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PI3K/AKT/mTOR信号通路在EMT发生发展过程中的研究进展
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Abstract:
上皮细胞–间充质转化(EMT)是指上皮细胞通过特定程序转化为具有间质表型细胞的生物学过程。癌细胞中的部分EMT被认为可以增强其侵袭特性，并促进对抗癌药物的耐药性。磷脂酰肌醇3激酶/蛋白激酶B/哺乳动物雷帕霉素蛋白(PI3K/AKT/mTOR)信号转导通路在恶性肿瘤细胞的增殖、凋亡、侵袭、转移和血管新生方面起着重要作用。在肿瘤的发生发展过程中PI3K/AKT/mTOR信号通路的激活是导致肿瘤细胞生长、发展、增殖、转移特别是EMT失调的重要原因。本文主要针对细胞EMT与PI3K/AKT/mTOR信号转导通路之间的关系进行综述。
Epithelial-mesenchymal transformation (EMT) refers to the biological process by which epithelial cells are transformed into cells with interstitial phenotypes through a specific procedure. Partial EMTs in cancer cells are thought to enhance their aggressive properties and promote resistance to anti-cancer drugs. Phosphatidylinositol 3 kinase/protein kinase B/mammalian rapamycin protein (PI3K/AKT/mTOR) signal transduction pathway plays an important role in the proliferation, apoptosis, invasion, metastasis and angiogenesis of malignant tumor cells. The activation of PI3K/AKT/ mTOR signaling pathway is an important reason for the growth, development, proliferation and metastasis of tumor cells, especially the disorder of EMT. This review focuses on the relationship between cellular EMT and PI3K/AKT/mTOR signal transduction pathways.
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