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基于FXR信号通路探究肝主疏泄的科学内涵
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Abstract:
肝主疏泄指肝具有疏通、畅通、宣达功能，与现代医学中FXR在维持机体正常运作方面相似。近年来的中西医研究也印证了藏象肝与FXR在机体生理过程中存在一定相关性。文章归纳了FXR信号通路与肝主疏泄在对脾胃运化及胆汁分泌与排泄、机体津血运行和输布、调畅情志和促进性与生殖等方面具有相似作用，并通过对消化系统、水液代谢、周围血管、脑与精神情绪、生殖代谢功能等常见病与肝主疏泄进行对比分析，发现FXR与肝主疏泄在调节全身机体机能生理功能相似，功能失常后疾病表现方面相同。研究以此为揭示肝主疏泄的分子机制提供可靠依据，并为中西医治疗肝脏代谢相关疾病提供依据，这也可能成为从分子生物学层面科学理解中医理论的新思路。
Liver governing dispersion refers to the liver has the function of dredging, unimpeded and publicity, which is similar to FXR in maintaining the normal operation of the body in modern medicine. In recent years, Chinese and Western medicine research has also confirmed that there is a certain correlation between the liver and FXR in the physiological process of the body. This paper summarizes that FXR signaling pathway and liver governing dispersion have similar effects on spleen and stomach transportation and transformation, bile secretion and excretion, body fluid and blood circulation and distribution, emotional regulation, and promotion and reproduction. Through the comparative analysis of common diseases such as digestive system, water metabolism, peripheral blood vessels, brain and mental emotion, reproductive metabolism function and liver governing dispersion, it is found that FXR and liver governing dispersion are similar in regulating the physiological function of the whole body and the disease performance after dysfunction. This study provides a reliable basis for revealing the molecular mechanism of liver governing dispersion, and provides a basis for the treatment of liver metabolism related diseases by Chinese and Western medicine. This may also become a new idea for scientific understanding of TCM theory from the perspective of molecular biology.
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