|
|
蝶骨孤立性浆细胞瘤一例并文献复习
|
Abstract:
目的：探讨颅内孤立性骨浆细胞瘤的临床特征，诊断和治疗方案选择。方法：回顾性分析1例蝶骨孤立性浆细胞瘤患者的临床资料，并复习相关文献。结果：本例患者因“右侧眼球突出”入院，颅脑磁共振显示右侧蝶颞区见一均匀强化肿块，大小约5.7 × 4.1 × 7.0 cm。术后病理结果为浆细胞瘤。为排除多发性骨髓瘤，对患者进行相关检查，并最终诊断为蝶骨孤立性浆细胞瘤。患者术后恢复良好，并于出院后2周接受放射治疗。截至末次随访，未见肿瘤复发或进展。结论：颅内孤立性骨浆细胞瘤临床少见，确诊依赖病理组织学检查和骨髓检验，主要治疗方式为放射治疗。
Objective: This study aims to explore the clinical characteristics, diagnostic approach, and treatment strategies for intracranial solitary bone plasmacytoma. Method: A retrospective analysis of clinical data from one case of solitary plasmacytoma of the sphenoid bone was conducted, along with a review of relevant literature. Result: The patient was admitted to the hospital with a progressive proptosis of the right eyeball. Brain magnetic resonance imaging revealed a homogeneous enhancing mass in the right sphenotemporal region, measuring approximately 5.7 × 4.1 × 7.0 cm. Postoperative pathology confirmed the diagnosis of plasmacytoma. To rule out multiple myeloma, the patient underwent comprehensive examinations, ultimately leading to the diagnosis of solitary plasmacytoma of the sphenoid bone. The patient recovered well postoperatively and received radiotherapy two weeks after discharge. At the latest follow-up, no tumor recurrence or progression was observed. Conclusion: Intracranial solitary bone plasmacytoma is a rare entity, histopathological examination and bone marrow analysis are the key to the diagnosis of this disease. The optimal choice of treatment is radiotherapy.
| [1] | Alaggio, R., Amador, C., Anagnostopoulos, I., Attygalle, A.D., Araujo, I.B.D.O., Berti, E., et al. (2022) The 5th Edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms. Leukemia, 36, 1720-1748. https://doi.org/10.1038/s41375-022-01620-2 |
| [2] | Dimopoulos, M.A. and Hamilos, G. (2002) Solitary Bone Plasmacytoma and Extramedullary Plasmacytoma. Current Treatment Options in Oncology, 3, 255-259. https://doi.org/10.1007/s11864-002-0015-2 |
| [3] | Galieni, P., Cavo, M., Avvisati, G., Pulsoni, A., Falbo, R., Bonelli, M.A., et al. (1995) Solitary Plasmacytoma of Bone and Extramedullary Plasmacytoma: Two Different Entities? Annals of Oncology, 6, 687-691. https://doi.org/10.1093/oxfordjournals.annonc.a059285 |
| [4] | Caers, J., Paiva, B., Zamagni, E., et al. (2018) Diagnosis, Treatment, and Response Assessment in Solitary Plasmacytoma: Updated Recommendations from a European Expert Panel. Journal of Hematology & Oncology, 11, Article No. 10. https://doi.org/10.1186/s13045-017-0549-1 |
| [5] | Nahi, H., Genell, A., W？linder, G., Uttervall, K., Juliusson, G., Karin, F., et al. (2017) Incidence, Characteristics, and Outcome of Solitary Plasmacytoma and Plasma Cell Leukemia. Population-Based Data from the Swedish Myeloma Register. European Journal of Haematology, 99, 216-222. https://doi.org/10.1111/ejh.12907 |
| [6] | Peker, B.C., Ata？z？, Z.S. and Ozbek, Z. (2021) Solitary Plasmacytoma of the Frontal Bone. Journal of Korean Neurosurgical Society, 64, 316. https://doi.org/10.3340/jkns.2015.0105.001 |
| [7] | Gagliardi, F., Losa, M., Boari, N., Spina, A., Reni, M., Terreni, M.R., et al. (2013) Solitary Clival Plasmocytomas: Misleading Clinical and Radiological Features of a Rare Pathology with a Specific Biological Behaviour. Acta Neurochirurgica, 155, 1849-1856. https://doi.org/10.1007/s00701-013-1845-3 |
