|
|
中医防治司美格鲁肽治疗2型糖尿病引起功能性消化不良的研究进展
|
Abstract:
司美格鲁肽作为治疗2型糖尿病的新型药物，在其治疗过程中常引起功能性消化不良。本文通过对司美格鲁肽治疗2型糖尿病引起功能性消化不良的机制探讨，归纳中医防治司美格鲁肽治疗2型糖尿病引起功能性消化不良的研究进展，为司美格鲁肽治疗2型糖尿病提供帮助。
As a new drug for the treatment of type 2 diabetes, Semaglutide often causes functional dyspepsia in the course of its treatment. This paper discusses the mechanism of functional dyspepsia caused by Semaglutide in the treatment of type 2 diabetes mellitus, summarises the research progress of Chinese medicine in the prevention and treatment of functional dyspepsia caused by Semaglutide in the treatment of type 2 diabetes mellitus, and provides help for the treatment of type 2 diabetes mellitus with Semaglutide.
| [1] | Ji, L., Hu, D., Pan, C., Weng, J., Huo, Y., Ma, C., Mu, Y., Hao, C., Ji, Q., Ran, X., Su, B., Zhuo, H., Fox, K.A., Weber, M., Zhang, D., CCMR Advisory Board and CCMR-3B STUDY Investigators (2013) Primacy of the 3B Approach to Control Risk Factors for Cardiovascular Disease in Type 2 Diabetes Patients. The American Journal of Medicine, 126, 925.E11-925.E22. https://doi.org/10.1016/j.amjmed.2013.02.035 |
| [2] | Garber, A.J., Abrahamson, M.J., Barzilay, J.I., Blonde, L., Bloomgarden, Z.T., Bush, M.A., Dagogo-Jack, S., DeFronzo, R.A., Einhorn, D., Fonseca, V.A., Garber, J.R., Garvey, W.T., Grunberger, G., Handelsman, Y., Hirsch, I.B., Jellinger, P.S., McGill, J.B., Mechanick, J.I., Rosenblit, P.D. and Umpierrez, G.E. (2018) Consensus Statement by the American Association of Clinical Endocrinologists and American College of Endocrinology on the Comprehensive Type 2 Diabetes Management Algorithm—2018 Executive Summary. Endocrine Practice, 24, 91-120. https://doi.org/10.4158/CS-2017-0153 |
| [3] | ElSayed, N.A., Aleppo, G., Aroda, V.R., Bannuru, R.R., Brown, F.M., Bruemmer, D., Collins, B.S., Hilliard, M.E., Isaacs, D., Johnson, E.L., Kahan, S., Khunti, K., Leon, J., Lyons, S.K., Perry, ML., Prahalad, P., Pratley, R.E., Seley, J.J., Stanton, R.C., Gabbay, R.A. and on Behalf of the American Diabetes Association (2023) 6. Glycemic Targets: Standards of Care in Diabetes—2023. Diabetes Care, 46, S97-S110. https://doi.org/10.2337/dc23-S006 |
| [4] | Hou, X., Lu, J., Weng, J., Ji, L., Shan, Z., Liu, J., Tian, H., Ji, Q., Zhu, D., Ge, J., Lin, L., Chen, L., Guo, X., Zhao, Z., Li, Q., Zhou, Z., Shan, G., Yang, Z., Yang, W., Jia, W. and China National Diabetes and Metabolic Disorders Study Group (2013) Impact of Waist Circumference and Body Mass Index on Risk of Cardiometabolic Disorder and Cardiovascular Disease in Chinese Adults: A National Diabetes and Metabolic Disorders Survey. PLOS ONE, 8, e57319. https://doi.org/10.1371/journal.pone.0057319 |
| [5] | Jia, W., Weng, J., Zhu, D., et al. (2019) Standards of Medical Care for Type 2 Diabetes in China 2019. Diabetes/ Metabolism Research and Reviews, 35, e3158. https://doi.org/10.1002/dmrr.3158 |
