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接骨木提取物对骨折愈合的作用及机制研究进展
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Abstract:
骨折在日常生活中越来越常见，骨折不愈合、延迟愈合是骨折常见的并发症，也是骨科疾病的难点，促进骨折愈合是减少骨折不愈合、延迟愈合的关键因素，近年来，随着自然药物在促进伤口愈合和组织再生方面潜力的逐渐显现，接骨木因其丰富的化学成分和多方面的药理活性，成为了骨折愈合研究领域的热点。本综述旨在探讨接骨木的有效化学成分以及在促进骨折愈合方面的作用及其潜在机制。基于目前的科学文献，分析其主要有效成分如黄酮类化合物、环烯醚萜类化合物、木脂素类化合物等在抗炎、促进细胞增殖、改善微循环和抗氧化等方面的作用，探讨接骨木提取物通过多种信号通路促进骨折愈合的机制。
Fractures are becoming increasingly common in daily life, and non union and delayed healing are common complications of fractures and difficulties in orthopedic diseases. Promoting fracture healing is a key factor in reducing non union and delayed healing. In recent years, with the gradual emergence of the potential of natural drugs in promoting wound healing and tissue regeneration, elderberry, due to its rich chemical components and multifaceted pharmacological activities, has become a hot topic in the field of fracture healing research. This review aims to explore the effective chemical components of elderberry and its role and potential mechanisms in promoting fracture healing. Based on current scientific literature, it analyzes the effects of its main active ingredients such as flavonoids, iridoid compounds, lignans, etc. on anti-inflammatory, promoting cell proliferation, improving microcirculation, and antioxidant properties, and explores the mechanism of elderberry extract promoting fracture healing through multiple signaling pathways.
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