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急性胰腺炎的药物治疗研究进展
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Abstract:
急性胰腺炎(AP)是一种严重的炎症过程，其范围可以从轻微的自限性疾病发展到具有显著发病率和死亡率甚至危及生命的疾病，AP是常见的急腹症之一，其发病机制非常复杂。近些年来，随着对AP的病因和发病机制的深入研究，其药物治疗有了很大进展，本文就AP药物治疗的临床研究，包括抗分泌剂、蛋白酶抑制剂、抗氧化剂、大黄类药物、常规治疗的基础上联合中药柴芩承气汤等疗法进行综述。
Acute pancreatitis (AP) is a severe inflammatory process, which can range from mild self-limiting diseases to significant morbidity and mortality and even life-threatening diseases. AP is one of the common acute abdomen diseases, and its pathogenesis is very complex. In recent years, with the in-depth study of the etiology and pathogenesis of AP, the drug treatment has made great progress, this paper reviews the clinical research of AP drug treatment, including antisecretory agents, protease inhibitors, antioxidants, rhubarb drugs, conventional treatment on the basis of combined traditional Chinese medicine qin gas decoction therapy etc.
| [1] | Mederos, M.A., Reber, H.A. and Girgis, M.D. (2021) Acute Pancreatitis: A Review. JAMA, 325, 382-390. https://doi.org/10.1001/jama.2020.20317 |
| [2] | Krishna, S.G., Kamboj, A.K., Hart, P.A., et al. (2017) The Changing Epidemiology of Acute Pancreatitis Hospitalizations: A Decade of Trends and the Impact of Chronic Pancreatitis. Pancreas, 46, 482-488. https://doi.org/10.1097/MPA.0000000000000783 |
| [3] | 周守凤, 沈曙光, 郭凯. 急性胰腺炎微循环障碍的机制及治疗进展[J]. 华南国防医学杂志, 2019, 33(6): 433-436. |
| [4] | Song, Y. and Lee, S.H. (2024) Recent Treatment Strategies for Acute Pancreatitis. Journal of Clinical Medicine, 13, Article No. 978. https://doi.org/10.3390/jcm13040978 |
| [5] | Walkowska, J., Zielinska, N., Tubbs, R.S., et al. (2022) Diagnosis and Treatment of Acute Pancreatitis. Diagnostics (Basel), 12, Article No. 1974. https://doi.org/10.3390/diagnostics12081974 |
| [6] | Severino, A., Varca, S., Airola, C., et al. (2023) Antibiotic Utilization in Acute Pancreatitis: A Narrative Review. Antibiotics (Basel), 12, Article No. 1120. https://doi.org/10.3390/antibiotics12071120 |
| [7] | Wang, G.J., Gao, C.F., Wei, D., et al. (2009) Acute Pancreatitis: Etiology and Common Pathogenesis. World Journal of Gastroenterology, 15, 1427-1430. https://doi.org/10.3748/wjg.15.1427 |
| [8] | 只茂叶. 重症急性胰腺炎的发病机制与内镜治疗研究[J]. 医学信息, 2022, 35(11): 68-71. |
| [9] | Manohar, M., Verma, A.K., Venkateshaiah, S.U., et al. (2017) Pathogenic Mechanisms of Pancreatitis. World Journal of Gastrointestinal Pharmacology and Therapeutics, 8, 10-25. https://doi.org/10.4292/wjgpt.v8.i1.10 |
| [10] | Pallagi, P., Madacsy, T., Varga, A., et al. (2020) Intracellular Ca2 Signalling in the Pathogenesis of Acute Pancreatitis: Recent Advances and Translational Perspectives. International Journal of Molecular Sciences, 21, Article No. 4005. https://doi.org/10.3390/ijms21114005 |
