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无痛人流镇静镇痛策略及进展
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Abstract:
我国无痛人流手术麻醉方案现多为静脉全身麻醉,多基于以丙泊酚为代表的镇静药复合以阿片类为代表的镇痛药使用,相关麻醉方案各有其优缺点。随着近年来新型麻醉镇静镇痛药物的上市,如瑞马唑仑、艾司氯胺酮、环泊酚、阿芬太尼等,为无痛人流麻醉提供了更多选择。本文对近年来无痛人流麻醉用药相关研究进行综述,重点关注近年来上市的新型药物在无痛人流中的应用,为无痛人流麻醉用药提供参考,并对未来可能的临床应用进行展望。
The anesthesia scheme for painless abortion surgery in my country is mostly intravenous general anesthesia, which is mostly based on the use of sedatives represented by propofol combined with analgesics represented by opioids. Each relevant anesthesia scheme has its own advantages and disadvantages. With the launch of new anesthetic, sedative and analgesic drugs in recent years, such as remimazolam, esketamine, cyclopofol, alfentanil, etc., more options are provided for painless abortion anesthesia. This article reviews the research on the use of anesthetic drugs for painless abortion in recent years, focusing on the application of new drugs that have been launched in recent years in painless abortion, providing a reference for the use of anesthetic drugs for painless abortion, and looking forward to possible future clinical applications.
[1] | 邓世芸, 刘丹彦. 丙泊酚复合不同药物用于无痛人流的临床现状[J]. 现代临床医学, 2021, 47(2): 135-138. |
[2] | 吴熠. 无痛人流术中使用静脉复合麻醉的效果观察[J]. 名医, 2020(8): 301-302. |
[3] | Guan, X., Jiao, Z., Gong, X., et al. (2021) Efficacy of Pre-Treatment with Remimazolam on Prevention of Propofol-Induced Injection Pain in Patients Undergoing Abortion or Curettage: A Prospective, Double-Blinded, Randomized and Placebo-Controlled Clinical Trial. Drug Design, Development and Therapy, 15, 4551-4558. https://doi.org/10.2147/DDDT.S334100 |
[4] | 张相祖. 丙泊酚用于1000例无痛人工流产的不良反应分析[J]. 中国新药杂志, 2003, 12(2): 140-141. |
[5] | Valk, B.I. and Struys, M.M.R.F. (2021) Etomidate and Its Analogs: A Review of Pharmacokinetics and Pharmacodynamics. Clinical Pharmacokinetics, 60, 1253-1269. https://doi.org/10.1007/s40262-021-01038-6 |
[6] | Birgenheier, N.M., Stuart, A.R. and Egan, T.D. (2020) Soft Drugs in Anesthesia: Remifentanil as Prototype to Modern Anesthetic Drug Development. Current Opinion in Anaesthesiology, 33, 499-505. https://doi.org/10.1097/ACO.0000000000000879 |
[7] | Sneyd, J.R. and Rigby-Jones, A.E. (2020) Remimazolam for Anaesthesia or Sedation. Current Opinion in Anaesthesiology, 33, 506-511. https://doi.org/10.1097/ACO.0000000000000877 |
[8] | Kreutzwiser, D. and Tawfic, Q.A. (2019) Expanding Role of NMDA Receptor Antagonists in the Management of Pain. CNS Drugs, 33, 347-374. https://doi.org/10.1007/s40263-019-00618-2 |
[9] | Peltoniemi, M.A., Hagelberg, N.M., Olkkola, K.T., et al. (2016) Ketamine: A Review of Clinical Pharmacokinetics and Pharmacodynamics in Anesthesia and Pain Therapy. Clinical Pharmacokinetics, 55, 1059-1077. https://doi.org/10.1007/s40262-016-0383-6 |
[10] | Zhou, J.Y., Hamilton, P., Macres, S., et al. (2020) Update on Ketamine. Advances in Anesthesia, 38, 97-113. https://doi.org/10.1016/j.aan.2020.07.005 |
