全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

肝硬化门静脉血栓形成的研究进展
Research Progress on Portal Vein Thrombosis in Liver Cirrhosis

DOI: 10.12677/acm.2024.1441103, PP. 894-899

Keywords: 肝硬化,门静脉血栓,机制,临床表现,研究进展
Liver Cirrhosis
, Portal Vein Thrombosis, Mechanism, Clinical Manifestations, Research Progress

Full-Text   Cite this paper   Add to My Lib

Abstract:

门静脉血栓形成是肝硬化的一种严重的并发症,可导致门脉高压和肝功能衰竭,进而引发严重后果,如食管胃底静脉曲张破裂出血、顽固性腹水和肝性脑病等,影响其预后和生活质量。过去几十年中,随着人们对门静脉血栓的逐渐重视,肝硬化门静脉血栓形成的研究也取得了一些进展,本文将从肝硬化门静脉血栓形成的发生机制、临床表现、相关因素、治疗及预后进行探讨,以期为临床预防和治疗提供科学依据。
Portal vein thrombosis is a serious complication of liver cirrhosis, which can lead to portal hypertension and liver failure, and then lead to serious consequences, such as esophageal and gastric variceal bleeding, refractory ascites and hepatic encephalopathy, which affect their prognosis and quality of life. In the past few decades, with the gradual attention to portal vein thrombosis, some progress has been made in the research of portal vein thrombosis in liver cirrhosis, and this article will discuss the pathogenesis, clinical manifestations and related factors of portal vein thrombosis in liver cirrhosis, in order to provide a scientific basis for clinical prevention and treatment.

