抗心磷脂抗体在卵巢储备功能减退患者中的检测价值
Detection Value of Anticardiolipin Antibodies in Patients with Reduced Ovarian Reserve

目的：本研究旨在考察抗心磷脂抗体(aCL)与卵巢储备功能减退(DOR)患者表达水平间的相关性分析。方法：2021年12月~2023年12月期间于新疆维吾尔自治区人民医院生殖医学科就诊的育龄期女性作为研究对象。根据纳入排除标准分为病例组和对照组，收集两组患者一般信息：年龄，身高，体重，体重指数(BMI)，稽留流产史、自然流产史、晚期流产史、生化妊娠史，抽取两组患者血液，检查AMH、性激素全套水平、aCL，比较两组患者间aCL水平及是否存在差异。统计学分析：符合正态分布的计量资料以均数 ± 标准差()描述，两组间比较采用独立样本t检验，非正态分布的计量资料以中位数和四分位间距[M(Q1,Q3)]描述，两组间比较采用Mann-Whitney U秩和检验，计数资料以例数和构成比N(%)描述，两组间比较采用卡方检验。使用SPSS 26.0软件进行统计分析，使用Graphpad Prim8.0绘图。采用双侧检验，当P < 0.05时有统计学意义。结果：1)对照组和病例组两组患者间年龄(P = 0.488)、不孕年限(P = 0.077)、BMI (P = 0.111)、流产类型(P = 0.571)没有差异。2) 对照组有抗心磷脂抗体阳性的5例(6.85%)，病例组有抗心磷脂抗体阳性15例(17.86%)，两组患者间抗心磷脂抗体阳性率(χ² = 4.257, P = 0.039)差异有统计学意义。结论：对育龄期DOR患者推荐进行血清aCL的筛查，及时发现DOR患者潜在病因，为DOR患者针对病因进行临床干预提供参考。
Objective: This study aims to examine the correlation between anticardiolipin antibody (aCL) and expression levels in patients with ovarian reserve decline (DOR); Methods: General information was collected from both groups: age, height, weight, body mass index (BMI), history of abortion, history of spontaneous abortion, late abortion, and history of biochemical pregnancy. Blood was drawn from the two groups to check AMH, sex hormone set levels, aCL, and compare the aCL levels and differences between the two groups. Statistical analysis: measurement data with normal distribution in mean ± standard deviation (), comparison between two groups using independent sample t-test, non-normal distribution measurement data in the median and interquartile spacing [M (Q1, Q3)], comparison between the two groups using Mann-Whitney U rank sum test, count data in the number and composition ratio N (%), and comparison between two groups using chi-square test. Statistical analysis was performed using SPSS 26.0 software and plot using Graphpad Prim8.0. A two-sided test was used with statistical significance when P < 0.05. Results: 1) There was no difference in age (P = 0.488), in years of infertility (P = 0.077), BMI (P = 0.111), and abortion type (P = 0.571) between the control and case groups. 2) In the control group, 5 (6.85%) were positive for anti-cardiolipin antibody and 15 (17.86%) were positive in the case group. There was a statistically significant difference in the positive rate (χ² = 4.257, P = 0.039) between the two groups. Conclusion: It is recommended to screen serum aCL for DOR patients of childbearing age, so as to timely detect the potential etiology of DOR patients, and to provide reference for clinical