|
|
老年人群系统性慢性炎症的评估与控制
|
Abstract:
系统性慢性炎症是体内持续存在的低度炎症反应，随着年龄增长机体在分子、细胞、组织水平发生多方面的免疫学改变，使老年人群的系统性炎症水平相对较高，进而引起多种老年性疾病的发生、发展。同时，老年性相关疾病的存在也是促进慢性炎症水平的重要因素。因此，控制系统性慢性炎症是延缓老年性疾病进程的重要途径，也是预防老年慢性疾病的重要策略。老年人群的系统性炎症水平的管理涉及炎症水平的评估与干预方案的设计等诸多方面，本文就相关领域的进展情况进行概述，期待给相关领域的研究者提供便捷的理解，也为后续研究提供一些思路。
Systemic chronic inflammation is a low-grade inflammatory response that persists in the body. The immunological changes occurring in molecular, cellular, and tissue events within the aged population lead to a significantly increased level of systemic inflammation, which contributes to the onset and progression of a variety of senile diseases. The presence of senile diseases itself plays a crucial role in promoting the level of chronic inflammation. Therefore, controlling systemic chronic inflammation is crucial for preventing initiation and slowing progression of the senile diseases. There are multiple factors involved in managing systemic inflammation in older adults, such as assessing inflammation levels and creating intervention programs. This article gives an overview of advancements in related fields, aiming to offer a convenient understanding for researchers and inspire further research.
| [1] | Baechle, J.J., Chen, N., Makhijani, P., et al. (2023) Chronic Inflammation and the Hallmarks of Aging. Molecular Metabolism, 74, Article ID: 101755. https://doi.org/10.1016/j.molmet.2023.101755 |
| [2] | Pacinella, G., Ciaccio, A.M. and Tuttolomondo, A. (2022) Endothelial Dysfunction and Chronic Inflammation: The Cornerstones of Vascular Alterations in Age-Related Diseases. International Journal of Molecular Sciences, 23, Article 15722. https://doi.org/10.3390/ijms232415722 |
| [3] | Chung, H.Y., Kim, D.H., Lee, E.K., et al. (2019) Redefining Chronic Inflammation in Aging and Age-Related Diseases: Proposal of the Senoinflammation Concept. Aging and Disease, 10, 367-382.
https://doi.org/10.14336/AD.2018.0324 |
| [4] | Pourfarzam, M., Zadhoush, F. and Sadeghi, M. (2016) The Difference in Correlation between Insulin Resistance Index and Chronic Inflammation in Type 2 Diabetes with and without Metabolic Syndrome. Advanced Biomedical Research, 5, 153. https://doi.org/10.4103/2277-9175.188489 |
| [5] | Xie, K., Xu, B., Zhang, Y., et al. (2018) A Multi-Method Evaluation of the Effects of Inflammatory Cytokines (IL-1β, IFN-γ, TNF-α) on Pancreatic β-Cells. Journal of Cellular Physiology, 233, 9375-9382.
https://doi.org/10.1002/jcp.26518 |
| [6] | Rehman, K. and Akash, M.S. (2016) Mechanisms of Inflammatory Responses and Development of Insulin Resistance: How Are They Interlinked? Journal of Biomedical Science, 23, Article No. 87.
https://doi.org/10.1186/s12929-016-0303-y |
| [7] | Rajaraman, B., Ramadas, N., Krishnasamy, S., et al. (2019) Hyperglycaemia Cause Vascular Inflammation through Advanced Glycation End Products/Early Growth Response-1 Axis in Gestational Diabetes Mellitus. Molecular and Cellular Biochemistry, 456, 179-190. https://doi.org/10.1007/s11010-019-03503-0 |
| [8] | Purnamasari, D., Khumaedi, A.I., Soeroso, Y., et al. (2019) The Influence of Diabetes and or Periodontitis on Inflammation and Adiponectin Level. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 13, 2176-2182.
https://doi.org/10.1016/j.dsx.2019.05.012 |
| [9] | Fraenkel, P.G. (2017) Anemia of Inflammation: A Review. Medical Clinics of North America, 101, 285-296.
https://doi.org/10.1016/j.mcna.2016.09.005 |
| [10] | Caiado, F., Pietras, E.M. and Manz, M.G. (2021) Inflammation as a Regulator of Hematopoietic Stem Cell Function in Disease, Aging, and Clonal Selection. Journal of Experimental Medicine, 218, e20201541.
https://doi.org/10.1084/jem.20201541 |
| [11] | Yap, J.K.Y., Pickard, B.S., Chan, E.W.L., et al. (2019) The Role of Neuronal NLRP1 Inflammasome in Alzheimer’s Disease: Bringing Neurons into the Neuroinflammation Game. Molecular Neurobiology, 56, 7741-7753.