References

[1]  Faccia, M., Santopaolo, F., Gasbarrini, A., et al. (2022) Risk Factors for Portal Vein Thrombosis or Venous Thromboembolism in a Large Cohort of Hospitalized Cirrhotic Patients. Internal and Emergency Medicine, 17, 1327-1334.
https://doi.org/10.1007/s11739-022-02928-8
[2]  Rugivarodom, M. and Charatcharoenwitthaya, P. (2020) Nontumoral Portal Vein Thrombosis: A Challenging Consequence of Liver Cirrhosis. Journal of Clinical and Translational Hepatology, 8, 432-444.
https://doi.org/10.14218/JCTH.2020.00067
[3]  Tripodi, A. and Mannucci, P.M. (2011) The Coagulopathy of Chronic Liver Disease. The New England Journal of Medicine, 365, 147-156.
https://doi.org/10.1056/NEJMra1011170
[4]  Wu, H. and Nguyen, G.C. (2010) Liver Cirrhosis Is Associated with Venous Thromboembolism among Hospitalized Patients in a Nationwide US Study. Clinical Gastroenterology and Hepatology, 8, 800-805.E1.
https://doi.org/10.1016/j.cgh.2010.05.014
[5]  Kushner, A., West, W.P., Suheb, M.Z, K., et al. (2024) Virchow Triad. StatPearls, Treasure Island.
[6]  Turon, F., Driever, E.G., Baiges, A., et al. (2021) Predicting Portal Thrombosis in Cirrhosis: A Prospective Study of Clinical, Ultrasonographic and Hemostatic Factors. Journal of Hepatology, 75, 1367-1376.
https://doi.org/10.1016/j.jhep.2021.07.020
[7]  Nery, F., Correia, S., Macedo, C., et al. (2019) Nonselective Beta-Blockers and the Risk of Portal Vein Thrombosis in Patients with Cirrhosis: Results of A Prospective Longitudinal Study. Alimentary Pharmacology & Therapeutics, 49, 582-588.
https://doi.org/10.1111/apt.15137
[8]  Dong, G., Huang, X., Zhu, Y., et al. (2021) Increased Portal Vein Diameter Is Predictive of Portal Vein Thrombosis Development in Patients with Liver Cirrhosis. Annals of Translational Medicine, 9, Article 289.
https://doi.org/10.21037/atm-20-4912
[9]  McConnell, M.J., Kostallari, E., Ibrahim, S.H. and Iwakiri, Y. (2023) The Evolving Role of Liver Sinusoidal Endothelial Cells in Liver Health and Disease. Hepatology, 78, 649-669.
https://doi.org/10.1097/HEP.0000000000000207
[10]  Takaya, H., Namisaki, T., Asada, S., et al. (2022) ADAMTS13, VWF, and Endotoxin Are Interrelated and Associated with the Severity of Liver Cirrhosis Via Hypercoagulability. Journal of Clinical Medicine, 11, Article 1835.
https://doi.org/10.3390/jcm11071835
[11]  Wang, M., Hao, H., Leeper, N.J., et al. (2018) Thrombotic Regulation from the Endothelial Cell Perspectives. Arteriosclerosis, Thrombosis, and Vascular Biology, 38, e90-e95.
https://doi.org/10.1161/ATVBAHA.118.310367
[12]  Lisman, T. and Porte, R.J. (2010) Rebalanced Hemostasis in Patients with Liver Disease: Evidence and Clinical Consequences. Blood, 116, 878-885.
https://doi.org/10.1182/blood-2010-02-261891
[13]  Chen, H., Qi, X., He, C., et al. (2013) Coagulation Imbalance May Not Contribute to the Development of Portal Vein Thrombosis in Patients with Cirrhosis. Thrombosis Research, 131, 173-177.
https://doi.org/10.1016/j.thromres.2012.11.003
[14]  Tang, W., Wang, Y., Zhao, X., et al. (2015) Procoagulant Imbalance Aggravated with Falling Liver Function Reserve, But Not Associated with the Presence of Portal Vein Thrombosis in Cirrhosis. European Journal of Gastroenterology & Hepatology, 27, 672-678.
https://doi.org/10.1097/MEG.0000000000000352
[15]  Fortea, J.I., Carrera, I.G., Puente, á., et al. (2020) Portal Thrombosis in Cirrhosis: Role of Thrombophilic Disorders. Journal of Clinical Medicine, 9, Article 2822.
https://doi.org/10.3390/jcm9092822
[16]  Tremblay, D., Naymagon, L., Troy, K., et al. (2020) The Utility of Thrombophilia Testing in Patients with Newly Diagnosed Portal Vein Thrombosis. Blood Coagulation & Fibrinolysis, 31, 213-218.
https://doi.org/10.1097/MBC.0000000000000901
[17]  Fimognari, F.L., De, Santis, A., Piccheri, C., et al. (2005) Evaluation of D-Dimer and Factor VIII in Cirrhotic Patients with Asymptomatic Portal Venous Thrombosis. The Journal of Laboratory and Clinical Medicine, 146, 238-243.
https://doi.org/10.1016/j.lab.2005.06.003
[18]  Fimognari, F.L. and Violi, F. (2008) Portal Vein Thrombosis in Liver Cirrhosis. Internal and Emergency Medicine, 3, 213-218.
https://doi.org/10.1007/s11739-008-0128-0
[19]  Amitrano, L., Anna Guardascione, M., Brancaccio, V., et al. (2004) Risk Factors and Clinical Presentation of Portal Vein Thrombosis in Patients with Liver Cirrhosis. Journal of Hepatology, 40, 736-741.
https://doi.org/10.1016/j.jhep.2004.01.001
[20]  Amitrano, L., Guardascione, M.A., Brancaccio, V., et al. (2002) Portal and Mesenteric Venous Thrombosis in Cirrhotic Patients. Gastroenterological Association, 123, 1409-1410.
