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心房纤维化在房颤复发中的研究新进展
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Abstract:
心房颤动(房颤)是目前临床上最常见的心律失常，随着我国老龄化问题日益加剧，房颤的患病率也呈现随年龄增长而上升的趋势。房颤发生发展的关键环节是心房解剖结构重塑和电生理机制的异常，而心房纤维化参与房颤的结构重塑和电重塑，是房颤发生和发展的病理基础。导管消融术已经成为房颤的一线治疗方法，但房颤术后存在复发现象。心房纤维化在房颤复发中有着举足轻重的作用，因此早期干预心房纤维化可能对房颤的预防、治疗及减少射频消融术后复发起到一定的作用。现对心房纤维化在房颤复发中的研究进展作一系统综述，为房颤术后复发的治疗找到更新的治疗靶点。
Atrial fibrillation (AF) is the most common arrhythmia in clinic at present. With the increasing aging problem in China, the prevalence rate of AF increases with age. The key link in the occurrence and development of atrial fibrillation is atrial anatomical remodeling and abnormal electrophysiological mechanism, and atrial fibrosis is involved in structural remodeling and electrical remodeling of atrial fibrillation, which is the pathological basis of the occurrence and development of atrial fibrillation. Catheter ablation has become the first-line treatment of atrial fibrillation, but there is recurrence after atrial fibrillation. Atrial fibrosis plays an important role in recurrence, so early intervention of atrial fibrosis may play a certain role in the prevention and treatment of atrial fibrillation and reducing recurrence after radiofrequency ablation. This paper systematically reviews the research progress of atrial fibrosis in the recurrence of atrial fibrillation, in order to find a new therapeutic target for the treatment of recurrent atrial fibrillation after operation.
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