https://doi.org/10.1007/s12035-019-1638-7 |
| [12] | King, E., O’Brien, J., Donaghy, P., et al. (2019) Inflammation in Mild Cognitive Impairment Due to Parkinson’s Disease, Lewy Body Disease, and Alzheimer’s Disease. International Journal of Geriatric Psychiatry, 34, 1244-1250.
https://doi.org/10.1002/gps.5124 |
| [13] | Fyfe, I. (2019) Inflammatory Pathways Relate to Early Alzheimer Disease Pathology. Nature Reviews Neurology, 15, 493. https://doi.org/10.1038/s41582-019-0242-9 |
| [14] | Chaudhary, R., Prasad, A., Agarwal, V., et al. (2023) Chronic Stress Predisposes to the Aggravation of Inflammation in Autoimmune Diseases with Focus on Rheumatoid Arthritis and Psoriasis. International Immunopharmacology, 125, Article ID: 111046. https://doi.org/10.1016/j.intimp.2023.111046 |
| [15] | Ogawa, Y., Takeuchi, T. and Tsubota, K. (2021) Autoimmune Epithelitis and Chronic Inflammation in Sjogren’s Syndrome-Related Dry Eye Disease. International Journal of Molecular Sciences, 22, Article 11820.
https://doi.org/10.3390/ijms222111820 |
| [16] | Wen, Y., Zhu, Y., Zhang, C., et al. (2022) Chronic Inflammation, Cancer Development and Immunotherapy. Frontiers in Pharmacology, 13, Article 1040163. https://doi.org/10.3389/fphar.2022.1040163 |
| [17] | Nigam, M., Mishra, A.P., Deb, V.K., et al. (2023) Evaluation of the Association of Chronic Inflammation and Cancer: Insights and Implications. Biomedicine & Pharmacotherapy, 164, Article ID: 115015.
https://doi.org/10.1016/j.biopha.2023.115015 |
| [18] | Li, N., Liu, G., Gao, H., et al. (2023) Geriatric Syndromes, Chronic Inflammation, and Advances in the Management of Frailty: A Review with New Insights. BioScience Trends, 17, 262-270. https://doi.org/10.5582/bst.2023.01184 |
| [19] | Yildiz, E., Kuzu, S., Gunebakan, C., et al. (2022) A New Biomarker in Differentiation of Mucosal Chronic Otitis Media from Squamous Chronic Otitis Media: The Systemic Immune-Inflammation Index (SII). Indian Journal of Otolaryngology and Head & Neck Surgery, 74, 476-482. https://doi.org/10.1007/s12070-021-02857-6 |
| [20] | Chung, K.W., Kim, D.H., Jung, H.J., et al. (2023) Chronic Inflammation as an Underlying Mechanism of Ageing and Ageing-Related Diseases. In: Harris, J.R. and Korolchuk, V.I., Eds., Biochemistry and Cell Biology of Ageing: Part IV, Clinical Science, Springer, Cham, 31-44. https://doi.org/10.1007/978-3-031-26576-1_3 |
| [21] | Rasmussen, L.J.H., Petersen, J.E.V. and Eugen-Olsen, J. (2021) Soluble Urokinase Plasminogen Activator Receptor (SuPAR) as a Biomarker of Systemic Chronic Inflammation. Frontiers in Immunology, 12, Article 780641.
https://doi.org/10.3389/fimmu.2021.780641 |
| [22] | Yang, Q., Wang, P., Cai, Y., et al. (2022) Circulating MicroRNA-505 May Serve as a Prognostic Biomarker for Hypertension-Associated Endothelial Dysfunction and Inflammation. Frontiers in Cardiovascular Medicine, 9, Article 834121. https://doi.org/10.3389/fcvm.2022.834121 |
| [23] | Yang, H., Shan, L., Gao, Y.,et al. (2021) MicroRNA-181b Serves as a Circulating Biomarker and Regulates Inflammation in Heart Failure. Disease Markers, 2021, Article ID: 4572282. https://doi.org/10.1155/2021/4572282 |
| [24] | Zhu, M., Zhang, W., Ma, J., et al. (2019) MicroRNA-139-5p Regulates Chronic Inflammation by Suppressing Nuclear Factor-κB Activity to Inhibit Cell Proliferation and Invasion in Colorectal Cancer. Experimental and Therapeutic Medicine, 18, 4049-4057. https://doi.org/10.3892/etm.2019.8032 |
| [25] | Xie, Y., Chu, A., Feng, Y., et al. (2018) MicroRNA-146a: A Comprehensive Indicator of Inflammation and Oxidative Stress Status Induced in the Brain of Chronic T2DM Rats. Frontiers in Pharmacology, 9, Article 478.
