|
|
脂代谢紊乱在儿童呼吸道合胞病毒感染所致气道炎症中的研究进展
|
Abstract:
呼吸道合胞病毒是世界范围内引起5岁以下儿童急性下呼吸道感染最重要的病毒病原体。生命早期重症RSV感染与后期反复喘息、肺功能异常以及哮喘的发生密切相关，但机制并不清楚。已有研究显示RSV感染引起脂质代谢紊乱可能参与气道炎症，进而影响喘息的发生或加重疾病严重程度。基于此，本文对RSV感染后脂代谢与气道炎症的关系进行综述。
Respiratory syncytial virus (RSV) is the predominant viral pathogen responsible for acute lower respiratory tract infections in children under the age of five globally. Severe RSV infections in early childhood are closely linked to subsequent recurrent wheezing, lung function abnormalities, and the development of asthma, although the precise mechanisms remain incompletely understood. Existing studies suggest that lipid metabolism disorders triggered by RSV infection might contribute to airway inflammation, potentially influencing the onset of wheezing or exacerbating disease severity. Therefore, this article examines the correlation between lipid metabolism and airway inflammation following RSV infection.
| [1] | Hu, M., Bogoyevitch, M.A. and Jans, D.A. (2020) Impact of Respiratory Syncytial Virus Infection on Host Functions: Implications for Antiviral Strategies. Physiological Reviews, 100, 1527-1594. https://doi.org/10.1152/physrev.00030.2019 |
| [2] | Li, Y., Wang, X., Blau, D.M., et al. (2022) Global, Regional, and National Disease Burden Estimates of Acute Lower Respiratory Infections Due to Respiratory Syncytial Virus in Children Younger than 5 Years in 2019: A Systematic Analysis. The Lancet, 399, 2047-2064. https://doi.org/10.1016/S0140-6736(22)00478-0 |
| [3] | Mohapatra, S.S. and Boyapalle, S. (2008) Epidemiologic, Experimental, and Clinical Links between Respiratory Syncytial Virus Infection and Asthma. Clinical Microbiology Reviews, 21, 495-504. https://doi.org/10.1128/CMR.00054-07 |
| [4] | 朱丽丽, 李昌崇. 毛细支气管炎演变为哮喘的相关因素研究[J]. 国际儿科学杂志, 2012, 39(3): 298-300, 303. |
| [5] | Lin, L., An, L., Chen, H., et al. (2021) Integrated Network Pharmacology and Lipidomics to Reveal The Inhibitory Effect of Qingfei Oral Liquid on Excessive Autophagy in RSV-Induced Lung Inflammation. Frontiers in Pharmacology, 12, Article ID: 777689. https://doi.org/10.3389/fphar.2021.777689 |
| [6] | 马铭欣. 呼吸道合胞病毒感染的代谢组学研究进展[J]. 国际儿科学杂志, 2018, 45(5): 349-351. |
| [7] | Asai, A., Okajima, F., Nakajima, Y., et al. (2011) Involvement of Rac GTPase Activation in Phosphatidylcholine Hydroperoxide-Induced THP-1 Cell Adhesion to ICAM-1. Biochemical and Biophysical Research Communications, 406, 273-277. https://doi.org/10.1016/j.bbrc.2011.02.032 |
| [8] | 金晓盛, 吴厉锋, 钱小英, 等. 血脂在下呼吸道感染患者中的临床意义[J]. 温州医学院学报, 2013, 43(9): 607-609. |
| [9] | Fujiogi, M., Camargo, C.A., Raita, Y., et al. (2020) Respiratory Viruses Are Associated with Serum Metabolome among Infants Hospitalized for Bronchiolitis: A Multicenter Study. Pediatric Allergy and Immunology, 31, 755-766. https://doi.org/10.1111/pai.13296 |
| [10] | Chan, R.B., Tanner, L., Wenk, M.R., et al. (2010) Implications for Lipids during Replication of Enveloped Viruses. Chemistry and Physics of Lipids, 163, 449-459. https://doi.org/10.1016/j.chemphyslip.2010.03.002 |
| [11] | Fleming, E.H., Kolokoltsov, A.A., Davey, R.A., et al. (2006) Respiratory Syncytial Virus F Envelope Protein Associates with Lipid Rafts without a Requirement for Other Virus Proteins. Journal of Virology, 80, 12160-12170. https://doi.org/10.1128/JVI.00643-06 |
| [12] | Ohol, Y.M., Wang, Z., Kemble, G., et al. (2015) Direct Inhibition of Cellular Fatty Acid Synthase Impairs Replication of Respiratory Syncytial Virus and Other Respiratory Viruses. PLOS ONE, 10, e0144648. https://doi.org/10.1371/journal.pone.0144648 |