[11] | Darnobid, J.A. (2015) The Pharmacology of Total Intravenous Anesthesia. International Anesthesiology Clinics, 53, 13-27. https://doi.org/10.1097/AIA.0000000000000057 |
[12] | Aroni, F., Iacovidou, N., Dontas, I., et al. (2009) Pharmacological Aspects and Potential New Clinical Applications of Ketamine: Reevaluation of an Old Drug. The Journal of Clinical Pharmacology, 49, 957-964. https://doi.org/10.1177/0091270009337941 |
[13] | Argiriadou, H., Himmelseher, S., Papagiannopoulou, P., et al. (2004) Improvement of Pain Treatment after Major Abdominal Surgery by Intravenous S( )-Ketamine. Anesthesia & Analgesia, 98, 1413-1418. https://doi.org/10.1213/01.ANE.0000111204.31815.2D |
[14] | Mihaljevi?, S., Pavlovi?, M., Reiner, K., et al. (2020) Therapeutic Mechanisms of Ketamine. Psychiatria Danubin, 32, 325-333. https://doi.org/10.31219/osf.io/5xryf |
[15] | Zhong, J., Zhang, J., Fan, Y., et al. (2023) Efficacy and Safety of Ciprofol for Procedural Sedation and Anesthesia in Non-Operating Room Settings. Journal of Clinical Anesthesia, 85, Article 111047. https://doi.org/10.1016/j.jclinane.2022.111047 |
[16] | Lu, M., Liu, J., Wu, X., et al. (2023) Ciprofol: A Novel Alternative to Propofol in Clinical Intravenous Anesthesia? BioMed Research International, 2023, Article ID: 7443226. https://doi.org/10.1155/2023/7443226 |
[17] | 温莉. 丙泊酚与依托咪酯无痛人流患者麻醉苏醒后的心理状态与药物安全性比较[J]. 临床医药文献电子杂志, 2017, 4(94): 18543. |
[18] | 肖倩. 苯磺酸瑞马唑仑与丙泊酚在无痛人流麻醉中的应用研究[J]. 蛇志, 2021, 33(3): 298-300. |
[19] | 吴晓雯, 胡念慈, 刘卫华, 等. 人流术中甲苯磺酸瑞马唑仑联合芬太尼半数有效剂量的测定[J]. 中国现代医药杂志, 2022, 24(3): 43-46. |
[20] | 黎晖. 丙泊酚复合芬太尼、舒芬太尼、瑞芬太尼用于无痛人流术的有效性及安全性的观察[J]. 现代医学与健康研究电子杂志, 2019, 3(21): 103-104. |
[21] | 张慧娟. 丙泊酚复合不同剂量舒芬太尼用于无痛人流术的临床观察[J]. 北方药学, 2016, 13(12): 194-195. |
[22] | 黄文锋. 无痛人流术中应用不同剂量舒芬太尼复合丙泊酚的对比研究[J]. 黑龙江医药, 2017, 30(2): 357-359. |
[23] | 林晓妹, 谭丽萍, 冯祖莲, 等. 丙泊酚配伍依托咪酯在无痛人流术中的应用效果研究[J]. 中外医疗, 2021, 40(8): 106-108. |
[24] | 陈慧, 王佳, 杨晓宇. 甲苯磺酸瑞马唑仑用于无痛人流手术的临床研究[J]. 实用妇科内分泌电子杂志, 2022, 9(26): 34-36. |
[25] | 孙圆圆, 马文辉, 李广旭. 舒芬太尼联合甲苯磺酸瑞马唑仑或丙泊酚对无痛人流患者的影响[J]. 心理月刊, 2022, 17(8): 55-57. |
[26] | 李娟, 茹六合, 马娟娟. 不同剂量瑞芬太尼在无痛人流术中应用对比分析[J]. 中国实用医药, 2016, 11(19): 222-223. |
[27] | 薛晓慧. 不同剂量瑞芬太尼用于无痛人工流产术的麻醉效果及安全性[J]. 临床医药文献电子杂志, 2019, 6(65): 20 22. |
[28] | 范雪梅, 王平, 潘楚雄, 等. 靶控输注不同浓度瑞芬太尼对无痛人流手术抑制体动丙泊酚EC50及麻醉效果的影响[J]. 临床麻醉学杂志, 2013, 29(11): 1085-1087. |
[29] | 闵卫翔, 张鹏, 王瑜, 等. 瑞芬太尼联合依托咪酯和丙泊酚在无痛人工流产麻醉中的应用[J]. 重庆医科大学学报, 2020, 45(5): 693-696. |
[30] | Jin, Y., Mao, Y., Chen, D., et al. (2022) Thalamocortical Circuits Drive Remifentanil-Induced Postoperative Hyperalgesia. Journal of Clinical Investigation, 132, e158742. |
[31] | 王明玲, 滕莉, 帅训军, 等. 丙泊酚复合不同剂量阿芬太尼用于无痛人流术的临床观察[J]. 临床麻醉学杂志, 2012, 28(3): 249-251. |
[32] | 金黎丹, 邢力, 沈耀华, 等. 瑞马唑仑与阿芬太尼联用抑制日间人流手术体动反应的半数有效剂量[J]. 浙江实用医学, 2022, 27(1): 11-13 20. |
