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氧化应激与勃起功能障碍
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Abstract:
氧化应激是一种生理和病理状态下细胞内外氧化还原平衡失调的情况，已被证明与多种疾病的发生和发展密切相关。在勃起功能障碍(ED)的研究中，氧化应激也被发现起着重要作用。本文综述了氧化应激与代谢综合症、心血管疾病以及勃起功能障碍的关系，深入探讨了氧化应激对勃起功能的影响机制。研究表明，氧化应激可以导致血管内皮功能损伤、阴茎组织结构和功能异常，从而影响勃起的发生和维持。未来的研究需要进一步明确氧化应激在ED发展中的作用机制，加强其诊断与监测方法，探索针对氧化应激的治疗策略，以期为预防和治疗ED提供更为有效的手段和策略。
Oxidative stress, characterized by an imbalance between the production of reactive oxygen species (ROS) and the antioxidant defense system, is closely associated with various physiological and pathological conditions. In the study of erectile dysfunction (ED), oxidative stress has emerged as a significant contributor. This review explores the relationship between oxidative stress and metabolic syndrome, cardiovascular diseases, and erectile dysfunction, delving into the mechanisms through which oxidative stress impacts erectile function. Research suggests that oxidative stress can induce endothelial dysfunction, structural and functional abnormalities in penile tissues, thereby affecting the occurrence and maintenance of erection. Future investigations should further elucidate the mechanisms by which oxidative stress contributes to ED development, enhance diagnostic and monitoring methods, and explore therapeutic strategies targeting oxidative stress to provide more effective means for the prevention and treatment of ED.
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