| [11] | Liu, J., Huang, L., Luo, M., et al. (2019) Bacterial Translocation in Acute Pancreatitis. Critical Reviews in Microbiology, 45, 539-547. https://doi.org/10.1080/1040841X.2019.1621795 |
| [12] | Easler, J.J., Mounzer, R. and Papachristou, G.I. (2012) Pharmacological Therapy for Acute Pancreatitis: Where Are We Now? Where Are We Going? Minerva Gastroenterologica e Dietologica, 58, 365-376. |
| [13] | Tang, W.F., Wang, Y.G., Zhu, L., et al. (2007) Effect of Somatostatin on Immune Inflammatory Response in Patients with Severe Acute Pancreatitis. Journal of Digestive Diseases, 8, 96-102. https://doi.org/10.1111/j.1443-9573.2007.00293.x |
| [14] | 陈卫昌, 林敏. 急性胰腺炎药物治疗进展[J]. 临床药物治疗杂志, 2010, 8(1): 28-32. |
| [15] | 刘星星. 奥曲肽联合乌司他丁治疗急性胰腺炎患者效果观察[J]. 北方药学, 2023, 20(10): 103-105, 108. |
| [16] | 盛明辉, 赵建勇. 奥曲肽联合乌司他丁对重症急性胰腺炎氧化应激及血清炎症因子的影响[J]. 贵州医药, 2019, 43(1): 25-27. |
| [17] | Chen, F., Xu, Y. and Wang, Z. (2023) Ulinastatin Combined with Somatostatin Enhances Disease Control and Modulates Serum Inflammatory Factors in Patients with Severe Pancreatitis. American Journal of Translational Research, 15, 5797-5807. |
| [18] | Yang, C., Wang, T., Chen, J., et al. (2021) Traditional Chinese Medicine Formulas Alleviate Acute Pancreatitis: Pharmacological Activities and Mechanisms. Pancreas, 50, 1348-1356. https://doi.org/10.1097/MPA.0000000000001931 |
| [19] | 王婧, 阴赪宏, 张淑文, 等. 大黄类药物治疗重症急性胰腺炎的进展[J]. 中国中西医结合急救杂志, 2005, 12(5): 318-320. |
| [20] | Lu, W., Chen, X., Ni, J., et al. (2021) Study on the Medication Rule of Traditional Chinese Medicine in the Treatment of Acute Pancreatitis Based on Machine Learning Technology. Annals of Palliative Medicine, 10, 10616-10625. https://doi.org/10.21037/apm-21-2505 |
| [21] | 高霞. 急性胰腺炎患者消化内科药物治疗临床效果观察[J]. 中国实用医药, 2017, 12(31): 118-119. |
| [22] | Du, W.D., Yuan, Z.R., Sun, J., et al. (2003) Therapeutic Efficacy of High-Dose Vitamin C on Acute Pancreatitis and Its Potential Mechanisms. World Journal of Gastroenterology, 9, 2565-2569. https://doi.org/10.3748/wjg.v9.i11.2565 |
| [23] | 靳红旗, 刘东鸣, 赵军. 大剂量维生素C治疗重症急性胰腺炎的实验研究[J]. 陕西医学杂志, 2007, 36(6): 652-653, 685. |
| [24] | Wen, Y., Xu, L., Zhang, D., et al. (2023) Effect of Early Antibiotic Treatment Strategy on Prognosis of Acute Pancreatitis. BMC Gastroenterology, 23, Article No. 431. https://doi.org/10.1186/s12876-023-03070-1 |
| [25] | Hey-Hadavi, J., Velisetty, P. and Mhatre, S. (2023) Trends and Recent Developments in Pharmacotherapy of Acute Pancreatitis. Postgraduate Medicine, 135, 334-344. https://doi.org/10.1080/00325481.2022.2136390 |
| [26] | Kambhampati, S., Park, W. and Habtezion, A. (2014) Pharmacologic Therapy for Acute Pancreatitis. World Journal of Gastroenterology, 20, 16868-16880. https://doi.org/10.3748/wjg.v20.i45.16868 |
