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小而密低密度脂蛋白与心血管疾病的研究进展
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Abstract:
动脉粥样硬化是引起心血管疾病的主要原因，降低低密度脂蛋白是针对动脉粥样硬化疾病的关键治疗之一，其中，小而密低密度脂蛋白(Small Dense Low-Density Lipoprotein, sdLDL)作为心血管疾病的独立危险因素，其水平越高，患心血管疾病的风险越高。这篇综述分析了sdLDL的合成代谢及致动脉粥样硬化机制，sdLDL与心血管相关疾病的联系。同时，本文还介绍了降低sdLDL的措施，包括饮食、锻炼、降脂药物，特别是前蛋白转化酶枯草杆菌蛋白酶-9 (PCSK9)抑制剂等。
Atherosclerosis is the main pathogenesis of cardiovascular disease, and lowering Low-Density Lipoprotein (LDL) is one of the key treatments for atherosclerotic disease, among which Small Dense Low-Density Lipoprotein (sdLDL) is an independent risk factor for cardiovascular disease, with its level elevated, the risk of cardiovascular disease higher. This review analyses the anabolic, atherosclerotic mechanisms of sdLDL, the association between sdLDL and cardiovascular-related diseases. Moreover, we also introduce some sdLDL lowering agents, including diet, exercise, lipid-lowering drugs, especially proprotein convertase subtilisin-9 (PCSK9) inhibitors.
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