[33] | Barrett, J.E., Shekarabi, A. and Inan, S. (2023) Oxycodone: A Current Perspective on Its Pharmacology, Abuse, and Pharmacotherapeutic Developments. Pharmacological Reviews, 75, 1062-1118. https://doi.org/10.1124/pharmrev.121.000506 |
[34] | 姚飞, 朱爱兵, 许少军, 等. 不同剂量羟考酮对无痛人流术后宫缩痛和情绪量值的影响[J]. 临床麻醉学杂志, 2019, 35(1): 12-16. |
[35] | 贾畅, 曹惠鹃, 孙莹杰, 等. 丙泊酚与环泊酚分别复合羟考酮对人流术麻醉效果的随机对照研究[J]. 实用药物与临床, 2022, 25(11): 1012-1015. |
[36] | Zhou, C., Yang, Y., Zhu, Y., et al. (2017) Effects of Dezocine on Prevention of Propofol Injection Pain: A Meta-Analysis. Journal of Pain Research, 10, 1369-1375. https://doi.org/10.2147/JPR.S128889 |
[37] | Zheng, M., Guo, Y., Shan, S., et al. (2015) Dezocine for Anesthesia and Stress Reduction in Induced Abortion. Patient Preference and Adherence, 9, 369-372. https://doi.org/10.2147/PPA.S76507 |
[38] | 赵联齐. 地佐辛联合依托咪酯麻醉在无痛人流中的应用[J]. 实用中西医结合临床, 2020, 20(1): 88-90. |
[39] | 初阳, 孙刚. 不同剂量纳布啡联合丙泊酚对宫腔镜手术患者麻醉和镇痛效果的影响[J]. 中国药房, 2017, 28(35): 4955-4959. |
[40] | Chen, L., Zhou, Y., Cai, Y., et al. (2018) The ED95 of Nalbuphine in Outpatient-Induced Abortion Compared to Equivalent Sufentanil. Basic & Clinical Pharmacology & Toxicology, 123, 202-206. https://doi.org/10.1111/bcpt.13022 |
[41] | 吕永望. 依托咪酯与丙泊酚混合复合纳布啡在无痛人流中的应用[J]. 医学理论与实践, 2022, 35(15): 2621-2623. |
[42] | 师永花, 陈良. 比较苯磺酸瑞马唑仑、依托咪酯-丙泊酚、丙泊酚在无痛舒适医疗中的镇静效果及安全性分析[J]. 齐齐哈尔医学院学报, 2022, 43(18): 1728-1731. |
[43] | 李长松, 陈鲁, 孙灿林. 盐酸氢吗啡酮滴鼻复合丙泊酚在无痛人流超前镇痛中的应用研究[J]. 泰州职业技术学院学报. 2018, 18(3): 64-67. |
[44] | 赵墨, 吴宇薇, 符永强, 等. 艾司氯胺酮联合丙泊酚用于无痛人流手术的有效性和安全性分析[J]. 中国处方药, 2022, 20(12): 98-100. |
[45] | 张宁丽, 周臣, 思永玉, 等. 艾司氯胺酮复合丙泊酚在无痛人流术中的应用[J]. 昆明医科大学学报, 2023, 44(5): 102-106. |
[46] | 王忠三, 何博, 刘一成, 等. 小剂量盐酸艾斯氯胺酮和异丙酚复合麻醉对无痛人流术的效果观察[J]. 中国现代医药杂志, 2022, 24(8): 52-54. |
[47] | Chen, J., Zou, X., Hu, B., et al. (2022) Effect of Different Doses of Esketamine Compared with Fentanyl Combined with Propofol on Hypotension in Patients Undergoing Painless Abortion Surgery: A Prospective, Randomized, Double-Blind Controlled Clinical Trial. BMC Anesthesiology, 22, Article No. 305. https://doi.org/10.1186/s12871-022-01848-6 |
[48] | Yue, L., Ma, X., Li, N., et al. (2023) Remimazolam versus Propofol in Combination with Esketamine for Surgical Abortion: A Double-Blind Randomized Controlled Trial. Clinical and Translational Science, 16, 1606-1616. https://doi.org/10.1111/cts.13572 |
[49] | 颜雪, 熊彦青, 郭小菊. 右美托咪定复合丙泊酚静脉靶控输注在无痛人流中的应用价值及对预后结局的影响[J]. 当代医学, 2022, 28(14): 115-117. |
[50] | 许程晨, 顾达民. 不同剂量右美托咪定滴鼻联合丙泊酚在无痛人流中的应用[J]. 齐齐哈尔医学院学报, 2019, 40(7): 854-856. |
[51] | 张志军, 康新国. 酮咯酸氨丁三醇对无痛人流术后子宫缩痛的疗效观察[J]. 贵州医药, 2021, 45(10): 1628-1630. |
[52] | 张德应, 漆启荣. 氟比洛芬酯注射液在无痛人流术超前镇痛中的应用研究[J]. 现代医学与健康研究电子杂志, 2022, 6(1): 44-46. |
[53] | Olausson, A., Svensson, C.J., Andréll, P., et al. (2022) Total Opioid-Free General Anaesthesia Can Improve Postoperative Outcomes after Surgery, without Evidence of Adverse Effects on Patient Safety and Pain Management: A Systematic Review and Meta-Analysis. Acta Anaesthesiologica Scandinavica, 66, 170-185. https://doi.org/10.1111/aas.13994 |