| [13] | Numata, M., Chu, H.W., Dakhama, A., et al. (2010) Pulmonary Surfactant Phosphatidylglycerol Inhibits Respiratory Syncytial Virus-Induced Inflammation and Infection. Proceedings of the National Academy of Sciences, 107, 320-325. https://doi.org/10.1073/pnas.0909361107 |
| [14] | Numata, M, Nagashima, Y., Moore, M.L., et al. (2013) Phosphatidylglycerol Provides Short-Term Rophylaxis against Respiratory Syncytial Virus Infection. Journal of Lipid Research, 54, 2133-2143. https://doi.org/10.1194/jlr.M037077 |
| [15] | Griffiths, P.S., Walton, C., Samsell, L., et al. (2016) Maternal High-Fat Hypercaloric Diet during Pregnancy Results in Persistent Metabolic and Respiratory Abnormalities in Offspring. Pediatric Research, 79, 278-286. https://doi.org/10.1038/pr.2015.226 |
| [16] | Yin, K., Liao, D.F., Tang, C.K., et al. (2010) ATP-Binding Membrane Cassette Transporter A1 (ABCA1): A Possible Link between Inflammation and Reverse Cholesterol Transport. Molecular Medicine, 16, 438-449. https://doi.org/10.2119/molmed.2010.00004 |
| [17] | Stokes, K.L., Currier, M.G., Sakamoto, K., et al. (2013) The Respiratory Syncytial Virus Fusion Protein and Neutrophils Mediate the Airway Mucin Response to Pathogenic Respiratory Syncytial Virus Infection. Journal of Virology, 87, 10070-10082. https://doi.org/10.1128/JVI.01347-13 |
| [18] | Villarreal-Molina, M.T., Aguilar-Salinas, C.A., Rodriguez-Cruz, M., et al. (2007) The ATP-Binding Cassette Transporter A1R230C Variant Affects HDL Cholesterol Levels and BMI in The Mexican Population: Association with Obesity and Obesity-Related Comorbidities. Diabetes, 56, 1881-1887. https://doi.org/10.2337/db06-0905 |
| [19] | Jacobo-Albavera, L., Domínguez-Pérez, M., Medina-Leyte, D.J., et al. (2021) The Role of the ATP Binding Cassette A1 (ABCA1) in Human Disease. International Journal of Molecular Sciences, 22, Article No. 1593. https://doi.org/10.3390/ijms22041593 |
| [20] | Willer, C.J., Schmidt, E.M., Sengupta, S., et al. (2013) Discovery and Refinement of Loci Associated with Lipid Levels. Nature Genetics, 45, 1274-1283. https://doi.org/10.1038/ng.2797 |
| [21] | Dai, P., Tang, Z., Qi, M., et al. (2022) Dispersion and Utilization of Lipid Droplets Mediates Respiratory Syncytial Virus-Induced Airway Hyperresponsiveness. Pediatric Allergy and Immunology, 33, e13651. https://doi.org/10.1111/pai.13651 |
| [22] | Chen, S., Xie, J., Zhao, K., et al. (2020) LPS Aggravates Lung Inflammation Induced by RSV by Promoting the ERK-MMP-12 Signaling Pathway in Mice. Respiratory Research, 21, Article No. 193. https://doi.org/10.1186/s12931-020-01453-6 |
| [23] | Long, X., Xie, J., Zhao, K., et al. (2016) NK Cells Contribute to Persistent Airway Inflammation and AHR during the Later Stage of RSV Infection in Mice. Medical Microbiology and Immunology, 205, 459-470. https://doi.org/10.1007/s00430-016-0459-9 |
| [24] | Reinke, S.N., Gallart-Ayala, H., Gómez, C., et al. (2017) Metabolomics Analysis Identifies Different Metabotypes of Asthma Severity. European Respiratory Journal, 49, Article ID: 1601740. https://doi.org/10.1183/13993003.01740-2016 |
| [25] | Shen, Z.J., Malter, J.S., et al. (2019) Pin1 and the Response to Respiratory Viral Infection and Allergic Stimuli. Critical Reviews？ in Immunology, 39, 135-149. https://doi.org/10.1615/CritRevImmunol.2019031697 |
| [26] | Karta, M.R., Broide, D.H. and Doherty, T.A. (2016) Insights into Group 2 Innate Lymphoid Cells in Human Airway Disease. Current Allergy and Asthma Reports, 16, Article No. 8. https://doi.org/10.1007/s11882-015-0581-6 |
| [27] | Wall, R., Ross, R.P., Fitzgerald, G.F., et al. (2010) Fatty Acids from Fish: The Anti-Inflammatory Potential of Long-Chain Omega-3 Fatty Acids. Nutrition Reviews, 68, 280-289. https://doi.org/10.1111/j.1753-4887.2010.00287.x |