| [6] | Look AHEAD Research Group and Wing, R.R. (2010) Long-Term Effects of a Lifestyle Intervention on Weight and Cardiovascular Risk Factors in Individuals with Type 2 Diabetes Mellitus: Four-Year Results of the Look ahead Trial. Archives of Internal Medicine, 170, 1566-1575. https://doi.org/10.1001/archinternmed.2010.334 |
| [7] | Lau, J., Bloch, P., Sch？ffer, L., Pettersson, I., Spetzler, J., Kofoed, J., Madsen, K., Knudsen, L.B., McGuire, J., Steensgaard, D.B., Strauss, H.M., Gram, D.X., Knudsen, S.M., Nielsen, F.S., Thygesen, P., Reedtz-Runge, S. and Kruse, T. (2015) Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide. Journal of Medicinal Chemistry, 58, 7370-7380. https://doi.org/10.1021/acs.jmedchem.5b00726 |
| [8] | Sorli, C., Harashima, S.I., Tsoukas, G.M., et al. (2017) Efficacy and Safety of Onceweekly Semaglutide Monotherapy versus Placebo in Patients with Type 2 Diabetes (SUSTAIN 1): A Double-Blind, Randomised, Placebocontrolled, Parallel-Group, Multinational, Multicentre Phase 3a Trial. The Lancet Diabetes and Endocrinology, 5, 251-260. https://doi.org/10.1016/S2213-8587(17)30013-X |
| [9] | Seino, Y., Terauchi, Y., Osonoi, T., et al. (2018) Safety and Efficacy of Semaglutide Once Weekly vs Sitagliptin Once Daily, Both as Monotherapy in Japanese People with Type 2 Diabetes. Diabetes, Obesity and Metabolism, 20, 378-388. https://doi.org/10.1111/dom.13082 |
| [10] | Marso, S.P., Bain, S.C., Consoli, A., et al. (2016) Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. The New England Journal of Medicine, 375, 1834-1844. https://doi.org/10.1056/NEJMoa1607141 |
| [11] | Nielsen, L.L., Young, A.A. and Parkes, D.G. (2004) Pharmacology of Exenatide (Synthetic Exendin-4): A Potential Therapeutic for Improved Glycemic Control of Type 2 Diabetes. Regulatory Peptides, 117, 77-88. https://doi.org/10.1016/j.regpep.2003.10.028 |
| [12] | Thazhath, S.S., Marathe, C.S., Wu, T., Chang, J., Khoo, J., Kuo, P., Checklin, H.L., Bound, M.J., Rigda, R.S., Crouch, B., Jones, K.L., Horowitz, M. and Rayner, C.K. (2016) The Glucagon-Like Peptide 1 Receptor Agonist Exenatide Inhibits Small Intestinal Motility, Flow, Transit, and Absorption of Glucose in Healthy Subjects and Patients with Type 2 Diabetes: A Randomized Controlled Trial. Diabetes, 65, 269-275. https://doi.org/10.2337/db15-0893 |
| [13] | Wauters, L., Talley, N.J., Walker, M.M., Tack, J. and Vanuytsel, T. (2020) Novel Concepts in Thepathophysiology and Treatment of Functional Dyspepsia. Gut, 69, 591-600. https://doi.org/10.1136/gutjnl-2019-318536 |
| [14] | 龚自坤, 郑秋惠, 梅凯雁. 肿瘤化疗后恶心呕吐的中医治疗研究进展[J]. 亚太传统医药, 2020, 16(9): 200-205. |
| [15] | 杨天华. 功能性消化不良的诊疗策略[J]. 中国实用医药, 2010, 5(10): 59-60. https://doi.org/10.14163/j.cnki.11-5547/r.2010.10.115 |