https://doi.org/10.3389/fphar.2018.00478 |
| [26] | Fox-Fisher, I., Shemer, R. and Dor, Y. (2023) Epigenetic Liquid Biopsies: A Novel Putative Biomarker in Immunology and Inflammation. Trends in Immunology, 44, 356-364. https://doi.org/10.1016/j.it.2023.03.005 |
| [27] | Ye, W., Wen, C., Zeng, A.,et al. (2023) Increased Levels of Circulating Oxidized Mitochondrial DNA Contribute to Chronic Inflammation in Metabolic Syndrome, and MitoQ-Based Antioxidant Therapy Alleviates This DNA-Induced Inflammation. Molecular and Cellular Endocrinology, 560, Article ID: 111812.
https://doi.org/10.1016/j.mce.2022.111812 |
| [28] | Picca, A., Lezza, A.M.S., Leeuwenburgh, C., et al. (2018) Circulating Mitochondrial DNA at the Crossroads of Mitochondrial Dysfunction and Inflammation during Aging and Muscle Wasting Disorders. Rejuvenation Research, 21, 350-359. https://doi.org/10.1089/rej.2017.1989 |
| [29] | Ramos-Lopez, O., Martinez-Urbistondo, D., Vargas-Nunez, J.A., et al. (2022) The Role of Nutrition on Meta-Inflammation: Insights and Potential Targets in Communicable and Chronic Disease Management. Current Obesity Reports, 11, 305-335.
https://doi.org/10.1007/s13679-022-00490-0 |
| [30] | Streb, A.R., Braga, P.G.S., De Melo, R.F., et al. (2022) Effects of Combined Physical Exercise on Plasma Lipid Variables, Paraoxonase 1 Activity, and Inflammation Parameters in Adults with Obesity: A Randomized Clinical Trial. Journal of Endocrinological Investigation, 45, 1991-1997. https://doi.org/10.1007/s40618-022-01833-3 |
| [31] | Diniz, T.A., Antunes, B.M., Little, J.P., et al. (2022) Exercise Training Protocols to Improve Obesity, Glucose Homeostasis, and Subclinical Inflammation. Methods in Molecular Biology, 2343, 119-145.
https://doi.org/10.1007/978-1-0716-1558-4_7 |
| [32] | Veler, H. (2023) Sleep and Inflammation: Bidirectional Relationship. Sleep Medicine Clinics, 18, 213-218.
https://doi.org/10.1016/j.jsmc.2023.02.003 |
| [33] | Tibbs, T.N., Lopez, L.R. and Arthur, J.C. (2019) The Influence of the Microbiota on Immune Development, Chronic Inflammation, and Cancer in the Context of Aging. Microbial Cell, 6, 324-334.
https://doi.org/10.15698/mic2019.08.685 |
| [34] | Feng, Y.Y., Wang, Z. and Pang, H. (2023) Role of Metformin in Inflammation. Molecular Biology Reports, 50, 789-798. https://doi.org/10.1007/s11033-022-07954-5 |
| [35] | Kannan, S. (2006) Therapeutic Significance of Aspirin Mediated Lipoxin Biosynthesis in Attenuation of Chronic Inflammation. Medical Hypotheses, 66, 442. https://doi.org/10.1016/j.mehy.2005.08.018 |
| [36] | Cho, K.H., Yadav, D., Kim, S.J., et al. (2018) Blood Pressure Lowering Effect of Cuban Policosanol Is Accompanied by Improvement of Hepatic Inflammation, Lipoprotein Profile, and HDL Quality in Spontaneously Hypertensive Rats. Molecules, 23, Article 1080. https://doi.org/10.3390/molecules23051080 |
| [37] | Natsume, M. (2018) Polyphenols: Inflammation. Current Pharmaceutical Design, 24, 191-202.
https://doi.org/10.2174/1381612823666171109104141 |
| [38] | Lu, J., Su, Y., Chen, X., et al. (2019) Rapamycin-Induced Autophagy Attenuates Hormone-Imbalance-Induced Chronic Non-Bacterial Prostatitis in Rats via the Inhibition of NLRP3 Inflammasome-Mediated Inflammation. Molecular Medicine Reports, 19, 221-230. https://doi.org/10.3892/mmr.2018.9683 |
| [39] | Cetin, N., Dasdelen, D., Mogulkoc, R., et al. (2022) Role of Exogenous Putrescine in the Status of Energy, DNA Damage, Inflammation, and Spermidine/Spermine-N(1)-Acetyltransferase in Brain Ischemia-Reperfusion in Rats. Iranian Journal of Basic Medical Sciences, 25, 597-603. |
