一步损害至关重要。但至今SA-AKI的早期诊断仍存在许多不足，如何早发现早诊治一直是学术界研究的热点。近年来，随着对SA-AKI病理生理机制的深入研究，一些新兴的潜在生物标记物被发现。本篇综述旨在结合近年来学术界研究新进展对SA-AKI的生物标记物进行总结归纳。
Sepsis is a systemic inflammatory response syndrome caused by infection, which can lead to life-threatening organ dysfunction. Sepsis-induced acute kidney injury (SA-AKI) is a common complication in critically ill patients with high morbidity and mortality. Early diagnosis of SA-AKI is essential for clinicians to guide treatment and avoid further kidney damage. However, there are still many deficiencies in the early diagnosis of SA-AKI. How to detect and diagnose SA-AKI as early as possible has always been a hot topic in academic research. In recent years, with the in-depth study of the pathophysiological mechanism of SA-AKI, some emerging potential biomarkers have been discovered. This review aims to summarize the biomarkers of SA-AKI based on the new progress of academic research in recent years.
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