| [8] | Ustuner, Z., Basaran, M., Kiris, T., Bilgic, B., Sencer, S., Sakar, B., et al. (2004) Skull Base Plasmacytoma in a Patient with Light Chain Myeloma. Skull Base, 13, 167-172. https://doi.org/10.1055/s-2003-43327 |
| [9] | 高永涛, 陈小兵, 孙珠蕾, 等. 颅骨孤立性骨髓浆细胞瘤一例[J]. 中华神经外科杂志, 2017, 33(11): 1175-1176. https://doi.org/10.3760/cma.j.issn.1001-2346.2017.11.024 |
| [10] | 赵红军, 杨立臣, 韩云鹏, 等. 颅底骨孤立性浆细胞瘤的影像学特征分析[J]. 大连医科大学学报, 2019, 41(3): 224-228 235. |
| [11] | Ginsberg, L.E. (1992) Neoplastic Diseases Affecting the Central Skull Base: CT and MR Imaging. American Journal of Roentgenology, 159, 581-589. https://doi.org/10.2214/ajr.159.3.1503031 |
| [12] | Mansouri, H., Elouaouch, S., El Youssi, Z., Guerrouaz, M.A., Moukhlissi, M., Berhili, S., et al. (2023) Solitary Plasmacytoma of the Skull Base: A Case Report and Literature Review. Radiology Case Reports, 18, 3894-3898. https://doi.org/10.1016/j.radcr.2023.08.027 |
| [13] | Rajkumar, S.V., Dimopoulos, M.A., Palumbo, A., Blade, J., Merlini, G., Mateos, M.-V., et al. (2014) International Myeloma Working Group Updated Criteria for the Diagnosis of Multiple Myeloma. The Lancet Oncology, 15, E538-E548. https://doi.org/10.1016/S1470-2045(14)70442-5 |
| [14] | Sasaki, R., Yasuda, K., Abe, E., Uchida, N., Kawashima, M., Uno, T., et al. (2012) Multi-Institutional Analysis of Solitary Extramedullary Plasmacytoma of the Head and Neck Treated with Curative Radiotherapy. International Journal of Radiation Oncology Biology Physics, 82, 626-634. https://doi.org/10.1016/j.ijrobp.2010.11.037 |
| [15] | Ozsahin, M., Tsang, R.W., Poortmans, P., Belkacémi, Y., Bolla, M., ？ner Din？bas, F., et al. (2006) Outcomes and Patterns of Failure in Solitary Plasmacytoma: A Multicenter Rare Cancer Network Study of 258 Patients. International Journal of Radiation Oncology Biology Physics, 64, 210-217. https://doi.org/10.1016/j.ijrobp.2005.06.039 |
| [16] | Tsang, R.W., Campbell, B.A., Goda, J.S., Kelsey, C.R., Kirova, Y.M., Parikh, R.R., et al. (2018) Radiation Therapy for Solitary Plasmacytoma and Multiple Myeloma: Guidelines from the International Lymphoma Radiation Oncology Group. International Journal of Radiation Oncology Biology Physics, 101, 794-808. https://doi.org/10.1016/j.ijrobp.2018.05.009 |
| [17] | Knobel, D., Zouhair, A., Tsang, R.W., Poortmans, P., Belkacémi, Y., Bolla, M., et al. (2006) Prognostic Factors in Solitary Plasmacytoma of the Bone: A Multicenter Rare Cancer Network Study. BMC Cancer, 6, Article No. 118. https://doi.org/10.1186/1471-2407-6-118 |
| [18] | Holland, J., Trenkner, D.A., Wasserman, T.H. and Fineberg, B. (1992) Plasmacytoma. Treatment Results and Conversion to Myeloma. Cancer, 69, 1513-1517. https://doi.org/10.1002/1097-0142(19920315)69:6<1513::AID-CNCR2820690633>3.0.CO;2-X |
| [19] | Grammatico, S., Scalzulli, E. and Petrucci, M.T. (2017) Solitary Plasmacytoma. Mediterranean Journal of Hematology and Infectious Diseases, 9, E2017052. https://doi.org/10.4084/mjhid.2017.052 |
| [20] | Dingli, D., Kyle, R.A., Rajkumar, S.V., Nowakowski, G.S., Larson, D.R., Bida, J.P., et al. (2006) Immunoglobulin Free Light Chains and Solitary Plasmacytoma of Bone. Blood, 108, 1979-1983. https://doi.org/10.1182/blood-2006-04-015784 |
