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心肌纤维化中人参皂苷Rg1和分化抑制因子-2的作用
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Abstract:
心血管疾病是影响全球预期寿命的重要因素，心肌纤维化是心血管疾病终末期的基础病理表现，也是心血管疾病的加重因素。中医药改善心肌纤维化效果显著，人参皂苷Rg1可通过多种机制减轻心肌纤维化。分化抑制因子2 (ID2)是多脏器纤维化的负性调控因子，其表达增高对肝、肺、肾小管等多组织纤维化起减轻作用。本文对人参皂苷Rg1改善心肌纤维化和Id2与心肌纤维化关系进行综述，为基于Id2靶点的中药干预提供思路。
Cardiovascular disease is an important factor affecting global life expectancy, and myocardial fibrosis is the underlying pathological manifestation of end-stage cardiovascular disease and an aggravating factor of cardiovascular disease. Traditional Chinese medicine is effective in improving myocardial fibrosis, and ginsenoside Rg1 can reduce myocardial fibrosis through multiple mechanisms. Inhibitor of differentiation 2 (ID2) is a negative regulator of multi-organ fibrosis, and its increased expression plays an attenuating role in multi-tissue fibrosis such as liver, lung, and renal tubule. In this paper, ginsenoside Rg1 ameliorates myocardial fibrosis and the relationship between Id2 and myocardial fibrosis are reviewed to provide ideas for traditional Chinese medicine interventions based on Id2 targets.
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