|
|
急性应激诱发大脑网络连通性的持续上升——行为激活系统的调节作用
|
Abstract:
人类不可避免地会经历各种应激事件，这些事件会引发一连串的神经内分泌反应，可能会影响大脑功能，并导致精神病理症状。先前研究表明，个体在重复应激下前额叶到边缘系统区域表现出持续的失活。然而，这一结论尚未在脑网络层面得到验证。该研究采用ScanSTRESS范式诱发应激，使用ROI-to-ROI的功能连接分析方法探讨重复应激下大脑网络间交互模式的动态变化。结果表明，突显网络充当信息中枢，突显网络内部，突显网络同视觉网络以及感觉运动网络的功能连接皆发生显著的上升。这种动态上升的幅度和应激反应的关系受到个体行为激活系统的调节。
Humans inevitably encounter various stressors that trigger a cascade of neuroendocrine responses, potentially impacting brain function and leading to psychopathological symptoms. Previous research has documented sustained deactivation from the prefrontal cortex to limbic system regions under repeated stress. However, this finding has not yet been corroborated at the level of brain networks. This study employed the ScanSTRESS paradigm to induce stress and utilized a region-of-interest (ROI)-to-ROI functional connectivity analysis to investigate the dynamic changes in inter-network interactions under repeated stress. Results indicate that the salience network acts as a central hub, with significant increases in functional connectivity both within the salience network and between the salience network, visual network, and sensorimotor network. The magnitude of this dynamic increase and its relationship to stress response are moderated by individual differences in the Behavioral Activation System.
| [1] | Carver, C.S. and White, T.L. (1994) Behavioral Inhibition, Behavioral Activation, and Affective Responses to Impending Reward and Punishment: The Bis/Bas Scales. Journal of Personality and Social Psychology, 67, 319. https://doi.org/10.1037/0022-3514.67.2.319 |
| [2] | Behzadi, Y., Restom, K., Liau, J., et al. (2007) A Component Based Noise Correction Method (Compcor) for Bold and Perfusion Based Fmri. Neuroimage, 37, 90-101. https://doi.org/10.1016/j.neuroimage.2007.04.042 |
| [3] | Yeo B, T.T., Krienen, F.M., Sepulcre, J., et al. (2011) The Organization of the Human Cerebral Cortex Estimated by Intrinsic Functional Connectivity. Journal of Neurophysiology, 106, 1125-1165. https://doi.org/10.1152/jn.00338.2011 |
| [4] | Grissom, N. and Bhatnagar, S. (2009) Habituation to Repeated Stress: Get Used to It. Neurobiology of Learning and Memory, 92, 215-224. https://doi.org/10.1016/j.nlm.2008.07.001 |
| [5] | Boyle, N.B., Lawton, C., Arkbage, K., et al. (2016) Stress Responses to Repeated Exposure to a Combined Physical and Social Evaluative Laboratory Stressor in Young Healthy Males. Psychoneuroendocrinology, 63, 119-127. https://doi.org/10.1016/j.psyneuen.2015.09.025 |
| [6] | Von Kanel, R., Kudielka, B.M., Preckel, D., et al. (2006) Delayed Response and Lack of Habituation in Plasma Interleukin-6 to Acute Mental Stress in Men. Brain Behavior and Immunity, 20, 40-48. https://doi.org/10.1016/j.bbi.2005.03.013 |
| [7] | Hermans, E.J., Henckens, M.J., Joels, M., et al. (2014) Dynamic Adaptation of Large-Scale Brain Networks in Response to Acute Stressors. Trends Neurosci, 37, 304-314. https://doi.org/10.1016/j.tins.2014.03.006 |
| [8] | Liu, Y., Hong, X., Bengson, J.J., et al. (2017) Deciding Where to Attend: Large-Scale Network Mechanisms Underlying Attention and Intention Revealed by Graph-Theoretic Analysis. Neuroimage, 157, 45-60. https://doi.org/10.1016/j.neuroimage.2017.05.048 |
| [9] | Broeders, T., Schoonheim, M., Vink, M., et al. (2021) Dorsal Attention Network Centrality Increases During Recovery From Acute Stress Exposure. Neuroimage: Clinical, 31: 102721. https://doi.org/10.1016/j.nicl.2021.102721 |
| [10] | Corbetta, M., Patel, G. and Shulman, G.L. (2008) The Reorienting System of the Human Brain: From Environment to Theory of Mind. Neuron, 58, 306-324. https://doi.org/10.1016/j.neuron.2008.04.017 |
| [11] | Qin, S.Z., Hermans, E.J., Van Marle, H.J.F., et al. (2009) Acute Psychological Stress Reduces Working Memory-Related Activity in the Dorsolateral Prefrontal Cortex. Biological Psychiatry, 66, 25-32. https://doi.org/10.1016/j.biopsych.2009.03.006 |
| [12] | Zhang, Y., Dai, Z., Hu, J., et al. (2020) Stress-Induced Changes in Modular Organizations of Human Brain Functional Networks. Neurobiology of Stress, 13, 100231. https://doi.org/10.1016/j.ynstr.2020.100231 |
| [13] | Streit, F., Haddad, L., Paul, T., Frank, J., Schafer, A., et al. (2014) A Functional Variant in the Neuropeptides Receptor 1 Gene Moderates the Influence of Urban Upbringing on Stress Processing in the Amygdala. Stress, 17, 352-361. https://doi.org/10.3109/10253890.2014.921903 |
