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瑞马唑仑在麻醉学科的应用进展
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Abstract:
根据“软药”策略而研发的新型超短效水溶性苯二氮卓类镇静药——瑞马唑仑(Remimazolam)，具有起效快、消除快、长时间用无蓄积、基本无注射痛、顺行性遗忘、对肝肾功能依赖小、羧酸代谢物唑仑丙酸(CNS 7054)无药理作用、对呼吸系统和循环系统的影响甚微、有特异拮抗剂——氟马西尼等特点，在麻醉学科应用前景良好，并有望成为静脉镇静药的新选择。本文就瑞马唑仑的研发史、药理特点、麻醉学科应用及使用注意事项等做阐述，旨在为瑞马唑仑在麻醉学科的应用提供参考。
Remimazolam, a new type of ultra-short-acting water-soluble benzodiazepine sedative developed according to the strategy of “soft medicine”, has the characteristics of quick onset, rapid elimination, no accumulation after long-term use, basically no injection pain, anterograde amnesia, little dependence on liver and kidney functions, no pharmacological effect of the carboxylic acid metabolite zolampropionic acid (CNS 7054), little influence on the respiratory system and circulatory system, and a specific antagonist-flumazenil and has a good application prospect in anesthesiology. It is expected to be a new option for intravenous sedatives. This article expounds the research and development history, pharmacological characteristics, application and precautions of remimazolam in anesthesiology, aiming at providing reference for the anesthesiology application of Rimazzolam.
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