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血管内皮生长因子与抑郁障碍相关性研究进展
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Abstract:
抑郁障碍因其高发病率、长病程和高自杀风险而备受关注。近年来大量研究证明血管内皮生长因子(VEGF)在抑郁障碍的发生发展过程中起到一定作用。因此本文就VEGF与抑郁障碍间的关系进行综述，重点探讨了VEGF在神经系统发育、细胞保护、神经元活动调节等方面的作用，以及其在抑郁障碍患者中的表达情况。文章还强调目前仍需要更多深入研究以明确VEGF与抑郁障碍的关系，以探索VEGF在未来抗抑郁治疗策略中的潜在应用。
Depression disorder has garnered significant attention due to its high prevalence, prolonged course, and increased risk of suicide. Recent studies have demonstrated that Vascular Endothelial Growth Factor (VEGF) plays a role in the onset and progression of depression disorders. This article provides a comprehensive review of the relationship between VEGF and depression disorders, focusing on VEGF’s role in neural development, cell protection, and neuron activity regulation, as well as its expression in patients with depression disorders. The article also emphasizes the need for further in-depth research to clarify the relationship between VEGF and depression disorders and to explore the potential application of VEGF in future antidepressant treatment strategies.
| [1] | COVID-19 Mental Disorders Collaborators (2021) Global Prevalence and Burden of Depressive and Anxiety Disorders in 204 Countries and Territories in 2020 Due to the COVID-19 Pandemic. The Lancet (London, England), 398, 1700-1712. |
| [2] | Huang, Y., Wang, Y., Wang, H., et al. (2019) Prevalence of Mental Disorders in China: A Cross-Sectional Epidemiological Study. The Lancet. Psychiatry, 6, 211-224. https://doi.org/10.1016/S2215-0366(18)30511-X |
| [3] | Xin, H., Zhong, C., Nudleman, E. and Ferrara, N. (2016) Evidence for Pro-Angiogenic Functions of VEGF-Ax. Cell, 167, 275-284.E6. https://doi.org/10.1016/j.cell.2016.08.054 |
| [4] | Brockington, A., Lewis, C., Wharton, S. and Shaw, P.J. (2004) Vascular Endothelial Growth Factor and the Nervous System. Neuropathology and Applied Neurobiology, 30, 427-446. https://doi.org/10.1111/j.1365-2990.2004.00600.x |
| [5] | Duric, V. and Duman, R.S. (2013) Depression and Treatment Response: Dynamic Interplay of Signaling Pathways and Altered Neural Processes. Cellular and Molecular Life Sciences: CMLS, 70, 39-53. https://doi.org/10.1007/s00018-012-1020-7 |
| [6] | Zhang, S., Zhang, Y., Zheng, Y., et al. (2023) Dexmedetomidine Attenuates Sleep Deprivation-Induced Inhibition of Hippocampal Neurogenesis via VEGF-VEGFR2 Signaling and Inhibits Neuroinflammation. Biomedicine and Pharmacotherapy, 165, Article ID: 115085. https://doi.org/10.1016/j.biopha.2023.115085 |
| [7] | Belagodu, A.P., Zendeli, L., Slater, B.J. and Galvez, R. (2017) Blocking Elevated VEGF-A Attenuates Non-Vascula-ture Fragile X Syndrome Abnormalities. Developmental Neurobiology, 77, 14-25. https://doi.org/10.1002/dneu.22404 |
| [8] | 仇志富, 颜勇, 吴晓光. PI3K/Akt信号转导通路与神经细胞凋亡研究进展[J]. 中风与神经疾病杂志, 2015, 32(10): 952-953. |
| [9] | 张治楠, 梁丽艳, 连嘉惠, 等. 中枢神经系统PI3K/AKT/MTOR信号通路研究进展[J]. 实用医学杂志, 2020, 36(5): 689-694. |
