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糖皮质激素诱导股骨头坏死发病机制的研究进展
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Abstract:
糖皮质激素作为治疗炎症和免疫性疾病的有效药物被广泛应用，但长期使用可能会导致许多严重的副作用，其中包括股骨头坏死。本文回顾了近年来在糖皮质激素诱导股骨头坏死发病机制方面取得的研究进展。研究发现，糖皮质激素通过增加活性氧产生和氧化应激、损伤内皮细胞和凝血功能、调节脂质代谢、影响细胞凋亡和自噬以及干扰非编码RNA的调控等途径参与股骨头坏死的发生发展。
Glucocorticoids are widely used as effective medications for the treatment of inflammatory and immune disorders, but prolonged use can lead to many serious side effects, including osteonecrosis of the femoral head. This article reviews the research progress made in recent years in the pathogenesis of glucocorticoid-induced osteonecrosis of the femoral head. It was found that glucocorticoids are involved in the development of osteonecrosis of the femoral head by increasing reactive oxygen species production and oxidative stress, damaging endothelial cells and coagulation, regulating lipid metabolism, affecting apoptosis and autophagy, as well as interfering with the regulation of non-coding RNAs.
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