| [16] | Wood, J.D., Alpers, D.H. and Andrews, P.L. (1999) Fundamentals of Neurogastroenterology. Gut, 45, II6-II16. https://doi.org/10.1136/gut.45.2008.ii6 |
| [17] | Walker, M.M., Potter, M.D. and Talley, N.J. (2019) Tangible Pathologies in Functional Dyspepsia. Best Practice & Research Clinical Gastroenterology, 40-41, Article ID: 101650. https://doi.org/10.1016/j.bpg.2019.101650 |
| [18] | 张声生, 钦丹萍, 周强, 纪云西, 李军祥, 唐旭东, 卢小芳, 赵鲁卿, 孟梦, 温艳东, 王凤云, 吕林. 消化系统常见病功能性消化不良中医诊疗指南(基层医生版) [J]. 中华中医药杂志, 2019, 34(8): 3619-3625. |
| [19] | 曾光, 陈国忠, 莫喜晶, 等. 香砂六君子汤治疗功能性消化不良的Meta分析[J]. 辽宁中医药大学学报, 2013, 15(5): 123-125. |
| [20] | 吴界呈. 逍遥散对功能性消化不良的临床疗效观察[D]: [硕士学位论文]. 北京: 北京中医药大学, 2014. |
| [21] | 林立志, 郑涛, 冯志刚. 当归活血汤联合针刺治疗气虚血瘀型糖尿病周围神经病变疗效观察[J]. 湖北中医药大学学报, 2023, 25(6): 74-76. |
| [22] | 陈金香. 运用活血化瘀药治疗难治性溃疡机理探析[J]. 实用中医内科杂志, 2002, 16(3): 123-124. |
| [23] | 黄凤文. 通络法与化瘀法关系临床浅谈[J]. 黑龙江中医药, 2007, 36(2): 2. |
| [24] | 沈祥春, 张贵林, 任光友. 左金丸总生物碱对胃肠功能的影响[J]. 中药药理与临床, 2006, 22(6): 34-36. |
| [25] | 郑金粟, 赵鲁卿, 周强, 等. 张声生运用祛湿药治疗脾胃病的经验[J]. 中华中医药杂志, 2019, 34(6): 2505-2507. |
| [26] | 温佩仪, 赖勇. 加味连朴饮治疗功能性消化不良餐后不适综合征(脾胃湿热证)临床观察[J]. 广西中医药, 2014, 37(2): 39-41. |
| [27] | 黄清, 曹桂芳. 金胃泰胶囊治疗脾胃湿热型胃脘痛的临床研究[J]. 云南中医中药杂志, 2018, 39(6): 94-95. https://doi.org/10.16254/j.cnki.53-1120/r.2018.06.040 |
| [28] | 王蕾, 李廷谦, 张瑞明, 等. 达立通颗粒治疗痞满证(功能性消化不良)的随机对照双盲试验[J]. 中国循证医学杂志, 2004, 4(4): 239-243, 266. |
| [29] | 苏青, 涂蕾, 贾小红, 等. 气滞胃痛颗粒治疗功能性消化不良患者随机、双盲、安慰剂对照临床研究[J]. 临床消化病杂志, 2016, 28(4): 216-219. |
| [30] | 许翠萍, 徐大毅, 寇秋爱, 等. 枳术宽中胶囊治疗功能性消化不良403例的Ⅱ期临床试验[J]. 中国新药与临床杂志, 2004, 23(8): 493-497. |
| [31] | 张鑫. 香砂养胃丸与温胃舒胶囊辨证论治慢性胃炎的疗效对比[J]. 中国药业, 2014, 23(20): 109-110. |
| [32] | 夏文阳. 荆花胃康胶丸治疗寒热错杂型功能性消化不良疗效观察[J]. 湖北中医杂志, 2017, 39(11): 23-24. |
| [33] | 冷雪峰. 针刺治疗功能性消化不良的系统评价[D]: [硕士学位论文]. 沈阳: 辽宁中医药大学, 2013. |
| [34] | 卢焕章, 李嘉怡, 吴瑞兰, 等. 揿针埋针联合中药热奄包对肠癌围化疗期胃肠道反应及生活质量的影响[J]. 现代中西医结合杂志, 2022, 31(13): 1828-1832. |
| [35] | 张禹, 孙申田. 头针联合经颅重复针刺法治疗肝郁脾虚型功能性消化不良的临床观察[J]. 中国中医药科技, 2021, 28(2): 325-328. |
| [36] | 李学军, 江应露, 刘礼梅, 陈亮亮, 金月萍, 吴婧. 脾胃培源散穴位外敷治疗脾胃虚寒型功能性消化不良疗效及对血清MTL的影响[J]. 国医论坛, 2016, 31(5): 30-33. |
| [37] | Hong, S.H., Ding, S.S., Wu, F., et al. (2017) Efficacy and Safety of Manual Acupuncture Manipulations with Different Frequencies on Epigastric Pain Syndrome (EPS) in Functional Dyspepsia (FD) Patients: Study Protocol for a Randomized Controlled Trial. Trials, 18, Article No. 102. https://doi.org/10.1186/s13063-017-1845-3 |
| [38] | 曾秀娣. 中药热敷治疗脑卒中偏瘫并发膝关节骨性关节炎疼痛的疗效观察[J]. 中国实用医药, 2020, 15(20): 173-175. https://doi.org/10.14163/j.cnki.11-5547/r.2020.20.074 |
| [39] | 何愉涛. “运腹通经”推拿法治疗功能性消化不良的临床研究[D]: [硕士学位论文]. 长春: 长春中医药大学, 2023. |
| [40] | 潘燕, 李杰, 徐丽萍, 等. 引火归元灸治疗功能性消化不良脾肾阳虚型临床观察[J]. 实用中医药杂志, 2023, 39(7): 1414-1416. |
| [41] | 苏清敏, 苏凌瑞. 伊托必利联合穴位注射治疗功能性消化不良重叠便秘型肠易激综合征的临床观察[J]. 医学综述, 2015, 21(23): 4411-4413. |