https://doi.org/10.1053/gast.2002.36391
[21]  Sogaard, K.K., Astrup, L.B., Vilstrup, H. and Gronbaek, H. (2007) Portal Vein Thrombosis; Risk Factors, Clinical Presentation and Treatment. BMC Gastroenterology, 7, Article No. 34.
https://doi.org/10.1186/1471-230X-7-34
[22]  Sobhonslidsuk, A. and Reddy, K.R. (2002) Portal Vein Thrombosis: A Concise Review. The American Journal of Gastroenterology, 97, 535-541.
https://doi.org/10.1111/j.1572-0241.2002.05527.x
[23]  Condat, B. and Valla, D. (2006) Nonmalignant Portal Vein Thrombosis in Adults. Nature Clinical Practice Gastroenterology & Hepatology, 3, 505-515.
https://doi.org/10.1038/ncpgasthep0577
[24]  Romero-G?mez, M., Gutierrez-Tous, R. and Delgado-Mije, D. (2002) Anticoagulation Therapy for Recent Portal Vein Thrombosis in a Patient with Liver Cirrhosis Suffering from Variceal Rebleeding. Gastroenterological Association, 122, 2095.
https://doi.org/10.1053/gast.2002.34024
[25]  Northup, P.G., Sundaram, V., Fallon, M.B., et al. (2008) Hypercoagulation and Thrombophilia in Liver Disease. Journal of Thrombosis and Haemostasis, 6, 2-9.
https://doi.org/10.1111/j.1538-7836.2007.02772.x
[26]  Bayraktar, Y. and Harmanci, O. (2006) Etiology and Consequences of Thrombosis in Abdominal Vessels. World Journal of Gastroenterology, 12, 1165-1174.
https://doi.org/10.3748/wjg.v12.i8.1165
[27]  Stine, J.G., Wang, J., Shah, P.M., et al. (2018) Decreased Portal Vein Velocity Is Predictive of the Development of Portal Vein Thrombosis: a Matched Case-Control Study. Liver International, 38, 94-101.
https://doi.org/10.1111/liv.13500
[28]  Noronha Ferreira, C., Marinho, R.T., Cortez-Pinto, H., et al. (2019) Incidence, Predictive Factors and Clinical Significance of Development of Portal Vein Thrombosis in Cirrhosis: A Prospective Study. Liver International, 39, 1459-1467.
https://doi.org/10.1111/liv.14121
[29]  Basili, S., Carnevale, R., Nocella, C., et al. (2019) Serum Albumin Is Inversely Associated with Portal Vein Thrombosis in Cirrhosis. Hepatology Communications, 3, 504-512.
https://doi.org/10.1002/hep4.1317
[30]  Yerdel, M.A., Gunson, B., Mirza, D., et al. (2000) Portal Vein Thrombosis in Adults Undergoing Liver Transplantation: Risk Factors, Screening, Management, and Outcome. Transplantation, 69, 1873-1881.
https://doi.org/10.1097/00007890-200005150-00023
[31]  Maruyama, H., Okugawa, H., Takahashi, M., et al. (2013) De novo Portal Vein Thrombosis in Virus-Related Cirrhosis: Predictive Factors and Long-Term Outcomes. The American Journal of Gastroenterology, 108, 568-574.
https://doi.org/10.1038/ajg.2012.452
[32]  Branchford, B.R. and Carpenter, S.L. (2018) The Role of Inflammation in Venous Thromboembolism. Frontiers in Pediatrics, 6, Article 142.
https://doi.org/10.3389/fped.2018.00142
[33]  Hasan, R.A., Koh, A.Y. and Zia, A. (2020) The Gut Microbiome and Thromboembolism. Thrombosis Research, 189, 77-87.
https://doi.org/10.1016/j.thromres.2020.03.003
[34]  Moore, K.L., Andreoli, S.P., Esmon, N.L., et al. (1987) Endotoxin Enhances Tissue Factor and Suppresses Thrombomodulin Expression of Human Vascular Endothelium in Vitro. The Journal of Clinical Investigation, 79, 124-130.
https://doi.org/10.1172/JCI112772
[35]  Whitfield, C. and Trent, M.S. (2014) Biosynthesis and Export of Bacterial Lipopolysaccharides. Annual Review of Biochemistry, 83, 99-128.
https://doi.org/10.1146/annurev-biochem-060713-035600
[36]  Saghazadeh, A. and Rezaei, N. (2016) Inflammation as a Cause of Venous Thromboembolism. Critical Reviews in Oncology/Hematology, 99, 272-285.
https://doi.org/10.1016/j.critrevonc.2016.01.007
[37]  Holstein, K., Matysiak, A., Witt, L., et al. (2020) LPS-Induced Expression and Release of Monocyte Tissue Factor in Patients with Haemophilia. Annals of Hematology, 99, 1531-1542.
https://doi.org/10.1007/s00277-020-04075-6
[38]  Condat, B., Pessione, F., Helene Denninger, M., et al. (2000) Recent Portal or Mesenteric Venous Thrombosis: Increased Recognition and Frequent Recanalization on Anticoagulant Therapy. Hepatology, 32, 466-470.
https://doi.org/10.1053/jhep.2000.16597
[39]  DeLeve, L.D., Valla, D. and Garcia-Tsao, G. (2009) Vascular Disorders of the Liver. Hepatology, 49, 1729-1764.
https://doi.org/10.1002/hep.22772
[40]  Ponziani, F.R., Zocco, M.A., Campanale, C., et al. (2010) Portal Vein Thrombosis: Insight into Physiopathology, Diagnosis, and Treatment. World Journal of Gastroenterology, 16, 143-155.
https://doi.org/10.3748/wjg.v16.i2.143

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133