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儿童支气管肺发育不良与成年期慢性肺部疾病关系研究进展
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Abstract:
支气管肺发育不良是一种慢性肺疾病，近年来随着早产儿存活率的上升，支气管肺发育不良的发生呈现一个上升趋势。研究发现，支气管肺发育不良患儿远期可能有气体交换和气道高反应性等表现，部分支气管肺发育不良患儿成年后有肺功能受损及运动耐受下降。肺动脉高压的发生使早产儿易发生支气管肺发育不良。支气管肺发育不良与哮喘、慢性阻塞性肺疾病及肺动脉高压之间似乎有一定的相关性，但这些说法尚存在一定争议。本文对近年来支气管肺发育不良与哮喘、慢性阻塞性肺疾病及肺动脉高压之间的关系的研究进展进行综述，为支气管肺发育不良患儿远期预后的防治及研究提供思路。
Bronchopulmonary dysplasia is a chronic lung disease, with the increase of survival rate of premature infants in recent years, the incidence of bronchopulmonary dysplasia showed an upward trend. The study found that children with bronchopulmonary dysplasia may have long-term gas exchange and airway hyperresponsiveness, and some children with bronchopulmonary dysplasia have impaired lung function and decreased exercise tolerance in adulthood. The occurrence of pulmonary hypertension makes premature infants prone to bronchopulmonary dysplasia. There seems to be a certain correlation between bronchopulmonary dysplasia and asthma, chronic obstructive pulmonary disease and pulmonary hypertension, but these claims are still controversial. This article reviews the research progress on the relationship among bronchopulmonary dysplasia and asthma, chronic obstructive pulmonary disease and pulmonary hypertension in recent years, in order to provide ideas for the prevention and treatment of long-term prognosis of children with bronchopulmonary dysplasia.
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