银屑病合并甲损害患者临床资料分析
Analysis of Clinical Data of Patients with Psoriasis Combined with Nail Damage

目的：为了解银屑病患者合并甲损害的发生率、甲损害临床特征，甲损害组与无甲损害组在人口学、疾病特征、生活质量评分之间的差异。方法：收集就诊于新疆维吾尔自治区人民医院2022年8月~2023年8月住院的80例成人银屑病住院患者的相关资料，将患者分为甲损害组与无甲损害组，分析甲银屑病相关临床特征。结果：纳入90例患者，甲损害发生率为70%，甲皱襞受累情况：甲周鳞屑最常见为51例(98.4%)，其次为甲沟炎样软组织肿胀29例(46%)，甲周红斑15例(23.8%)。甲床受累情况：最常见甲下角化过度为54例(85.7%)，其次为甲分离为47例(74.6%)、甲下油滴征45例(71.4%)、甲下裂片状出血36例(57.1%)；甲母质受累情况：点状凹陷最为常见为54例(85.7%)，其次为甲白斑26例(41.3%)、甲粗糙脆裂2例(3.2%)、甲半月红斑21例(33.3%)。其他甲损害中最为常见为甲纵脊24例(38.1%)。甲损害组与无甲损害组在体重、BMI、PASI、BSA、DLAI方面差异有统计学意义(p < 0.05)。银屑病甲损害严重程度指数与甲损害病程、甲银屑病生活质量量表评分相关；皮肤病生活质量指数与年龄、病情严重程度相关。甲损害组平均体重高于无甲损害组(t = 2.21, p = 0.03)，甲损害组平均BMI高于无甲损害组(t = 2.15, p = 0.027)。结论：银屑病合并甲损害常见，发生较多的为甲周鳞屑、甲下角化过度和点状凹陷。体重大、病情严重者更易出现甲损害。银屑病甲损害对年轻患者生活质量的影响较大，更重视银屑病对外观造成的影响。
Objective: To understand the incidence of nail damage in patients with psoriasis, the clinical characteristics of nail damage, and the differences in demographics, disease characteristics, and quality of life scores between the nail damage group and the non-nail damage group. Methods: Collecting relevant data of 80 adult inpatients with psoriasis who were hospitalized at the People’s Hospital of the Xinjiang Uygur Autonomous Region from August 2022 to August 2023. The patients were divided into nail damage groups and non-nail damage groups, and nail psoriasis disease- related clinical features was analyzed. Results: 90 patients were included, and the incidence of nail damage was 70%. Nail fold involvement: periungual scales were the most common in 51 cases (98.4%), followed by paronychia-like soft tissue swelling in 29 cases (46%). There were 15 cases (23.8%) of periungual erythema. Nail bed involvement: Subungual hyperkeratosis was the most common in 54 cases (85.7%), followed by onycholysis in 47 cases (74.6%), subungual oil drip sign in 45 cases (71.4%), and subungual splinter hemorrhage in 36 cases. cases (57.1%); nail matrix involvement: punctate depression was the most common in 54 cases (85.7%), followed by nail leukoplakia in 26 cases (41.3%), rough and brittle nails in 2 cases (3.2%), and nail half-moon erythema in 21 cases Example (33.3%). Among other nail injuries, the most common one was the longitudinal ridge of the nail in 24 cases (38.1%). There were statistically significant differences between the nail damage group and the non-nail damage group in weight, BMI, PASI, BSA, and DLAI (p < 0.05). The psoriasis nail damage severity index is related to the course of the nail damage and the nail psoriasis quality of life scale score; the skin disease life quality index is related to age and disease severity. The average weight of the nail damage