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大肠杆菌K1与血脑屏障细胞致病机制研究进展
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Abstract:
细菌性脑膜炎是严重危害人类健康的公共健康卫生问题，尤其在儿童甚至是新生儿发病较多，且容易引发神经系统后遗症。大肠杆菌作为细菌性脑膜炎的主要致病病原体，其引起细菌性脑膜炎的发病机制仍未完全明确，病原体与宿主相互作用机制仍有许多学者研究探讨。血脑屏障作为大脑的保护屏障，其通透性改变进而引起血脑屏障结构破坏，大肠杆菌继续定植在脑膜甚至脑实质繁殖引发一系列免疫炎症反应，以此来致病。血脑屏障组成细胞种类较多，并且细胞间也会存在信号分子的交流作用，因此，大肠杆菌细菌性脑膜炎的发病机制极其复杂，理清分子生物水平的作用水平，并提出针对性的预防及治疗手段有非常深远的意义。
Bacterial meningitis is a public health problem that seriously endangers human health, especially in children and even neonates, and is prone to cause neurological sequelae. As the main pathogen of bacterial meningitis, the pathogenesis of Escherichia coli is still not fully understood, and the pathogen-host interaction mechanism is still being studied by many scholars. As a protective barrier of the brain, the permeability of the blood-brain barrier changes and then causes the destruction of the blood-brain barrier structure, and Escherichia coli continues to colonize the meninges and even the brain parenchyma to multiply, triggering a series of immune and inflammatory responses, so as to cause disease. Therefore, the pathogenesis of bacterial meningitis of E. coli is extremely complex, and it is of far-reaching significance to clarify the level of action at the molecular biological level and propose targeted prevention and treatment methods.
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