| [28] | Hirata, Y., Inoue, A., Suzuki, S., et al. (2020) Trans-Fatty Acids Facilitate DNA Damage-Induced Apoptosis through the Mitochondrial JNK-Sab-ROS Positive Feedback Loop. Scientific Reports, 10, Article No. 2743. https://doi.org/10.1038/s41598-020-59636-6 |
| [29] | Lu, S., Hartert, T.V., Everard, M.L., et al. (2016) Predictors of Asthma Following Severe Respiratory Syncytial Virus (RSV) Bronchiolitis in Early Childhood. Pediatric Pulmonology, 51, 1382-1392. https://doi.org/10.1002/ppul.23461 |
| [30] | Barochia, A.V., Kaler, M., Cuento, R.A., et al. (2015) Serum Apolipoprotein A-I and Large High-Density Lipoprotein Particles Are Positively Correlated with FEV1 in Atopic Asthma. American Journal of Respiratory and Critical Care Medicine, 191, 990-1000. https://doi.org/10.1164/rccm.201411-1990OC |
| [31] | Kuronuma, K., Mitsuzawa, H., Takeda, K., et al. (2009) Anionic Pulmonary Surfactant Phospholipids Inhibit Inflammatory Responses from Alveolar Macrophages and U937 Cells by Binding the Lipopolysaccharide-Interacting Proteins CD14 and MD-2. Journal of Biological Chemistry, 284, 25488-25500. https://doi.org/10.1074/jbc.M109.040832 |
| [32] | Numata, M., Kandasamy, P., Nagashima, Y., et al. (2012) Phosphatidylglycerol Suppresses Influenza A Virus Infection. American Journal of Respiratory Cell and Molecular Biology, 46, 479-487. https://doi.org/10.1165/rcmb.2011-0194OC |
| [33] | 杜丽娜, 单进军, 谢彤, 等. 呼吸系统疾病相关脂类及脂质组学研究进展[J]. 中国实验方剂学杂志, 2015, 21(4): 219-223. |
| [34] | Medeiros, A., Peres-Buzalaf, C., Fortino Verdan, F., et al. (2012) Prostaglandin E2 and the Suppression of Phagocyte Innate Immune Responses in Different Organs. Mediators of Inflammation, 20, 3275-3268. https://doi.org/10.1155/2012/327568 |
| [35] | Fritscher, L.G., Post, M., Rodrigues, M.T., et al. (2012) Profile of Eicosanoids in Breath Condensate in Asthma and COPD. Journal of Breath Research, 6, 26-31. https://doi.org/10.1088/1752-7155/6/2/026001 |
| [36] | Zaslona, Z., Okunishi, K., Bourdonnay, E., et al. (2014) Prostaglandin E2 Suppresses Allergic Sensitization and Lung Inflammation by Targeting the E Prostanoid 2 Receptor on T Cells. Journal of Allergy and Clinical Immunology, 133, 379-387. https://doi.org/10.1016/j.jaci.2013.07.037 |
| [37] | Liu, T., Zaman, W., Kaphalia, B.S., et al. (2005) RSV-Induced Prostaglandin E2 Production Occurs via CPLA2 Activation: Role in Viral Replication. Virology, 343, 12-24. https://doi.org/10.1016/j.virol.2005.08.012 |
| [38] | Yin, L., Song, Y., Liu, Y., et al. (2019) A Risk Factor for Early Wheezing in Infants: Rapid Weight Gain. BMC Pediatrics, 19, Article No. 352. https://doi.org/10.1186/s12887-019-1720-3 |
| [39] | Antunes, K.H., Stein, R.T., Franceschina, C., et al. (2022) Short-Chain Fatty Acid Acetate Triggers Antiviral Response Mediated by RIG-I in Cells from Infants with Respiratory Syncytial Virus Bronchiolitis. EBioMedicine, 77, Article ID: 103891. https://doi.org/10.1016/j.ebiom.2022.103891 |
| [40] | Hakola, L., Oikarinen, M., Niinist？, S., et al. (2022) Serum 25-Hydroxyvitamin D and Fatty Acids in Relation to the Risk of Microbial Infections in Children: The TRIGR Divia Study. Clinical Nutrition, 41, 2729-2739. https://doi.org/10.1016/j.clnu.2022.10.017 |
| [41] | Hilmarsson, H., Traustason, B.S., et al. (2007) Virucidal Activities of Medium-and Long-Chain Fatty Alcohols and Lipids against Respiratory Syncytial Virus and Parainfluenza Virus Type 2: Comparison at Different pH Levels. Archives of Virology, 152, 2225-2236. https://doi.org/10.1007/s00705-007-1063-5 |