| [10] | Meissirel, C., Ruiz De Almodovar, C., Knevels, E., et al. (2011) VEGF Modulates NMDA Receptors Activity in Cerebellar Granule Cells through Src-Family Kinases before Synapse Formation. Proceedings of the National Academy of Sciences of the United States of America, 108, 13782-13787. https://doi.org/10.1073/pnas.1100341108 |
| [11] | De Rossi, P., Harde, E., Dupuis, J.P., et al. (2016) A Critical Role for VEGF and VEGFR2 in NMDA Receptor Synaptic Function and Fear-Related Behavior. Molecular Psychiatry, 21, 1768-1780. https://doi.org/10.1038/mp.2015.195 |
| [12] | Xu, J.Y., Zheng, P., Shen, D.H., et al. (2003) Vascular Endothelial Growth Factor Inhibits Outward Delayed-Rectifier Potassium Currents in Acutely Isolated Hippocampal Neurons. Neuroscience, 118, 59-67. https://doi.org/10.1016/S0306-4522(02)00948-X |
| [13] | Ma, Y.Y., Li, K.Y., Wang, J.J., et al. (2009) Vascular Endothelial Growth Factor Acutely Reduces Calcium Influx via Inhibition of the Ca2 Channels in Rat Hippocampal Neurons. Journal of Neuroscience Research, 87, 393-402. https://doi.org/10.1002/jnr.21859 |
| [14] | Sun, G.C. and Ma, Y.Y. (2013) Vascular Endothelial Growth Factor Modulates Voltage-Gated Na( ) Channel Properties and Depresses Action Potential Firing in Cultured Rat Hippocampal Neurons. Biological and Pharmaceutical Bulletin, 36, 548-555. https://doi.org/10.1248/bpb.b12-00841 |
| [15] | Warner-Schmidt, J.L. and Duman, R.S. (2008) VEGF as a Potential Target for Therapeutic Intervention in Depression. Current Opinion in Pharmacology, 8, 14-19. https://doi.org/10.1016/j.coph.2007.10.013 |
| [16] | Shi, Y., Luan, D., Song, R. and Zhang, Z. (2020) Value of Peripheral Neurotrophin Levels for the Diagnosis of Depression and Response to Treatment: A Systematic Review and Meta-Analysis. European Neuropsychopharmacology: The Journal of the European College of Neuropsychopharmacology, 41, 40-51. https://doi.org/10.1016/j.euroneuro.2020.09.633 |
| [17] | Rigal, A., Colle, R., Asmar, K.E., et al. (2020) Lower Plasma Vascular Endothelial Growth Factor A in Major Depressive Disorder Not Normalized after Antidepressant Treatment: A Case Control Study. The Australian and New Zealand Journal of Psychiatry, 54, 402-408. https://doi.org/10.1177/0004867419893433 |
| [18] | 杨杰, 易志凯, 李娜. 中老年首发抑郁症患者血清VEGF、FGF-22水平及相关性[J]. 中国老年学杂志, 2022, 42(23): 5727-5729. |
| [19] | 赵彬, 高志勤, 余海鹰, 等. 抑郁发作未服药患者血清血管内皮细胞生长因子和碱性成纤维细胞生长因子水平及相关因素研究[J]. 中华精神科杂志, 2013, 46(5): 306-307. |
| [20] | Clark-Raymond, A. and Halaris, A. (2013) VEGF and Depression: A Comprehensive Assessment of Clinical Data. Journal of Psychiatric Research, 47, 1080-1087. https://doi.org/10.1016/j.jpsychires.2013.04.008 |
| [21] | 熊丽娟, 高国兰. 妇科恶性肿瘤患者心理因素对血清VEGF水平影响的研究[J]. 中华肿瘤防治杂志, 2010, 17(11): 809-811. |
| [22] | Lutgendorf, S.K., Johnsen, E.L., Cooper, B., et al. (2002) Vascular Endothelial Growth Factor and Social Support in Patients with Ovarian Carcinoma. Cancer, 95, 808-815. https://doi.org/10.1002/cncr.10739 |
| [23] | Howell, K.R., Kutiyanawalla, A. and Pillai, A. (2011) Long-Term Continuous Corticosterone Treatment Decreases VEGF Receptor-2 Expression in Frontal Cortex. PLOS ONE, 6, E20198. https://doi.org/10.1371/journal.pone.0020198 |
