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探讨细胞焦亡与COPD急性加重期痰、瘀病机的关系
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Abstract:
慢性阻塞性肺疾病(COPD)是一种常见的慢性肺部疾病，属于中医“肺胀”“喘证”“咳嗽”等范畴。在COPD急性加重期机体会出现严重的炎症反应，传统医学认为其主要病理因素为痰浊与瘀血，二者相互作用是疾病发生发展的重要环节。细胞焦亡是程序性细胞死亡之一，以质膜穿孔、细胞内容物及炎症因子被释放为主要特征，其中白细胞介素1β (IL-1β)、白细胞介素18 (IL-18)等促炎症细胞因子的释放促进了痰、瘀等病理因素的形成。随着近年来对细胞焦亡的深入研究，发现其参与慢性阻塞性肺疾病患者的发生发展过程，并发挥重要作用。因此，文章从“痰、瘀”病机探讨细胞焦亡与COPD急性加重期的关系。
Chronic obstructive pulmonary disease (COPD) is a common chronic lung disease, which belongs to the category of “lung distension”, “asthma syndrome” and “cough” in traditional Chinese medicine. In the acute exacerbation of COPD, the body will have a serious inflammatory response. Traditional medicine believes that the main pathological factors are phlegm and blood stasis. The interaction between the two is an important part of the occurrence and development of the disease. Pyroptosis is one of the programmed cell death, which is characterized by plasma membrane perforation, release of cell contents and inflammatory factors. The release of pro-inflammatory cytokines such as interleukin-1β (IL-1β) and interleukin-18 (IL-18) promotes the formation of pathological factors such as phlegm and blood stasis. With the in-depth study of pyroptosis in recent years, it has been found that it is involved in the occurrence and development of patients with chronic obstructive pulmonary disease and plays an important role. Therefore, this paper discusses the relationship between pyroptosis and acute exacerbation of COPD from the pathogenesis of “phlegm and blood stasis”.
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