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靶向铁死亡防治重大疾病研究进展
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Abstract:
铁死亡(Ferroptosis)是一种铁依赖的细胞死亡途径，其特征在于引起脂质过氧化物的积聚，同时过量Fe2 通过芬顿反应(Fenton reaction)氧化细胞膜上不饱和脂肪酸(polyunsaturated fatty acids, PUFAs)，从而引发铁死亡。已经有报道铁死亡在包括肿瘤、心血管疾病、肝脏疾病等重大疾病中发挥重要的防治作用。本综述总结了铁死亡在肿瘤、心血管疾病、肝脏疾病以及其他疾病中的最新研究进展，并探讨了铁死亡在防治重大疾病中的前景，为防治重大疾病提供新的策略。
Ferroptosis is an iron-dependent cell death mode, characterized by the accumulation of lipid peroxides and the oxidation of polyunsaturated fatty acids (PUFAs) on the cell membrane by excessive Fe2 through the Fenton reaction, leading to ferroptosis. It has been reported that ferroptosis plays an important role in the prevention and treatment of major diseases, including tumors, cardiovascular diseases, liver diseases and so on. This review summarizes the latest research progress of ferroptosis in tumors, cardiovascular diseases, liver diseases and other diseases, and discusses the prospect of ferroptosis in the prevention and treatment of major diseases, so as to provide new strategies for the prevention and treatment of major diseases.
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