| [24] | Maffioletti, E., Gennarelli, M., Magri, C., et al. (2020) Genetic Determinants of Circulating VEGF Levels in Major Depressive Disorder and Electroconvulsive Therapy Response. Drug Development Research, 81, 593-599. https://doi.org/10.1002/ddr.21658 |
| [25] | Elfving, B., Buttensch？n, H.N., Foldager, L., et al. (2014) Depression and BMI Influences the Serum Vascular Endothelial Growth Factor Level. The International Journal of Neuropsychopharmacology, 17, 1409-1417. https://doi.org/10.1017/S1461145714000273 |
| [26] | Han, D., Qiao, Z., Qi, D., et al. (2019) Epistatic Interaction between 5-HT1A and Vascular Endothelial Growth Factor Gene Polymorphisms in the Northern Chinese Han Population with Major Depressive Disorder. Frontiers in Psychiatry, 10, Article No. 218. https://doi.org/10.3389/fpsyt.2019.00218 |
| [27] | Xie, T., Stathopoulou, M.G., De AndréS, F., et al. (2017) VEGF-Related Polymorphisms Identified by GWAS and Risk for Major Depression. Translational Psychiatry, 7, E1055. https://doi.org/10.1038/tp.2017.36 |
| [28] | Hu, Q., Liu, L., Zhou, L., et al. (2020) Effect of Fluoxetine on HIF-1α-Netrin/VEGF Cascade, Angiogenesis and Neuroprotection in a Rat Model of Transient Middle Cerebral Artery Occlusion. Experimental Neurology, 329, Article ID: 113312. https://doi.org/10.1016/j.expneurol.2020.113312 |
| [29] | Chen, F., Danladi, J., Ardalan, M., et al. (2021) The Rat Hippocampal Gliovascular System Following One Week Vortioxetine and Fluoxetine. European Neuropsychopharmacology: The Journal of the European College of Neuropsychopharmacology, 42, 45-56. https://doi.org/10.1016/j.euroneuro.2020.11.008 |
| [30] | 张庆玉, 朱珍珍, 付建飞, 等. 复发性抑郁症患者治疗前后血管内皮生长因子水平变化及与临床疗效的相关性[J]. 浙江医学, 2016, 38(4): 252-255. |
| [31] | 仲照希, 杨鸽, 吕路线. 艾司西酞普兰对首发抑郁患者血清BFGF和VEGF及MMP-9的影响[J]. 医药导报, 2015, 34(10): 1308-1311. |
| [32] | 杨世涛, 祝一虹, 唐文新. 阿立哌唑联合度洛西汀对难治性抑郁的疗效及对血管内皮生长因子的作用研究[J]. 中国临床药理学与治疗学, 2020, 25(8): 937-942. |
| [33] | Chen, F., Danladi, J., Wegener, G., et al. (2020) Sustained Ultrastructural Changes in Rat Hippocampal Formation after Repeated Electroconvulsive Seizures. The International Journal of Neuropsychopharmacology, 23, 446-458. https://doi.org/10.1093/ijnp/pyaa021 |
| [34] | Elfving, B. and Wegener, G. (2012) Electroconvulsive Seizures Stimulate the Vegf Pathway via MTORC1. Synapse (New York, N.Y.), 66, 340-345. https://doi.org/10.1002/syn.21518 |
| [35] | Sorri, A., J？rventausta, K., Kampman, O., et al. (2021) Electroconvulsive Therapy Increases Temporarily Plasma Vascular Endothelial Growth Factor in Patients with Major Depressive Disorder. Brain and Behavior, 11, E02001. https://doi.org/10.1002/brb3.2001 |
| [36] | 龚培贤, 孙涛, 刘金玮, 范正军. 肝细胞癌根治性切除术患者术前血清AFP、VEGF水平及肿瘤组织Ki-67表达水平与早期复发的关系[J]. 山东医药, 2022, 62(15): 28-32. |
| [37] | 于海群, 程锦锦, 袁艳. 老年急性脑梗死患者外周血血管内皮生长因子、正五聚蛋白3、神经元特异性烯醇化酶水平与溶栓疗效的关系研究[J]. 实用医院临床杂志, 2022, 19(4): 85-88. |
| [38] | 张欢, 苏炳新, 徐良成. Hs-CRP联合VEGF-B检测对急性STEMI患者介入术后MACE的预测价值[J]. 中国急救复苏与灾害医学杂志, 2022, 17(7): 939-942. |
